Cover Image

Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma

Recent studies suggest that BRAFV600-mutated melanomas in particular respond to dual anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) immune checkpoint inhibition (ICI). Here we identified an over-representation of interleukin (IL)-17-type 17...

Full description

Saved in:
Bibliographic Details
Main Authors: Váraljai, Renáta (Author) , Zimmer, Lisa (Author) , Al-Matary, Yahya (Author) , Kaptein, Paulien (Author) , Albrecht, Lea J. (Author) , Shannan, Batool (Author) , Brase, Jan C. (Author) , Gusenleitner, Daniel (Author) , Amaral, Teresa (Author) , Wyss, Nina (Author) , Utikal, Jochen (Author) , Flatz, Lukas (Author) , Rambow, Florian (Author) , Reinhardt, Hans Christian (Author) , Dick, Jenny (Author) , Engel, Daniel R. (Author) , Horn, Susanne (Author) , Ugurel, Selma (Author) , Sondermann, Wiebke (Author) , Livingstone, Elisabeth (Author) , Sucker, Antje (Author) , Paschen, Annette (Author) , Zhao, Fang (Author) , Placke, Jan-Malte (Author) , Klose, Jasmin M. (Author) , Fendler, Wolfgang P. (Author) , Thommen, Daniela S. (Author) , Helfrich, Iris (Author) , Schadendorf, Dirk (Author) , Roesch, Alexander (Author)
Format: Article (Journal)
Language:English
Published: September 2023
In: Nature cancer
Year: 2023, Volume: 4, Issue: 9, Pages: 1292-1308
ISSN:2662-1347
DOI:10.1038/s43018-023-00610-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s43018-023-00610-2
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s43018-023-00610-2
Get full text
Author Notes:Renáta Váraljai, Lisa Zimmer, Yahya Al-Matary, Paulien Kaptein, Lea J. Albrecht, Batool Shannan, Jan C. Brase, Daniel Gusenleitner, Teresa Amaral, Nina Wyss, Jochen Utikal, Lukas Flatz, Florian Rambow, Hans Christian Reinhardt, Jenny Dick, Daniel R. Engel, Susanne Horn, Selma Ugurel, Wiebke Sondermann, Elisabeth Livingstone, Antje Sucker, Annette Paschen, Fang Zhao, Jan M. Placke, Jasmin M. Klose, Wolfgang P. Fendler, Daniela S. Thommen, Iris Helfrich, Dirk Schadendorf & Alexander Roesch

