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Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity : a potential diagnostic pitfall in patients with MOG-EM/MOGAD

Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD) is the most important differential diagnosis of both multiple sclerosis and neuromyelitis optica spectrum disorders. A recent proposal for new diagnostic criteria fo...

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Main Authors: Jarius, Sven (Author) , Ringelstein, M. (Author) , Schanda, K. (Author) , Ruprecht, K. (Author) , Korporal-Kuhnke, Mirjam (Author) , Viehöver, Andrea Maria (Author) , Hümmert, M. W. (Author) , Schindler, P. (Author) , Endmayr, V. (Author) , Gastaldi, M. (Author) , Trebst, C. (Author) , Franciotta, D. (Author) , Aktas, O. (Author) , Höftberger, R. (Author) , Haas, Jürgen (Author) , Komorowski, L. (Author) , Paul, F. (Author) , Reindl, M. (Author) , Wildemann, Brigitte (Author)
Format: Article (Journal) Editorial
Language:English
Published: 13 April 2024
In: Journal of neurology
Year: 2024, Volume: 271, Issue: 7, Pages: 4660-4671
ISSN:1432-1459
DOI:10.1007/s00415-024-12285-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00415-024-12285-5
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Author Notes:S. Jarius, M. Ringelstein, K. Schanda, K. Ruprecht, M. Korporal-Kuhnke, A. Viehöver, M.W. Hümmert, P. Schindler, V. Endmayr, M. Gastaldi, C. Trebst, D. Franciotta, O. Aktas, R. Höftberger, J. Haas, L. Komorowski, F. Paul, M. Reindl, B. Wildemann
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Summary:Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD) is the most important differential diagnosis of both multiple sclerosis and neuromyelitis optica spectrum disorders. A recent proposal for new diagnostic criteria for MOG-EM/MOGAD explicitly recommends the use of immunoglobulin G subclass 1 (IgG1)- or IgG crystallizable fragment (Fc) region-specific assays and allows the use of heavy-and-light-chain-(H+L) specific assays for detecting MOG-IgG. By contrast, the utility of MOG-IgG3-specific testing has not been systematically evaluated.
Item Description:Gesehen am 27.09.2024
Physical Description:Online Resource
ISSN:1432-1459
DOI:10.1007/s00415-024-12285-5

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