Analysis of inflammation-related genes in patients with stanford type A aortic dissection
Background: Aortic dissection (AD) is a life-threatening cardiovascular disease. Pathophysiologically, it has been shown that aortic wall inflammation promotes the occurrence and development of aortic dissection. Thus, the aim of the current research was to determine the inflammation-related biomark...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 June 2023
|
| In: |
Journal of Personalized Medicine
Year: 2023, Jahrgang: 13, Heft: 6, Pages: 1-17 |
| ISSN: | 2075-4426 |
| DOI: | 10.3390/jpm13060990 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jpm13060990 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4426/13/6/990 
|
| Verfasserangaben: | Lin Li, Ziwei Zeng, Vugar Yagublu, Nuh Rahbari, Christoph Reißfelder and Michael Keese |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1903730643 | ||
| 003 | DE-627 | ||
| 005 | 20241205174712.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240930s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/jpm13060990 |2 doi | |
| 035 | |a (DE-627)1903730643 | ||
| 035 | |a (DE-599)KXP1903730643 | ||
| 035 | |a (OCoLC)1475313520 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Li, Lin |d 1993- |e VerfasserIn |0 (DE-588)1296626865 |0 (DE-627)1853082333 |4 aut | |
| 245 | 1 | 0 | |a Analysis of inflammation-related genes in patients with stanford type A aortic dissection |c Lin Li, Ziwei Zeng, Vugar Yagublu, Nuh Rahbari, Christoph Reißfelder and Michael Keese |
| 264 | 1 | |c 13 June 2023 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.09.2024 | ||
| 520 | |a Background: Aortic dissection (AD) is a life-threatening cardiovascular disease. Pathophysiologically, it has been shown that aortic wall inflammation promotes the occurrence and development of aortic dissection. Thus, the aim of the current research was to determine the inflammation-related biomarkers in AD. Methods: In this study, we conducted differentially expressed genes (DEGs) analysis using the GSE153434 dataset containing 10 type A aortic dissection (TAAD) and 10 normal samples downloaded from the Gene Expression Omnibus (GEO) database. The intersection of DEGs and inflammation-related genes was identified as differential expressed inflammation-related genes (DEIRGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed for DEIRGs. We then constructed the protein-protein interaction (PPI) network using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database and identified hub genes using the Cytoscape plugin MCODE. Finally, least absolute shrinkage and selection operator (LASSO) logistic regression was used to construct a diagnostic model. Results: A total of 1728 DEGs were identified between the TAAD and normal samples. Thereafter, 61 DEIRGs are obtained by taking the intersection of DEGs and inflammation-related genes. The GO indicated that DEIRGs were mainly enriched in response to lipopolysaccharide, in response to molecules of bacterial origin, secretory granule membrane, external side of plasma, receptor ligand activity, and signaling receptor activator activity. KEGG analysis indicated that DEIRGs were mainly enriched in cytokine-cytokine receptor interaction, TNF signaling pathway, and proteoglycans in cancer. We identified MYC, SELL, HIF1A, EDN1, SERPINE1, CCL20, IL1R1, NOD2, TLR2, CD69, PLAUR, MMP14, and HBEGF as hub genes using the MCODE plug-in. The ROC indicated these genes had a good diagnostic performance for TAAD. Conclusion: In conclusion, our study identified 13 hub genes in the TAAD. This study will be of significance for the future development of a preventive therapy of TAAD. | ||
| 650 | 4 | |a hub gene | |
| 650 | 4 | |a inflammation-related genes | |
| 650 | 4 | |a TAAD | |
| 700 | 1 | |a Zeng, Ziwei |d 1995- |e VerfasserIn |0 (DE-588)1286632560 |0 (DE-627)1843156342 |4 aut | |
| 700 | 1 | |a Yagublu, Vugar |d 1971- |e VerfasserIn |0 (DE-588)132389886 |0 (DE-627)52195441X |0 (DE-576)299115917 |4 aut | |