MARC

LEADER 00000caa a2200000 c 4500
001 1905058705
003 DE-627
005 20251111094019.0
007 cr uuu---uuuuu
008 241008s2023 xx |||||o 00| ||eng c
024 7 |a 10.1038/s43018-023-00610-2  |2 doi 
035 |a (DE-627)1905058705 
035 |a (DE-599)KXP1905058705 
035 |a (OCoLC)1475314357 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Váraljai, Renáta  |e VerfasserIn  |0 (DE-588)1200553365  |0 (DE-627)1683678028  |4 aut 
245 1 0 |a Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma  |c Renáta Váraljai, Lisa Zimmer, Yahya Al-Matary, Paulien Kaptein, Lea J. Albrecht, Batool Shannan, Jan C. Brase, Daniel Gusenleitner, Teresa Amaral, Nina Wyss, Jochen Utikal, Lukas Flatz, Florian Rambow, Hans Christian Reinhardt, Jenny Dick, Daniel R. Engel, Susanne Horn, Selma Ugurel, Wiebke Sondermann, Elisabeth Livingstone, Antje Sucker, Annette Paschen, Fang Zhao, Jan M. Placke, Jasmin M. Klose, Wolfgang P. Fendler, Daniela S. Thommen, Iris Helfrich, Dirk Schadendorf & Alexander Roesch 
264 1 |c September 2023 
300 |b Illustrationen 
300 |a 27 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 31. Juli 2023 
500 |a Gesehen am 08.10.2024 
520 |a Recent studies suggest that BRAFV600-mutated melanomas in particular respond to dual anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) immune checkpoint inhibition (ICI). Here we identified an over-representation of interleukin (IL)-17-type 17 helper T (TH17) gene expression signatures (GES) in BRAFV600-mutated tumors. Moreover, high baseline IL-17 GES consistently predicted clinical responses in dual-ICI-treated patient cohorts but not in mono anti-CTLA-4 or anti-PD-1 ICI cohorts. High IL-17 GES corresponded to tumor infiltration with T cells and neutrophils. Accordingly, high neutrophil infiltration correlated with clinical response specifically to dual ICI, and tumor-associated neutrophils also showed strong IL-17-TH17 pathway activity and T cell activation capacity. Both the blockade of IL-17A and the depletion of neutrophils impaired dual-ICI response and decreased T cell activation. Finally, high IL-17A levels in the blood of patients with melanoma indicated a higher global TH17 cytokine profile preceding clinical response to dual ICI but not to anti-PD-1 monotherapy, suggesting a future role as a biomarker for patient stratification. 
650 4 |a Cancer 
650 4 |a Cancer immunotherapy 
650 4 |a Melanoma 
650 4 |a Tumour immunology 
700 1 |a Zimmer, Lisa  |e VerfasserIn  |4 aut 
700 1 |a Al-Matary, Yahya  |e VerfasserIn  |4 aut 
700 1 |a Kaptein, Paulien  |e VerfasserIn  |4 aut 
700 1 |a Albrecht, Lea J.  |e VerfasserIn  |4 aut 
700 1 |a Shannan, Batool  |e VerfasserIn  |4 aut 
700 1 |a Brase, Jan C.  |e VerfasserIn  |4 aut 
700 1 |a Gusenleitner, Daniel  |e VerfasserIn  |4 aut 
700 1 |a Amaral, Teresa  |e VerfasserIn  |4 aut 
700 1 |a Wyss, Nina  |e VerfasserIn  |4 aut 
700 1 |a Utikal, Jochen  |d 1974-  |e VerfasserIn  |0 (DE-588)1026463750  |0 (DE-627)726765015  |0 (DE-576)371816580  |4 aut 
700 1 |a Flatz, Lukas  |e VerfasserIn  |4 aut 
700 1 |a Rambow, Florian  |e VerfasserIn  |4 aut 
700 1 |a Reinhardt, Hans Christian  |e VerfasserIn  |4 aut 
700 1 |8 1\p  |a Dick, Jenny  |e VerfasserIn  |0 (DE-588)1338901346  |0 (DE-627)1898601526  |4 aut 
700 1 |a Engel, Daniel R.  |e VerfasserIn  |4 aut 
700 1 |a Horn, Susanne  |e VerfasserIn  |4 aut 
700 1 |a Ugurel, Selma  |d 1971-  |e VerfasserIn  |0 (DE-588)122030923  |0 (DE-627)081693532  |0 (DE-576)293057567  |4 aut 
700 1 |8 2\p  |a Sondermann, Wiebke  |e VerfasserIn  |0 (DE-588)1198953756  |0 (DE-627)1681162121  |4 aut 
