Five-fraction stereotactic radiotherapy for brain metastases: a retrospective analysis
Purpose: To determine the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM), either as a definitive or adjuvant treatment. Methods: We assessed clinical data of patients receiving five fractions of 7 Gy each (cumulative physical dose of 35 Gy) to...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 January 2023
|
| In: |
Current oncology
Year: 2023, Volume: 30, Issue: 2, Pages: 1300-1313 |
| ISSN: | 1718-7729 |
| DOI: | 10.3390/curroncol30020101 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/curroncol30020101 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1718-7729/30/2/101 
|
| Author Notes: | Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Röhner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano and Leonard Christopher Schmeel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1903723000 | ||
| 003 | DE-627 | ||
| 005 | 20241205174637.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240930s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/curroncol30020101 |2 doi | |
| 035 | |a (DE-627)1903723000 | ||
| 035 | |a (DE-599)KXP1903723000 | ||
| 035 | |a (OCoLC)1475313544 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Layer, Julian |e VerfasserIn |0 (DE-588)1188256440 |0 (DE-627)1667212931 |4 aut | |
| 245 | 1 | 0 | |a Five-fraction stereotactic radiotherapy for brain metastases |b a retrospective analysis |c Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Röhner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano and Leonard Christopher Schmeel |
| 264 | 1 | |c 17 January 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.09.2024 | ||
| 520 | |a Purpose: To determine the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM), either as a definitive or adjuvant treatment. Methods: We assessed clinical data of patients receiving five fractions of 7 Gy each (cumulative physical dose of 35 Gy) to BM or surgical cavities. The primary endpoints were toxicity and radiation necrosis (RN) rates. Secondary endpoints were 1-year cumulative local control rate (LCR) and estimated overall survival (OS). Results: A total of 36 eligible patients receiving FSRT to a total of 49 targets were identified and included. The median follow up was 9 (1.1-56.2) months. The median age was 64.5 (34-92) years, the median ECOG score was 1, and the median Diagnostic-Specific Graded Prognostic Assessment (DS-GPA) score was 2. Treatment was well tolerated and there were no grade 3 adverse events or higher. The overall RN rate was 14.3% and the median time to RN was 12.9 (1.8-23.8) months. RN occurrence was associated with immunotherapy, young age (≤45 years), and large PTV. The cumulative 1-year local control rate was 83.1% and the estimated median local progression free-survival was 18.8 months. The estimated median overall survival was 11 (1.1-56.2) months and significantly superior in those patients presenting with RN. Conclusions: FSRT with 5 × 7 Gy represents a feasible, safe, and efficient fast track approach of intensified FSRT with acceptable LC and comparable RN rates for both the adjuvant and definitive RT settings. | ||
| 650 | 4 | |a brain metastases | |
| 650 | 4 | |a FSRT | |
| 650 | 4 | |a hypofractionation | |
| 650 | 4 | |a radiation necrosis | |
| 650 | 4 | |a stereotactic radiotherapy | |
| 650 | 4 | |a toxicity | |
| 700 | 1 | |a Layer, Katharina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sarria, Gustavo R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Röhner, Fred |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dejonckheere, Cas S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Friker, Lea L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zeyen, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koch, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scafa, Davide |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leitzen, Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Köksal, Mümtaz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmeel, Frederic Carsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schäfer, Niklas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Landsberg, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hölzel, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herrlinger, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giordano, Frank Anton |d 1980- |e VerfasserIn |0 (DE-588)136378455 |0 (DE-627)694333093 |0 (DE-576)300990529 |4 aut | |
