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Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

THE APO-l/(Fas/CD95) cell surface receptor is a member of the nerve growth factor (NGF)/tumour necrosis factor (TNF) receptor superfamily and mediates apoptosis1 -4. Peripheral activated T cells (ATC) from lymphoproliferation (Ipr/lpr) mutant mice that express a reduced number of APO-1 receptors hav...

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Hauptverfasser: Dhein, Jens (VerfasserIn) , Walczak, Henning (VerfasserIn) , Bäumler, Caroline Beatrix (VerfasserIn) , Debatin, Klaus-Michael (VerfasserIn) , Krammer, Peter H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02 February 1995
In: Nature
Year: 1995, Jahrgang: 373, Heft: 6513, Pages: 438-441
ISSN:1476-4687
DOI:10.1038/373438a0
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/373438a0
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/373438a0
Volltext
Verfasserangaben:Jens Dhein, Henning Walczak, Caroline Bäumler, Klaus-Michael Debatin, Peter H. Krammer

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520 |a THE APO-l/(Fas/CD95) cell surface receptor is a member of the nerve growth factor (NGF)/tumour necrosis factor (TNF) receptor superfamily and mediates apoptosis1 -4. Peripheral activated T cells (ATC) from lymphoproliferation (Ipr/lpr) mutant mice that express a reduced number of APO-1 receptors have a defect in T-cell receptor (TCR)-induced apoptosis5,6. This suggests that TCR-induced apoptosis involves APO-1. We tested this hypothesis in various human T cells: (1) malignant Jurkat cells, (2) an allo-reactive T-cell clone (S13), and (3) peripheral ATC. TCR triggering through immobilized anti-CD3 antibodies or Staphylococcus enterotoxin B (SEB) superantigen induced expression of the APO-1 ligand and apoptosis in these cells. Anti-CD3-induced apoptosis of Jurkat cells was demonstrated even in single-cell cultures. In all cases apoptosis was substantially inhibited by blocking anti-APO-1 antibody fragments and soluble APO-1 receptor decoys. The APO-1 ligand was found in the supernatant of activated Jurkat cells as a soluble cytokine. We propose that TCR-induced apoptosis in ATC can occur through an APO-1 ligand-mediated autocrine suicide. These results provide a mechanism for suppression of the immune response and for peripheral tolerance by T-cell deletion. 
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