Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish
Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and progenitor cells (HSPCs). Recent data point to tissue-specific EC specialization as well as heterogeneity; however, it remains unclear how ECs acquire these properties. Here, by combining live-imaging-based li...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 February 2023
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| In: |
Developmental cell
Year: 2023, Jahrgang: 58, Heft: 3, Pages: 224-238.e7 |
| ISSN: | 1878-1551 |
| DOI: | 10.1016/j.devcel.2022.12.013 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.devcel.2022.12.013 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1534580722008954 
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| Verfasserangaben: | Hiroyuki Nakajima, Hiroyuki Ishikawa, Takuya Yamamoto, Ayano Chiba, Hajime Fukui, Keisuke Sako, Moe Fukumoto, Kenny Mattonet, Hyouk-Bum Kwon, Subhra P. Hui, Gergana D. Dobreva, Kazu Kikuchi, Christian S.M. Helker, Didier Y.R. Stainier, Naoki Mochizuki |
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| 100 | 1 | |a Nakajima, Hiroyuki |e VerfasserIn |0 (DE-588)1343618487 |0 (DE-627)1903775582 |4 aut | |
| 245 | 1 | 0 | |a Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish |c Hiroyuki Nakajima, Hiroyuki Ishikawa, Takuya Yamamoto, Ayano Chiba, Hajime Fukui, Keisuke Sako, Moe Fukumoto, Kenny Mattonet, Hyouk-Bum Kwon, Subhra P. Hui, Gergana D. Dobreva, Kazu Kikuchi, Christian S.M. Helker, Didier Y.R. Stainier, Naoki Mochizuki |
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| 520 | |a Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and progenitor cells (HSPCs). Recent data point to tissue-specific EC specialization as well as heterogeneity; however, it remains unclear how ECs acquire these properties. Here, by combining live-imaging-based lineage-tracing and single-cell transcriptomics in zebrafish embryos, we identify an unexpected origin for part of the vascular HSPC niche. We find that islet1 (isl1)-expressing cells are the progenitors of the venous ECs that constitute the majority of the HSPC niche. These isl1-expressing cells surprisingly originate from the endoderm and differentiate into ECs in a process dependent on Bmp-Smad signaling and subsequently requiring npas4l (cloche) function. Single-cell RNA sequencing analyses show that isl1-derived ECs express a set of genes that reflect their distinct origin. This study demonstrates that endothelial specialization in the HSPC niche is determined at least in part by the origin of the ECs. | ||
| 650 | 4 | |a endothelial specialization | |
| 650 | 4 | |a hematopoietic stem and progenitor cell | |
| 650 | 4 | |a imaging-based lineage tracing | |
| 650 | 4 | |a vascular niche | |
| 700 | 1 | |a Ishikawa, Hiroyuki |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yamamoto, Takuya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chiba, Ayano |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fukui, Hajime |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sako, Keisuke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fukumoto, Moe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mattonet, Kenny |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kwon, Hyouk-Bum |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hui, Subhra P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dobreva, Gergana |d 1977- |e VerfasserIn |0 (DE-588)128752343 |0 (DE-627)379128888 |0 (DE-576)297314491 |4 aut | |
| 700 | 1 | |a Kikuchi, Kazu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Helker, Christian S. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stainier, Didier Y. R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mochizuki, Naoki |e VerfasserIn |4 aut | |
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