Patterns, predictors and prognostic relevance of high-grade hematotoxicity after temozolomide or temozolomide-lomustine in the CeTeG/NOA-09 trial
In the randomized phase III trial CeTeG/NOA-09, temozolomide (TMZ)/lomustine (CCNU) combination therapy was superior to TMZ in newly diagnosed MGMT methylated glioblastoma, albeit reporting more frequent hematotoxicity. Here, we analyze high grade hematotoxicity and its prognostic relevance in the t...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2023
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| In: |
Journal of neuro-oncology
Year: 2023, Jahrgang: 161, Heft: 1, Pages: 147-153 |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-022-04203-4 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-022-04203-4 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11060-022-04203-4 |
| Verfasserangaben: | J. Weller, N. Schäfer, C. Schaub, T. Tzaridis, T. Zeyen, M. Schneider, A.L. Potthoff, F.A. Giordano, J.P. Steinbach, P.S. Zeiner, T. Kowalski, M. Sabel, P. Hau, D. Krex, O. Grauer, R. Goldbrunner, O. Schnell, G. Tabatabai, F. Ringel, F. Schmidt-Graf, S. Brehmer, J.C. Tonn, L. Bullinger, P. Vajkoczy, M. Glas, H. Vatter, U. Herrlinger, C. Seidel |
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| 520 | |a In the randomized phase III trial CeTeG/NOA-09, temozolomide (TMZ)/lomustine (CCNU) combination therapy was superior to TMZ in newly diagnosed MGMT methylated glioblastoma, albeit reporting more frequent hematotoxicity. Here, we analyze high grade hematotoxicity and its prognostic relevance in the trial population. | ||
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