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Proteomic dynamics of breast cancer cell lines identifies potential therapeutic protein targets

Treatment and relevant targets for breast cancer (BC) remain limited, especially for triple-negative BC (TNBC). We identified 6091 proteins of 76 human BC cell lines using data-independent acquisition (DIA). Integrating our proteomic findings with prior multi-omics datasets, we found that including...

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Main Authors: Sun, Rui (Author) , Ge, Weigang (Author) , Zhu, Yi (Author) , Sayad, Azin (Author) , Luna, Augustin (Author) , Lyu, Mengge (Author) , Liang, Shuang (Author) , Tobalina, Luis (Author) , Rajapakse, Vinodh N. (Author) , Yu, Chenhuan (Author) , Zhang, Huanhuan (Author) , Fang, Jie (Author) , Wu, Fang (Author) , Xie, Hui (Author) , Sáez Rodríguez, Julio (Author) , Ying, Huazhong (Author) , Reinhold, William C. (Author) , Sander, Chris (Author) , Pommier, Yves (Author) , Neel, Benjamin G. (Author) , Aebersold, Ruedi (Author) , Guo, Tiannan (Author)
Format: Article (Journal)
Language:English
Published: 19 June 2023
In: Molecular & cellular proteomics
Year: 2023, Volume: 22, Issue: 8, Pages: 1-15
ISSN:1535-9484
DOI:10.1016/j.mcpro.2023.100602
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.mcpro.2023.100602
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1535947623001135
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Author Notes:Rui Sun, Weigang Ge, Yi Zhu, Azin Sayad, Augustin Luna, Mengge Lyu, Shuang Liang, Luis Tobalina, Vinodh N. Rajapakse, Chenhuan Yu, Huanhuan Zhang, Jie Fang, Fang Wu, Hui Xie, Julio Saez-Rodriguez, Huazhong Ying, William C. Reinhold, Chris Sander, Yves Pommier, Benjamin G. Neel, Ruedi Aebersold, Tiannan Guo
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Summary:Treatment and relevant targets for breast cancer (BC) remain limited, especially for triple-negative BC (TNBC). We identified 6091 proteins of 76 human BC cell lines using data-independent acquisition (DIA). Integrating our proteomic findings with prior multi-omics datasets, we found that including proteomics data improved drug sensitivity predictions and provided insights into the mechanisms of action. We subsequently profiled the proteomic changes in nine cell lines (five TNBC and four non-TNBC) treated with EGFR/AKT/mTOR inhibitors. In TNBC, metabolism pathways were dysregulated after EGFR/mTOR inhibitor treatment, while RNA modification and cell cycle pathways were affected by AKT inhibitor. This systematic multi-omics and in-depth analysis of the proteome of BC cells can help prioritize potential therapeutic targets and provide insights into adaptive resistance in TNBC.
Item Description:Gesehen am 23.09.2024
Physical Description:Online Resource
ISSN:1535-9484
DOI:10.1016/j.mcpro.2023.100602

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