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Novel anti-inflammatory effects of canagliflozin involving Hexokinase II in lipopolysaccharide-stimulated human coronary artery endothelial cells

Vascular inflammation and disturbed metabolism are observed in heart failure and type 2 diabetes mellitus. Glycolytic enzyme hexokinase II (HKII) is upregulated by inflammation. We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammat...

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Main Authors: Uthman, Laween (Author) , Kuschma, Marius Christian (Author) , Römer, Gregor (Author) , Boomsma, Marleen (Author) , Keßler, Jens (Author) , Hermanides, Jeroen (Author) , Hollmann, Markus W. (Author) , Preckel, Benedikt (Author) , Zuurbier, Coert J. (Author) , Weber, Nina C. (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Cardiovascular drugs and therapy
Year: 2021, Volume: 35, Issue: 6, Pages: 1083-1094
ISSN:1573-7241
DOI:10.1007/s10557-020-07083-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10557-020-07083-w
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s10557-020-07083-w
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Author Notes:Laween Uthman, Marius Kuschma, Gregor Römer, Marleen Boomsma, Jens Kessler, Jeroen Hermanides, Markus W. Hollmann, Benedikt Preckel, Coert J. Zuurbier, Nina C. Weber

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520 |a Vascular inflammation and disturbed metabolism are observed in heart failure and type 2 diabetes mellitus. Glycolytic enzyme hexokinase II (HKII) is upregulated by inflammation. We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammation via HKII in endothelial cells, and that HKII-dependent inflammation is determined by ERK1/2, NF-κB. and/or AMPK activity in lipopolysaccharide (LPS)-stimulated human coronary artery endothelial cells (HCAECs). 
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