| 700 | 1 | |a Schmeel, Leonard Christopher |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current oncology |d Toronto, Ontario : Multimed, 2005 |g 30(2023), 2, Seite 1300-1313 |h Online-Ressource |w (DE-627)524623112 |w (DE-600)2270777-3 |w (DE-576)347278280 |x 1718-7729 |7 nnas |a Five-fraction stereotactic radiotherapy for brain metastases a retrospective analysis |
| 773 | 1 | 8 | |g volume:30 |g year:2023 |g number:2 |g pages:1300-1313 |g extent:14 |a Five-fraction stereotactic radiotherapy for brain metastases a retrospective analysis |
| 856 | 4 | 0 | |u https://doi.org/10.3390/curroncol30020101 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1718-7729/30/2/101 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240930 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 136378455 |a Giordano, Frank Anton |m 136378455:Giordano, Frank Anton |d 60000 |d 63000 |e 60000PG136378455 |e 63000PG136378455 |k 0/60000/ |k 1/60000/63000/ |p 18 | ||
| 999 | |a KXP-PPN1903723000 |e 4584622779 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 30.09.2024"],"id":{"doi":["10.3390/curroncol30020101"],"eki":["1903723000"]},"relHost":[{"language":["eng"],"title":[{"title_sort":"Current oncology","title":"Current oncology"}],"disp":"Five-fraction stereotactic radiotherapy for brain metastases a retrospective analysisCurrent oncology","id":{"eki":["524623112"],"zdb":["2270777-3"],"issn":["1718-7729"]},"recId":"524623112","note":["Gesehen am 21.11.2025","Volltext auch als Teil einer Datenbank verfügbar"],"origin":[{"publisher":"Multimed","dateIssuedKey":"2005","dateIssuedDisp":"2005-","publisherPlace":"Toronto, Ontario"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"30(2023), 2, Seite 1300-1313","year":"2023","issue":"2","extent":"14","pages":"1300-1313","volume":"30"},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Nachgewiesen 12.2005 -"]}],"person":[{"roleDisplay":"VerfasserIn","role":"aut","display":"Layer, Julian","family":"Layer","given":"Julian"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Layer","display":"Layer, Katharina","given":"Katharina"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Sarria, Gustavo R.","family":"Sarria","given":"Gustavo R."},{"given":"Fred","display":"Röhner, Fred","family":"Röhner","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Cas S.","roleDisplay":"VerfasserIn","role":"aut","family":"Dejonckheere","display":"Dejonckheere, Cas S."},{"role":"aut","roleDisplay":"VerfasserIn","family":"Friker","display":"Friker, Lea L.","given":"Lea L."},{"roleDisplay":"VerfasserIn","role":"aut","display":"Zeyen, Thomas","family":"Zeyen","given":"Thomas"},{"given":"David","role":"aut","roleDisplay":"VerfasserIn","family":"Koch","display":"Koch, David"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Scafa","display":"Scafa, Davide","given":"Davide"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Leitzen, Christina","family":"Leitzen","given":"Christina"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Köksal, Mümtaz","family":"Köksal","given":"Mümtaz"},{"given":"Frederic Carsten","display":"Schmeel, Frederic Carsten","family":"Schmeel","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schäfer, Niklas","family":"Schäfer","given":"Niklas"},{"given":"Jennifer","display":"Landsberg, Jennifer","family":"Landsberg","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Michael","roleDisplay":"VerfasserIn","role":"aut","display":"Hölzel, Michael","family":"Hölzel"},{"display":"Herrlinger, Ulrich","family":"Herrlinger","role":"aut","roleDisplay":"VerfasserIn","given":"Ulrich"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Schneider","display":"Schneider, Matthias","given":"Matthias"},{"given":"Frank Anton","display":"Giordano, Frank Anton","family":"Giordano","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Leonard Christopher","display":"Schmeel, Leonard Christopher","family":"Schmeel","role":"aut","roleDisplay":"VerfasserIn"}],"recId":"1903723000","language":["eng"],"name":{"displayForm":["Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Röhner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano and Leonard Christopher Schmeel"]},"title":[{"subtitle":"a retrospective analysis","title":"Five-fraction stereotactic radiotherapy for brain metastases","title_sort":"Five-fraction stereotactic radiotherapy for brain metastases"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"14 S.","noteIll":"Illustrationen"}],"origin":[{"dateIssuedDisp":"17 January 2023","dateIssuedKey":"2023"}]} | ||
| SRT | |a LAYERJULIAFIVEFRACTI1720 | ||