Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification
Background: Clinical evidence suggests an association between phosphate concentrations in aqueous humor and the risk of intraocular lens (IOL) calcification. To test this hypothesis the influence of different phosphate concentrations on IOL calcification was evaluated in an in vitro electrophoresis...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 August 2024
|
| In: |
BMC ophthalmology
Year: 2024, Jahrgang: 24, Pages: 1-12 |
| ISSN: | 1471-2415 |
| DOI: | 10.1186/s12886-024-03553-z |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12886-024-03553-z
|
| Verfasserangaben: | Rebecca Buhl, Timur Mert Yildirim, Sonja Katrin Schickhardt, Leoni Britz, Ingo Lieberwirth, Gerd Uwe Auffarth and Ramin Khoramnia |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1903056055 | ||
| 003 | DE-627 | ||
| 005 | 20241205173415.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240920s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12886-024-03553-z |2 doi | |
| 035 | |a (DE-627)1903056055 | ||
| 035 | |a (DE-599)KXP1903056055 | ||
| 035 | |a (OCoLC)1475312667 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Buhl, Rebecca |d 1997- |e VerfasserIn |0 (DE-588)1342552644 |0 (DE-627)1903056500 |4 aut | |
| 245 | 1 | 0 | |a Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification |c Rebecca Buhl, Timur Mert Yildirim, Sonja Katrin Schickhardt, Leoni Britz, Ingo Lieberwirth, Gerd Uwe Auffarth and Ramin Khoramnia |
| 264 | 1 | |c 23 August 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.09.2024 | ||
| 520 | |a Background: Clinical evidence suggests an association between phosphate concentrations in aqueous humor and the risk of intraocular lens (IOL) calcification. To test this hypothesis the influence of different phosphate concentrations on IOL calcification was evaluated in an in vitro electrophoresis model. Methods: 20 IOLs of two hydrophilic IOL models (CT Spheris 204, Zeiss; Lentis L-313, Oculentis) and one hydrophobic control IOL model (Clareon CNA0T0, Alcon) were exposed to physiologic and elevated phosphate concentrations, similar to diabetic aqueous humor. IOL calcification was analyzed by alizarin red staining, von Kossa staining, scanning electron microscopy, energy dispersive x-ray spectroscopy and transmission electron microscopy with electron diffraction. Results: Higher phosphate concentrations were associated with IOL calcification. Analyses of IOL surfaces and cross-sections documented calcification in no CT Spheris and 4 Lentis IOLs following exposure to 10 mM Na2HPO4, compared with 7 and 11 positive analyses following exposure to 14 mM Na2HPO4, respectively. Furthermore, a clear association between IOL calcification and the duration of electrophoresis was demonstrated, confirming increased phosphate concentrations and duration of exposure as risk factors of IOL calcification. Conclusions: Findings suggest that higher phosphate concentrations in aqueous humor, as seen in diabetic patients, contribute to an increased IOL calcification risk, potentially explaining clinical observations showing an increased risk of IOL calcification in patients with diabetes. | ||
| 650 | 4 | |a Aqueous humor | |
| 650 | 4 | |a Diabetes | |
| 650 | 4 | |a IOL Calcification | |
| 650 | 4 | |a Phosphate concentration | |
| 650 | 4 | |a Proliferative diabetic retinopathy | |
| 700 | 1 | |a Yildirim, Timur Mert |d 1990- |e VerfasserIn |0 (DE-588)112972557X |0 (DE-627)88437422X |0 (DE-576)486529894 |4 aut | |
| 700 | 1 | |a Schickhardt, Sonja |e VerfasserIn |0 (DE-588)121213723X |0 (DE-627)1700745808 |4 aut | |
| 700 | 1 | |a Britz, Leoni |d 1995- |e VerfasserIn |0 (DE-588)1260484815 |0 (DE-627)1807312550 |4 aut | |
| 700 | 1 | |a Lieberwirth, Ingo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Auffarth, Gerd U. |d 1964- |e VerfasserIn |0 (DE-588)123385261 |0 (DE-627)577130420 |0 (DE-576)293687277 |4 aut | |