700 1 |a Livingstone, Elisabeth  |e VerfasserIn  |0 (DE-588)1049231325  |0 (DE-627)781379636  |0 (DE-576)403194016  |4 aut 
700 1 |a Sucker, Antje  |e VerfasserIn  |4 aut 
700 1 |a Paschen, Annette  |e VerfasserIn  |0 (DE-588)1076261353  |0 (DE-627)834584263  |0 (DE-576)445109475  |4 aut 
700 1 |a Zhao, Fang  |e VerfasserIn  |4 aut 
700 1 |a Placke, Jan-Malte  |e VerfasserIn  |0 (DE-588)1131806557  |0 (DE-627)886545293  |0 (DE-576)488493978  |4 aut 
700 1 |a Klose, Jasmin M.  |e VerfasserIn  |4 aut 
700 1 |a Fendler, Wolfgang P.  |e VerfasserIn  |4 aut 
700 1 |a Thommen, Daniela S.  |e VerfasserIn  |4 aut 
700 1 |a Helfrich, Iris  |e VerfasserIn  |0 (DE-588)1176221531  |0 (DE-627)1047376245  |0 (DE-576)516584871  |4 aut 
700 1 |a Schadendorf, Dirk  |d 1960-  |e VerfasserIn  |0 (DE-588)11142576X  |0 (DE-627)499566076  |0 (DE-576)289702275  |4 aut 
700 1 |a Roesch, Alexander  |d 1805-1851  |e VerfasserIn  |0 (DE-588)1227921047  |0 (DE-627)1749125625  |4 aut 
773 0 8 |i Enthalten in  |t Nature cancer  |d London : Nature Research, 2020  |g 4(2023), 9, Seite 1292-1308  |h Online-Ressource  |w (DE-627)1687330697  |w (DE-600)3005299-3  |x 2662-1347  |7 nnas  |a Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma 
773 1 8 |g volume:4  |g year:2023  |g number:9  |g pages:1292-1308  |g extent:27  |a Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma 
856 4 0 |u https://doi.org/10.1038/s43018-023-00610-2  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s43018-023-00610-2  |x Verlag  |z kostenfrei  |3 Volltext 
883 |8 1\p  |a cgwrk  |d 20250301  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
883 |8 2\p  |a cgwrk  |d 20250301  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
951 |a AR 
992 |a 20241008 
993 |a Article 
994 |a 2023 
998 |g 11142576X  |a Schadendorf, Dirk  |m 11142576X:Schadendorf, Dirk  |d 50000  |e 50000PS11142576X  |k 0/50000/  |p 29 
998 |g 1076261353  |a Paschen, Annette  |m 1076261353:Paschen, Annette  |d 50000  |e 50000PP1076261353  |k 0/50000/  |p 22 
998 |g 122030923  |a Ugurel, Selma  |m 122030923:Ugurel, Selma  |d 60000  |e 60000PU122030923  |k 0/60000/  |p 18 
998 |g 1026463750  |a Utikal, Jochen  |m 1026463750:Utikal, Jochen  |d 60000  |e 60000PU1026463750  |k 0/60000/  |p 11 
999 |a KXP-PPN1905058705  |e 4588884220 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Online veröffentlicht: 31. Juli 2023","Gesehen am 08.10.2024"],"title":[{"title_sort":"Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma","title":"Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma"}],"id":{"doi":["10.1038/s43018-023-00610-2"],"eki":["1905058705"]},"recId":"1905058705","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"September 2023"}],"relHost":[{"language":["eng"],"origin":[{"publisher":"Nature Research","dateIssuedDisp":"2020-","dateIssuedKey":"2020","publisherPlace":"London"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"volume":"4","issue":"9","text":"4(2023), 9, Seite 1292-1308","pages":"1292-1308","extent":"27","year":"2023"},"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["3005299-3"],"eki":["1687330697"],"issn":["2662-1347"]},"title":[{"title_sort":"Nature cancer","title":"Nature cancer"}],"disp":"Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanomaNature cancer","note":["Gesehen am 14.01.20"],"recId":"1687330697","pubHistory":["Volume 1, Issue 1, (January 2020)-"]}],"physDesc":[{"noteIll":"Illustrationen","extent":"27 S."