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Serotonin is a common thread linking different classes of antidepressants

Depression pathology remains elusive. The monoamine hypothesis has placed much focus on serotonin, but due to the variable clinical efficacy of monoamine reuptake inhibitors, the community is looking for alternative therapies such as ketamine (neurogenesis theory of antidepressant action). There is...

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Hauptverfasser: Witt, Colby E. (VerfasserIn) , Mena, Sergio (VerfasserIn) , Holmes, Jordan (VerfasserIn) , Hersey, Melinda (VerfasserIn) , Buchanan, Anna Marie (VerfasserIn) , Parke, Brenna (VerfasserIn) , Saylor, Rachel (VerfasserIn) , Honan, Lauren E. (VerfasserIn) , Berger, Shane N. (VerfasserIn) , Lumbreras, Sara (VerfasserIn) , Nijhout, Frederik H. (VerfasserIn) , Reed, Michael C. (VerfasserIn) , Best, Janet (VerfasserIn) , Fadel, James (VerfasserIn) , Schloss, Patrick (VerfasserIn) , Lau, Thorsten (VerfasserIn) , Hashemi, Parastoo (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 21, 2023
In: Cell chemical biology
Year: 2023, Jahrgang: 30, Heft: 12, Pages: 1557-1570, e1-6
ISSN:2451-9448
DOI:10.1016/j.chembiol.2023.10.009
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.chembiol.2023.10.009
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2451945623003707
Volltext
Verfasserangaben:Colby E. Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E. Honan, Shane N. Berger, Sara Lumbreras, Frederik H. Nijhout, Michael C. Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, and Parastoo Hashemi
Beschreibung
Zusammenfassung:Depression pathology remains elusive. The monoamine hypothesis has placed much focus on serotonin, but due to the variable clinical efficacy of monoamine reuptake inhibitors, the community is looking for alternative therapies such as ketamine (neurogenesis theory of antidepressant action). There is evidence that different classes of antidepressants may affect serotonin levels; a notion we test here. We measure hippocampal serotonin in mice with voltammetry and study the effects of acute challenges of escitalopram, fluoxetine, reboxetine, and ketamine. We find that pseudo-equivalent doses of these drugs similarly raise ambient serotonin levels, despite their differing pharmacodynamics because of differences in Uptake 1 and 2, rapid SERT trafficking, and modulation of serotonin by histamine. These antidepressants have different pharmacodynamics but have strikingly similar effects on extracellular serotonin. Our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis, and the monoamine hypothesis).
Beschreibung:Online verfügbar: 21. November 2023, Artikelversion: 21. Dezember 2023
Gesehen am 14.10.2024
Beschreibung:Online Resource
ISSN:2451-9448
DOI:10.1016/j.chembiol.2023.10.009

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