A shared neural basis underlying psychiatric comorbidity
Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAG...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2023
|
| In: |
Nature medicine
Year: 2023, Jahrgang: 29, Heft: 5, Pages: 1232-1242 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/s41591-023-02317-4 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41591-023-02317-4 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41591-023-02317-4 |
| Verfasserangaben: | Chao Xie, Shitong Xiang, Chun Shen, Xuerui Peng, Jujiao Kang, Yuzhu Li, Wei Cheng, Shiqi He, Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Ulrike Schmidt, Julia Sinclair, Michael N. Smolka, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières, Barbara J. Sahakian, Trevor W. Robbins, Gunter Schumann, Tianye Jia, Jianfeng Feng, IMAGEN Consortium, STRATIFY/ESTRA Consortium & ZIB Consortium |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1905548443 | ||
| 003 | DE-627 | ||
| 005 | 20250325232021.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241014s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41591-023-02317-4 |2 doi | |
| 035 | |a (DE-627)1905548443 | ||
| 035 | |a (DE-599)KXP1905548443 | ||
| 035 | |a (OCoLC)1475314999 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Xie, Chao |e VerfasserIn |0 (DE-588)1236880242 |0 (DE-627)176271535X |4 aut | |
| 245 | 1 | 2 | |a A shared neural basis underlying psychiatric comorbidity |c Chao Xie, Shitong Xiang, Chun Shen, Xuerui Peng, Jujiao Kang, Yuzhu Li, Wei Cheng, Shiqi He, Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Ulrike Schmidt, Julia Sinclair, Michael N. Smolka, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières, Barbara J. Sahakian, Trevor W. Robbins, Gunter Schumann, Tianye Jia, Jianfeng Feng, IMAGEN Consortium, STRATIFY/ESTRA Consortium & ZIB Consortium |
| 264 | 1 | |c May 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 25 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 24. April 2023 | ||
| 500 | |a Gesehen am 14.10.2024 | ||
| 520 | |a Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities. | ||
| 650 | 4 | |a Cognitive control | |
| 650 | 4 | |a Psychiatric disorders | |
| 700 | 1 | |8 1\p |a Xiang, Shitong |e VerfasserIn |0 (DE-588)1325824895 |0 (DE-627)1885589255 |4 aut | |
| 700 | 1 | |a Shen, Chun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peng, Xuerui |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kang, Jujiao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Li, Yuzhu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cheng, Wei |e VerfasserIn |4 aut | |
| 700 | 1 | |a He, Shiqi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bobou, Marina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Broulidakis, M. John |e VerfasserIn |4 aut | |
| 700 | 1 | |a van Noort, Betteke Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Zuo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Robinson, Lauren |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vaidya, Nilakshi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Winterer, Jeanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Yuning |e VerfasserIn |4 aut | |
| 700 | 1 | |a King, Sinead |e VerfasserIn |4 aut | |
| 700 | 1 | |a Banaschewski, Tobias |d 1961- |e VerfasserIn |0 (DE-588)115856110 |0 (DE-627)507227301 |0 (DE-576)178364703 |4 aut | |
| 700 | 1 | |a Barker, Gareth J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bokde, Arun L. W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bromberg, Uli |e VerfasserIn |4 aut | |
| 700 | 1 | |a Büchel, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Flor, Herta |d 1954- |e VerfasserIn |0 (DE-588)110841816 |0 (DE-627)636273695 |0 (DE-576)160967732 |4 aut | |