}],"person":[{"given":"Renáta","display":"Váraljai, Renáta","role":"aut","roleDisplay":"VerfasserIn","family":"Váraljai"},{"display":"Zimmer, Lisa","role":"aut","given":"Lisa","roleDisplay":"VerfasserIn","family":"Zimmer"},{"given":"Yahya","display":"Al-Matary, Yahya","role":"aut","roleDisplay":"VerfasserIn","family":"Al-Matary"},{"given":"Paulien","role":"aut","display":"Kaptein, Paulien","roleDisplay":"VerfasserIn","family":"Kaptein"},{"display":"Albrecht, Lea J.","role":"aut","given":"Lea J.","roleDisplay":"VerfasserIn","family":"Albrecht"},{"family":"Shannan","roleDisplay":"VerfasserIn","role":"aut","display":"Shannan, Batool","given":"Batool"},{"roleDisplay":"VerfasserIn","family":"Brase","given":"Jan C.","role":"aut","display":"Brase, Jan C."},{"family":"Gusenleitner","roleDisplay":"VerfasserIn","role":"aut","display":"Gusenleitner, Daniel","given":"Daniel"},{"roleDisplay":"VerfasserIn","family":"Amaral","display":"Amaral, Teresa","role":"aut","given":"Teresa"},{"display":"Wyss, Nina","role":"aut","given":"Nina","roleDisplay":"VerfasserIn","family":"Wyss"},{"family":"Utikal","roleDisplay":"VerfasserIn","role":"aut","display":"Utikal, Jochen","given":"Jochen"},{"given":"Lukas","display":"Flatz, Lukas","role":"aut","roleDisplay":"VerfasserIn","family":"Flatz"},{"roleDisplay":"VerfasserIn","family":"Rambow","role":"aut","display":"Rambow, Florian","given":"Florian"},{"roleDisplay":"VerfasserIn","family":"Reinhardt","display":"Reinhardt, Hans Christian","role":"aut","given":"Hans Christian"},{"family":"Dick","roleDisplay":"VerfasserIn","given":"Jenny","role":"aut","display":"Dick, Jenny"},{"role":"aut","display":"Engel, Daniel R.","given":"Daniel R.","roleDisplay":"VerfasserIn","family":"Engel"},{"display":"Horn, Susanne","role":"aut","given":"Susanne","family":"Horn","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Ugurel, Selma","given":"Selma","family":"Ugurel","roleDisplay":"VerfasserIn"},{"family":"Sondermann","roleDisplay":"VerfasserIn","given":"Wiebke","display":"Sondermann, Wiebke","role":"aut"},{"role":"aut","display":"Livingstone, Elisabeth","given":"Elisabeth","roleDisplay":"VerfasserIn","family":"Livingstone"},{"given":"Antje","role":"aut","display":"Sucker, Antje","family":"Sucker","roleDisplay":"VerfasserIn"},{"given":"Annette","display":"Paschen, Annette","role":"aut","family":"Paschen","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Zhao","given":"Fang","display":"Zhao, Fang","role":"aut"},{"family":"Placke","roleDisplay":"VerfasserIn","display":"Placke, Jan-Malte","role":"aut","given":"Jan-Malte"},{"roleDisplay":"VerfasserIn","family":"Klose","given":"Jasmin M.","role":"aut","display":"Klose, Jasmin M."},{"given":"Wolfgang P.","display":"Fendler, Wolfgang P.","role":"aut","roleDisplay":"VerfasserIn","family":"Fendler"},{"role":"aut","display":"Thommen, Daniela S.","given":"Daniela S.","family":"Thommen","roleDisplay":"VerfasserIn"},{"display":"Helfrich, Iris","role":"aut","given":"Iris","family":"Helfrich","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Schadendorf","given":"Dirk","display":"Schadendorf, Dirk","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Roesch","given":"Alexander","role":"aut","display":"Roesch, Alexander"}],"name":{"displayForm":["Renáta Váraljai, Lisa Zimmer, Yahya Al-Matary, Paulien Kaptein, Lea J. Albrecht, Batool Shannan, Jan C. Brase, Daniel Gusenleitner, Teresa Amaral, Nina Wyss, Jochen Utikal, Lukas Flatz, Florian Rambow, Hans Christian Reinhardt, Jenny Dick, Daniel R. Engel, Susanne Horn, Selma Ugurel, Wiebke Sondermann, Elisabeth Livingstone, Antje Sucker, Annette Paschen, Fang Zhao, Jan M. Placke, Jasmin M. Klose, Wolfgang P. Fendler, Daniela S. Thommen, Iris Helfrich, Dirk Schadendorf & Alexander Roesch"]}} 
SRT |a VARALJAIREINTERLEUKI2023 

Similar Items