Immunomodulatory mechanisms and therapeutic potential of mesenchymal stem cells
Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, an...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2023
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| In: |
Stem cell reviews and reports
Year: 2023, Jahrgang: 19, Heft: 5, Pages: 1214-1231 |
| ISSN: | 2629-3277 |
| DOI: | 10.1007/s12015-023-10539-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12015-023-10539-9 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s12015-023-10539-9 
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| Verfasserangaben: | Guoqiang Yang, Xuehui Fan, Yingchun Liu, Pingping Jie, Maryam Mazhar, Yong Liu, Nathupakorn Dechsupa, Li Wang |
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| 520 | |a Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironmental factors to influence them. Previous studies have reported that the immunomodulatory role of MSCs is basically dependent on their secretion ability from MSCs. This review discusses the immunomodulatory capabilities of MSCs and the promising strategies to successfully improve the potential utilization of MSCs in clinical research. | ||
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