| 700 | 1 | |a Grigis, Antoine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Garavan, Hugh |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gowland, Penny |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heinz, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ittermann, Bernd |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lemaître, Hervé |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinot, Jean-Luc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinot, Marie-Laure Paillère |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nees, Frauke |e VerfasserIn |0 (DE-588)140286527 |0 (DE-627)703627244 |0 (DE-576)325389764 |4 aut | |
| 700 | 1 | |a Orfanos, Dimitri Papadopoulos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paus, Tomáš |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poustka, Luise |e VerfasserIn |0 (DE-588)1032378239 |0 (DE-627)738388688 |0 (DE-576)380005190 |4 aut | |
| 700 | 1 | |a Fröhner, Juliane H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmidt, Ulrike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sinclair, Julia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Smolka, Michael N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stringaris, Argyris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Walter, Henrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Whelan, Robert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Desrivières, Sylvane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sahakian, Barbara J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Robbins, Trevor W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schumann, Gunter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jia, Tianye |e VerfasserIn |4 aut | |
| 700 | 1 | |a Feng, Jianfeng |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature medicine |d [New York, NY] : Springer Nature, 1995 |g 29(2023), 5, Seite 1232-1242 |h Online-Ressource |w (DE-627)301511640 |w (DE-600)1484517-9 |w (DE-576)288571274 |x 1546-170X |7 nnas |a A shared neural basis underlying psychiatric comorbidity |
| 773 | 1 | 8 | |g volume:29 |g year:2023 |g number:5 |g pages:1232-1242 |g extent:25 |a A shared neural basis underlying psychiatric comorbidity |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41591-023-02317-4 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41591-023-02317-4 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20241014 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1032378239 |a Poustka, Luise |m 1032378239:Poustka, Luise |d 910000 |d 910600 |e 910000PP1032378239 |e 910600PP1032378239 |k 0/910000/ |k 1/910000/910600/ |p 35 |y j | ||
| 998 | |g 140286527 |a Nees, Frauke |m 140286527:Nees, Frauke |p 32 | ||
| 998 | |g 110841816 |a Flor, Herta |m 110841816:Flor, Herta |d 60000 |e 60000PF110841816 |k 0/60000/ |p 23 | ||
| 998 | |g 115856110 |a Banaschewski, Tobias |m 115856110:Banaschewski, Tobias |d 60000 |e 60000PB115856110 |k 0/60000/ |p 18 | ||
| 999 | |a KXP-PPN1905548443 |e 4594835511 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"family":"Xie","display":"Xie, Chao","given":"Chao","role":"aut"},{"given":"Shitong","role":"aut","family":"Xiang","display":"Xiang, Shitong"},{"given":"Chun","role":"aut","family":"Shen","display":"Shen, Chun"},{"family":"Peng","display":"Peng, Xuerui","role":"aut","given":"Xuerui"},{"display":"Kang, Jujiao","family":"Kang","given":"Jujiao","role":"aut"},{"display":"Li, Yuzhu","family":"Li","given":"Yuzhu","role":"aut"},{"role":"aut","given":"Wei","display":"Cheng, Wei","family":"Cheng"},{"display":"He, Shiqi","family":"He","given":"Shiqi","role":"aut"},{"given":"Marina","role":"aut","display":"Bobou, Marina","family":"Bobou"},{"role":"aut","given":"M. John","display":"Broulidakis, M. John","family":"Broulidakis"},{"display":"van Noort, Betteke Maria","family":"van Noort","given":"Betteke Maria","role":"aut"},{"given":"Zuo","role":"aut","display":"Zhang, Zuo","family":"Zhang"},{"given":"Lauren","role":"aut","display":"Robinson, Lauren","family":"Robinson"},{"given":"Nilakshi","role":"aut","family":"Vaidya","display":"Vaidya, Nilakshi"},{"family":"Winterer","display":"Winterer, Jeanne","role":"aut","given":"Jeanne"},{"display":"Zhang, Yuning","family":"Zhang","role":"aut","given":"Yuning"},{"role":"aut","given":"Sinead","family":"King","display":"King, Sinead"},{"display":"Banaschewski, Tobias","family":"Banaschewski","role":"aut","given":"Tobias"},{"given":"Gareth J.","role":"aut","family":"Barker","display":"Barker, Gareth J."