Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children
Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 September 1996
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| In: |
Blood
Year: 1996, Jahrgang: 88, Heft: 5, Pages: 1741-1746 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood.V88.5.1741.1741 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.V88.5.1741.1741 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120635285 
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| Verfasserangaben: | Caroline B. Bäumler, Thomas Bonier, Ingrid Herr, Axel Benner, Peter H. Krammer, Klaus-Michael Debatin |
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| 245 | 1 | 0 | |a Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children |c Caroline B. Bäumler, Thomas Bonier, Ingrid Herr, Axel Benner, Peter H. Krammer, Klaus-Michael Debatin |
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| 520 | |a Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-infected children. In this report we provide further evidence for a deregulated CD95 system in AIDS. CD95 expression in HIV-1+ children is not restricted to previously activated CD45RO+ T cells but is also increased on freshly isolated naive CD45RA+ T cells. In addition, specific CD95-mediated apoptosis is enhanced in both CD4+ and CD8+ T cells. Furthermore, levels of CD95 ligand mRNA are profoundly increased. Specific T-cell receptor/CD3-triggered apoptosis in HIV-1+ children is more enhanced in CD8+ than in CD4+ T cells. Accelerated activation induced cell death of T cells could partially be inhibited by blocking anti-CD95 antibody fragments. These data suggest an involvement of the CD95 receptor/ligand system in T-cell depletion and apoptosis in AIDS and may open new avenues of rational intervention strategies. | ||
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