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Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma

Background: Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy. Methods: This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC i...

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Bibliographische Detailangaben
Hauptverfasser: Steen, Sonja (VerfasserIn) , Horn, Dominik (VerfasserIn) , Flechtenmacher, Christa (VerfasserIn) , Hoffmann, Jürgen (VerfasserIn) , Freier, Kolja (VerfasserIn) , Ristow, Oliver (VerfasserIn) , Heß, Jochen (VerfasserIn) , Moratin, Julius (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 August 2024
In: Head & neck
Year: 2024, Pages: 1-15
ISSN:1097-0347
DOI:10.1002/hed.27925
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/hed.27925
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.27925
Volltext
Verfasserangaben:Sonja Steen MD, DDS, Dominik Horn MD, DDS, Christa Flechtenmacher MD, Jürgen Hoffmann MD, DDS, Kolja Freier MD, DDS, Oliver Ristow MD, DDS, Jochen Hess PhD, Julius Moratin MD, DDS
Beschreibung
Zusammenfassung:Background: Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy. Methods: This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance. Results: We found a significant downregulation of SOX9 from primary disease to lymph node metastases (p < 0.001). SOX9 expression and the subgroup SOX2lowSOX9high were significantly correlated with worse overall survival (p < 0.05). Additionally, SOX2lowSOX9high expression pattern was confirmed as independent prognosticator for overall survival. Conclusions: These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.
Beschreibung:Gesehen am 07.10.2024
Beschreibung:Online Resource
ISSN:1097-0347
DOI:10.1002/hed.27925

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