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Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication

The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the activation of one factor compensates for the inhibition of the other. Moreover, it is unkn...

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Main Authors: Liu, Kaijing (Author) , Wehling, Lilija (Author) , Wan, Shan (Author) , Weiler, Sofia Maria Elisabeth (Author) , Tóth, Marcell (Author) , Ibberson, David (Author) , Marhenke, Silke (Author) , Ali, Adnan (Author) , Lam, Macrina (Author) , Guo, Te (Author) , Pinna, Federico (Author) , Pedrini, Fabiola (Author) , Damle-Vartak, Amruta (Author) , Dropmann, Anne (Author) , Rose, Fabian (Author) , Colucci, Silvia (Author) , Cheng, Wenxiang (Author) , Bissinger, Michaela (Author) , Schmitt, Jennifer (Author) , Birner, Patrizia (Author) , Poth, Tanja (Author) , Angel, Peter (Author) , Dooley, Steven (Author) , Muckenthaler, Martina (Author) , Longerich, Thomas (Author) , Vogel, Arndt (Author) , Heikenwälder, Mathias (Author) , Schirmacher, Peter (Author) , Breuhahn, Kai (Author)
Format: Article (Journal)
Language:English
Published: 04 March 2024
In: Cellular and molecular life sciences
Year: 2024, Volume: 81, Issue: 1, Pages: 1-19
ISSN:1420-9071
DOI:10.1007/s00018-024-05126-1
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00018-024-05126-1
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00018-024-05126-1
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Author Notes:Kaijing Liu, Lilija Wehling, Shan Wan, Sofia M.E. Weiler, Marcell Tóth, David Ibberson, Silke Marhenke, Adnan Ali, Macrina Lam, Te Guo, Federico Pinna, Fabiola Pedrini, Amruta Damle-Vartak, Anne Dropmann, Fabian Rose, Silvia Colucci, Wenxiang Cheng, Michaela Bissinger, Jennifer Schmitt, Patrizia Birner, Tanja Poth, Peter Angel, Steven Dooley, Martina U. Muckenthaler, Thomas Longerich, Arndt Vogel, Mathias Heikenwälder, Peter Schirmacher, Kai Breuhahn
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Summary:The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the activation of one factor compensates for the inhibition of the other. Moreover, it is unknown if YAP/TAZ-directed perturbation affects cell-cell communication of non-malignant liver cells.
Item Description:Gesehen am 01.10.2024
Physical Description:Online Resource
ISSN:1420-9071
DOI:10.1007/s00018-024-05126-1

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