Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19
This study aimed to analyze the effect of COVID-19 vaccination on the occurrence of ARDS in hospitalized COVID-19 patients. The study population of this retrospective, single-center cohort study consisted of hospitalized COVID-19 patients with known vaccination status and chest computed tomography i...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 January 2024
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| In: |
Clinical and experimental medicine
Year: 2024, Jahrgang: 24, Heft: 1, Pages: 1-16 |
| ISSN: | 1591-9528 |
| DOI: | 10.1007/s10238-023-01293-w |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10238-023-01293-w Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s10238-023-01293-w 
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| Verfasserangaben: | Julian Madrid, Prerana Agarwal, Katharina Müller-Peltzer, Marvin Askani, Leo Benning, Mischa Selig, Philipp Diehl, Johannes Kalbhenn, Georg Trummer, Stefan Utzolino, Tobias Wengenmayer, Hans-Jörg Busch, Daiana Stolz, Siegbert Rieg, Marcus Panning, Christopher L. Schlett, Fabian Bamberg, Esther Askani |
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| 520 | |a This study aimed to analyze the effect of COVID-19 vaccination on the occurrence of ARDS in hospitalized COVID-19 patients. The study population of this retrospective, single-center cohort study consisted of hospitalized COVID-19 patients with known vaccination status and chest computed tomography imaging between July 2021 and February 2022. The impact of vaccination on ARDS in COVID-19 patients was assessed through logistic regression adjusting for demographic differences and confounding factors with statistical differences determined using confidence intervals and effect sizes. A total of 167 patients (69% male, average age 58 years, 95% CI [55; 60], 42% fully vaccinated) were included in the data analysis. Vaccinated COVID-19 patients had a reduced relative risk (RR) of developing ARDS (RR: 0.40, 95% CI [0.21; 0.62]). Consequently, non-vaccinated hospitalized patients had a 2.5-fold higher probability of developing ARDS. This risk reduction persisted after adjusting for several confounding variables (RR: 0.64, 95% CI [0.29; 0.94]) in multivariate analysis. The protective effect of COVID-19 vaccination increased with ARDS severity (RR: 0.61, 95% CI [0.37; 0.92]). Particularly, patients under 60 years old were at risk for ARDS onset and seemed to benefit from COVID-19 vaccination (RR: 0.51, 95% CI [0.20; 0.90]). COVID-19 vaccination showed to reduce the risk of ARDS occurrence in hospitalized COVID-19 patients, with a particularly strong effect in patients under 60 years old and those with more severe ARDS. | ||
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