Impact of angiopoietin-2 on kidney diseases
Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostas...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2023
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| In: |
Kidney diseases
Year: 2023, Jahrgang: 9, Heft: 3, Pages: 143-156 |
| ISSN: | 2296-9357 |
| DOI: | 10.1159/000529774 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1159/000529774 Verlag, kostenfrei, Volltext: https://karger.com/kdd/article/9/3/143/835799/Impact-of-Angiopoietin-2-on-Kidney-Diseases 
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| Verfasserangaben: | Mei Li, Zoran Popovic, Chang Chu, Christoph Reichetzeder, Wolfgang Pommer, Bernhard K. Krämer, Berthold Hocher |
| Zusammenfassung: | Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostasis. While Ang-1 typically acts as the endothelium-protective mediator, its context-dependent antagonist Ang-2 can promote endothelium permeability and vascular destabilization, hence contributing to a poor outcome in vascular diseases via endothelial injury, vascular dysfunction, and microinflammation. The pathogenesis of kidney diseases is associated with endothelial dysfunction and chronic inflammation in renal diseases. Summary: Several preclinical studies report overexpression of Ang-2 in renal tissues of certain kidney disease models; additionally, clinical studies show increased levels of circulating Ang-2 in the course of chronic kidney disease, implying that Ang-2 may serve as a useful biomarker in these patients. However, the exact mechanisms of Ang-2 action in renal diseases remain unclear. Key Messages: We summarized the recent findings on Ang-2 in kidney diseases, including preclinical studies and clinical studies, aiming to provide a systematic understanding of the role of Ang-2 in these diseases. |
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| Beschreibung: | Online veröffentlicht: 14. März 2023 Gesehen am 30.09.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 2296-9357 |
| DOI: | 10.1159/000529774 |