},{"role":"aut","given":"Arun L. W.","family":"Bokde","display":"Bokde, Arun L. W."},{"display":"Bromberg, Uli","family":"Bromberg","given":"Uli","role":"aut"},{"given":"Christian","role":"aut","family":"Büchel","display":"Büchel, Christian"},{"role":"aut","given":"Herta","family":"Flor","display":"Flor, Herta"},{"given":"Antoine","role":"aut","display":"Grigis, Antoine","family":"Grigis"},{"family":"Garavan","display":"Garavan, Hugh","given":"Hugh","role":"aut"},{"family":"Gowland","display":"Gowland, Penny","role":"aut","given":"Penny"},{"role":"aut","given":"Andreas","family":"Heinz","display":"Heinz, Andreas"},{"given":"Bernd","role":"aut","family":"Ittermann","display":"Ittermann, Bernd"},{"family":"Lemaître","display":"Lemaître, Hervé","role":"aut","given":"Hervé"},{"family":"Martinot","display":"Martinot, Jean-Luc","given":"Jean-Luc","role":"aut"},{"given":"Marie-Laure Paillère","role":"aut","display":"Martinot, Marie-Laure Paillère","family":"Martinot"},{"family":"Nees","display":"Nees, Frauke","role":"aut","given":"Frauke"},{"display":"Orfanos, Dimitri Papadopoulos","family":"Orfanos","role":"aut","given":"Dimitri Papadopoulos"},{"given":"Tomáš","role":"aut","family":"Paus","display":"Paus, Tomáš"},{"given":"Luise","role":"aut","family":"Poustka","display":"Poustka, Luise"},{"role":"aut","given":"Juliane H.","display":"Fröhner, Juliane H.","family":"Fröhner"},{"role":"aut","given":"Ulrike","display":"Schmidt, Ulrike","family":"Schmidt"},{"given":"Julia","role":"aut","family":"Sinclair","display":"Sinclair, Julia"},{"given":"Michael N.","role":"aut","display":"Smolka, Michael N.","family":"Smolka"},{"family":"Stringaris","display":"Stringaris, Argyris","given":"Argyris","role":"aut"},{"family":"Walter","display":"Walter, Henrik","role":"aut","given":"Henrik"},{"family":"Whelan","display":"Whelan, Robert","role":"aut","given":"Robert"},{"display":"Desrivières, Sylvane","family":"Desrivières","given":"Sylvane","role":"aut"},{"family":"Sahakian","display":"Sahakian, Barbara J.","role":"aut","given":"Barbara J."},{"role":"aut","given":"Trevor W.","display":"Robbins, Trevor W.","family":"Robbins"},{"role":"aut","given":"Gunter","display":"Schumann, Gunter","family":"Schumann"},{"display":"Jia, Tianye","family":"Jia","role":"aut","given":"Tianye"},{"role":"aut","given":"Jianfeng","family":"Feng","display":"Feng, Jianfeng"}],"id":{"doi":["10.1038/s41591-023-02317-4"],"eki":["1905548443"]},"recId":"1905548443","relHost":[{"language":["eng"],"part":{"extent":"25","volume":"29","text":"29(2023), 5, Seite 1232-1242","issue":"5","year":"2023","pages":"1232-1242"},"recId":"301511640","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["301511640"],"issn":["1546-170X"],"zdb":["1484517-9"]},"title":[{"title":"Nature medicine","title_sort":"Nature medicine"}],"note":["Gesehen am 24. Juli 2018"],"pubHistory":["1.1995 -"],"origin":[{"dateIssuedDisp":"2017-","dateIssuedKey":"2017","publisher":"Springer Nature ; Nature America Inc.","publisherPlace":"[New York, NY] ; New York, NY"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"A shared neural basis underlying psychiatric comorbidityNature medicine"}],"name":{"displayForm":["Chao Xie, Shitong Xiang, Chun Shen, Xuerui Peng, Jujiao Kang, Yuzhu Li, Wei Cheng, Shiqi He, Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Ulrike Schmidt, Julia Sinclair, Michael N. Smolka, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières, Barbara J. Sahakian, Trevor W. Robbins, Gunter Schumann, Tianye Jia, Jianfeng Feng, IMAGEN Consortium, STRATIFY/ESTRA Consortium & ZIB Consortium"]},"physDesc":[{"extent":"25 S.","noteIll":"Illustrationen"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"May 2023"}],"note":["Online veröffentlicht: 24. April 2023","Gesehen am 14.10.2024"],"title":[{"title_sort":"shared neural basis underlying psychiatric comorbidity","title":"A shared neural basis underlying psychiatric comorbidity"}]} | ||
| SRT | |a XIECHAOXIASHAREDNEUR2023 | ||