Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity : a potential diagnostic pitfall in patients with MOG-EM/MOGAD
Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD) is the most important differential diagnosis of both multiple sclerosis and neuromyelitis optica spectrum disorders. A recent proposal for new diagnostic criteria fo...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
13 April 2024
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| In: |
Journal of neurology
Year: 2024, Jahrgang: 271, Heft: 7, Pages: 4660-4671 |
| ISSN: | 1432-1459 |
| DOI: | 10.1007/s00415-024-12285-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00415-024-12285-5
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| Verfasserangaben: | S. Jarius, M. Ringelstein, K. Schanda, K. Ruprecht, M. Korporal-Kuhnke, A. Viehöver, M.W. Hümmert, P. Schindler, V. Endmayr, M. Gastaldi, C. Trebst, D. Franciotta, O. Aktas, R. Höftberger, J. Haas, L. Komorowski, F. Paul, M. Reindl, B. Wildemann |
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| 245 | 1 | 0 | |a Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing |b exclusive or predominant MOG-IgG3 seropositivity : a potential diagnostic pitfall in patients with MOG-EM/MOGAD |c S. Jarius, M. Ringelstein, K. Schanda, K. Ruprecht, M. Korporal-Kuhnke, A. Viehöver, M.W. Hümmert, P. Schindler, V. Endmayr, M. Gastaldi, C. Trebst, D. Franciotta, O. Aktas, R. Höftberger, J. Haas, L. Komorowski, F. Paul, M. Reindl, B. Wildemann |
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| 520 | |a Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD) is the most important differential diagnosis of both multiple sclerosis and neuromyelitis optica spectrum disorders. A recent proposal for new diagnostic criteria for MOG-EM/MOGAD explicitly recommends the use of immunoglobulin G subclass 1 (IgG1)- or IgG crystallizable fragment (Fc) region-specific assays and allows the use of heavy-and-light-chain-(H+L) specific assays for detecting MOG-IgG. By contrast, the utility of MOG-IgG3-specific testing has not been systematically evaluated. | ||
| 650 | 4 | |a Antibodies | |
| 650 | 4 | |a Aquaporin-4 (AQP4) | |
| 650 | 4 | |a Assays | |
| 650 | 4 | |a Autoantibody | |
| 650 | 4 | |a Detection antibodies | |
| 650 | 4 | |a IgG subclasses | |
| 650 | 4 | |a Immunoglobulin G (IgG) | |
| 650 | 4 | |a MOG antibody-associated disease (MOGAD) | |
| 650 | 4 | |a MOG antibody-associated encephalomyelitis (MOG-EM) | |
| 650 | 4 | |a MOG-IgG1 | |
| 650 | 4 | |a MOG-IgG3 | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Myelin oligodendrocyte glycoprotein (MOG) | |
| 650 | 4 | |a Myelitis | |
| 650 | 4 | |a Neuromyelitis optica spectrum disorders (NMOSD) | |
| 650 | 4 | |a Optic neuritis | |
| 650 | 4 | |a Rozanolixizumab | |
| 650 | 4 | |a Sensitivity | |
| 650 | 4 | |a Seroconversion | |
| 650 | 4 | |a Serology | |
| 650 | 4 | |a Seronegative | |
| 650 | 4 | |a Seronegativity | |
| 650 | 4 | |a Seroreversion | |
| 650 | 4 | |a Tests | |
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| 700 | 1 | |a Aktas, O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Höftberger, R. |e VerfasserIn |4 aut | |
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