| 700 | 1 | |a Khoramnia, Ramin |d 1980- |e VerfasserIn |0 (DE-588)132573954 |0 (DE-627)523957173 |0 (DE-576)299234355 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BMC ophthalmology |d London : BioMed Central, 2001 |g 24(2024), Artikel-ID 363, Seite 1-12 |h Online-Ressource |w (DE-627)331018772 |w (DE-600)2050436-6 |w (DE-576)107014939 |x 1471-2415 |7 nnas |a Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification |
| 773 | 1 | 8 | |g volume:24 |g year:2024 |g elocationid:363 |g pages:1-12 |g extent:12 |a Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s12886-024-03553-z |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240920 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 132573954 |a Khoramnia, Ramin |m 132573954:Khoramnia, Ramin |d 910000 |d 910900 |d 50000 |e 910000PK132573954 |e 910900PK132573954 |e 50000PK132573954 |k 0/910000/ |k 1/910000/910900/ |k 0/50000/ |p 7 |y j | ||
| 998 | |g 123385261 |a Auffarth, Gerd U. |m 123385261:Auffarth, Gerd U. |d 910000 |d 910900 |e 910000PA123385261 |e 910900PA123385261 |k 0/910000/ |k 1/910000/910900/ |p 6 | ||
| 998 | |g 1260484815 |a Britz, Leoni |m 1260484815:Britz, Leoni |d 910000 |d 910900 |e 910000PB1260484815 |e 910900PB1260484815 |k 0/910000/ |k 1/910000/910900/ |p 4 | ||
| 998 | |g 121213723X |a Schickhardt, Sonja |m 121213723X:Schickhardt, Sonja |d 910000 |d 910900 |e 910000PS121213723X |e 910900PS121213723X |k 0/910000/ |k 1/910000/910900/ |p 3 | ||
| 998 | |g 112972557X |a Yildirim, Timur Mert |m 112972557X:Yildirim, Timur Mert |d 910000 |d 910900 |e 910000PY112972557X |e 910900PY112972557X |k 0/910000/ |k 1/910000/910900/ |p 2 | ||
| 998 | |g 1342552644 |a Buhl, Rebecca |m 1342552644:Buhl, Rebecca |d 910000 |d 910900 |e 910000PB1342552644 |e 910900PB1342552644 |k 0/910000/ |k 1/910000/910900/ |p 1 |x j | ||
| 999 | |a KXP-PPN1903056055 |e 4581917913 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"23 August 2024"}],"id":{"eki":["1903056055"],"doi":["10.1186/s12886-024-03553-z"]},"person":[{"family":"Buhl","role":"aut","display":"Buhl, Rebecca","given":"Rebecca"},{"given":"Timur Mert","display":"Yildirim, Timur Mert","role":"aut","family":"Yildirim"},{"given":"Sonja","family":"Schickhardt","role":"aut","display":"Schickhardt, Sonja"},{"role":"aut","display":"Britz, Leoni","family":"Britz","given":"Leoni"},{"family":"Lieberwirth","display":"Lieberwirth, Ingo","role":"aut","given":"Ingo"},{"display":"Auffarth, Gerd U.","role":"aut","family":"Auffarth","given":"Gerd U."},{"family":"Khoramnia","role":"aut","display":"Khoramnia, Ramin","given":"Ramin"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Rebecca Buhl, Timur Mert Yildirim, Sonja Katrin Schickhardt, Leoni Britz, Ingo Lieberwirth, Gerd Uwe Auffarth and Ramin Khoramnia"]},"title":[{"title":"Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification","title_sort":"Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification"}],"relHost":[{"language":["eng"],"pubHistory":["1.2001 -"],"origin":[{"dateIssuedDisp":"2001-","publisher":"BioMed Central","dateIssuedKey":"2001","publisherPlace":"London"}],"part":{"pages":"1-12","volume":"24","extent":"12","text":"24(2024), Artikel-ID 363, Seite 1-12","year":"2024"},"id":{"issn":["1471-2415"],"eki":["331018772"],"zdb":["2050436-6"]},"disp":"Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcificationBMC ophthalmology","title":[{"title_sort":"BMC ophthalmology","title":"BMC ophthalmology"}],"recId":"331018772","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 28.07.2021"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"recId":"1903056055","physDesc":[{"noteIll":"Illustrationen","extent":"12 S."}],"note":["Gesehen am 20.09.2024"],"language":["eng"]} | ||
| SRT | |a BUHLREBECCHIGHERPHOS2320 | ||