| 700 | 1 | |a Rahbari, Nuh Nabi |d 1980- |e VerfasserIn |0 (DE-588)132519356 |0 (DE-627)523331908 |0 (DE-576)299198464 |4 aut | |
| 700 | 1 | |a Reißfelder, Christoph |d 1975- |e VerfasserIn |0 (DE-588)1025566211 |0 (DE-627)722940297 |0 (DE-576)370516044 |4 aut | |
| 700 | 1 | |a Keese, Michael |d 1971- |e VerfasserIn |0 (DE-588)120713330 |0 (DE-627)704941805 |0 (DE-576)292352778 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Personalized Medicine |d Basel : MDPI, 2011 |g 13(2023), 6, Artikel-ID 990, Seite 1-17 |h Online-Ressource |w (DE-627)71862713X |w (DE-600)2662248-8 |w (DE-576)365413666 |x 2075-4426 |7 nnas |a Analysis of inflammation-related genes in patients with stanford type A aortic dissection |
| 773 | 1 | 8 | |g volume:13 |g year:2023 |g number:6 |g elocationid:990 |g pages:1-17 |g extent:17 |a Analysis of inflammation-related genes in patients with stanford type A aortic dissection |
| 856 | 4 | 0 | |u https://doi.org/10.3390/jpm13060990 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2075-4426/13/6/990 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240930 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 120713330 |a Keese, Michael |m 120713330:Keese, Michael |d 60000 |e 60000PK120713330 |k 0/60000/ |p 6 |y j | ||
| 998 | |g 1025566211 |a Reißfelder, Christoph |m 1025566211:Reißfelder, Christoph |d 60000 |d 61800 |d 50000 |e 60000PR1025566211 |e 61800PR1025566211 |e 50000PR1025566211 |k 0/60000/ |k 1/60000/61800/ |k 0/50000/ |p 5 | ||
| 998 | |g 132519356 |a Rahbari, Nuh Nabi |m 132519356:Rahbari, Nuh Nabi |d 60000 |d 61800 |e 60000PR132519356 |e 61800PR132519356 |k 0/60000/ |k 1/60000/61800/ |p 4 | ||
| 998 | |g 132389886 |a Yagublu, Vugar |m 132389886:Yagublu, Vugar |d 60000 |e 60000PY132389886 |k 0/60000/ |p 3 | ||
| 998 | |g 1286632560 |a Zeng, Ziwei |m 1286632560:Zeng, Ziwei |d 60000 |e 60000PZ1286632560 |k 0/60000/ |p 2 | ||
| 998 | |g 1296626865 |a Li, Lin |m 1296626865:Li, Lin |d 60000 |e 60000PL1296626865 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1903730643 |e 4584637598 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"note":["Gesehen am 18.06.20"],"id":{"eki":["71862713X"],"zdb":["2662248-8"],"issn":["2075-4426"]},"title":[{"title_sort":"Journal of Personalized Medicine","title":"Journal of Personalized Medicine","subtitle":"open access journal"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"71862713X","origin":[{"publisher":"MDPI","publisherPlace":"Basel","dateIssuedDisp":"2011-","dateIssuedKey":"2011"}],"disp":"Analysis of inflammation-related genes in patients with stanford type A aortic dissectionJournal of Personalized Medicine","language":["eng"],"pubHistory":["1.2011 -"],"part":{"text":"13(2023), 6, Artikel-ID 990, Seite 1-17","extent":"17","issue":"6","year":"2023","pages":"1-17","volume":"13"},"type":{"bibl":"periodical","media":"Online-Ressource"}}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"family":"Li","role":"aut","display":"Li, Lin","given":"Lin"},{"family":"Zeng","role":"aut","display":"Zeng, Ziwei","given":"Ziwei"},{"given":"Vugar","display":"Yagublu, Vugar","role":"aut","family":"Yagublu"},{"role":"aut","family":"Rahbari","given":"Nuh Nabi","display":"Rahbari, Nuh Nabi"},{"role":"aut","family":"Reißfelder","given":"Christoph","display":"Reißfelder, Christoph"},{"display":"Keese, Michael","given":"Michael","family":"Keese","role":"aut"}],"title":[{"title":"Analysis of inflammation-related genes in patients with stanford type A aortic dissection","title_sort":"Analysis of inflammation-related genes in patients with stanford type A aortic dissection"}],"note":["Gesehen am 30.09.2024"],"id":{"doi":["10.3390/jpm13060990"],"eki":["1903730643"]},"physDesc":[{"extent":"17 S."}],"name":{"displayForm":["Lin Li, Ziwei Zeng, Vugar Yagublu, Nuh Rahbari, Christoph Reißfelder and Michael Keese"]},"recId":"1903730643","origin":[{"dateIssuedKey":"2023","dateIssuedDisp":" 13 June 2023"}]} | ||
| SRT | |a LILINZENGZANALYSISOF1320 | ||