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Thermostable WW-domain scaffold to design functional β-sheet miniproteins

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There has been a recent surge in the design of miniproteins for medicinal chemistry, biomaterial design, or synthetic biology. In particular, there is an interest in peptide scaffolds that fold reliably, predictably, and with solid stability. In this article, we present the design of a highly thermo...

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Main Authors: Lindner, Christina (Author) , Friemel, Anke (Author) , Schwegler, Niklas (Author) , Timmermann, Lisa (Author) , Pham, Truc Lam (Author) , Reusche, Vanessa (Author) , Kovermann, Michael (Author) , Thomas, Franziska (Author)
Format: Article (Journal)
Language:English
Published: June 10, 2024
In: Journal of the American Chemical Society
Year: 2024, Volume: 146, Issue: 24, Pages: 16590-16600
ISSN:1520-5126
DOI:10.1021/jacs.4c03498
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/jacs.4c03498
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Author Notes:Christina Lindner, Anke Friemel, Niklas Schwegler, Lisa Timmermann, Truc Lam Pham, Vanessa Reusche, Michael Kovermann, and Franziska Thomas
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