Nirogacestat, a γ-secretase inhibitor for desmoid tumors
In a randomized, placebo-controlled trial, oral nirogacestat twice daily led to 41% of patients having a tumor response, and 2-year progression-free survival was 76%. Most adverse events were low grade.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 09, 2023
|
| In: |
The New England journal of medicine
Year: 2023, Jahrgang: 388, Heft: 10, Pages: 898-912 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa2210140 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2210140 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2210140 
|
| Verfasserangaben: | Mrinal Gounder, Ravin Ratan, Thierry Alcindor, Patrick Schöffski, Winette T. van der Graaf, Breelyn A. Wilky, Richard F. Riedel, Allison Lim, L. Mary Smith, Stephanie Moody, Steven Attia, Sant Chawla, Gina D’Amato, Noah Federman, Priscilla Merriam, Brian A. Van Tine, Bruno Vincenzi, Charlotte Benson, Nam Quoc Bui, Rashmi Chugh, Gabriel Tinoco, John Charlson, Palma Dileo, Lee Hartner, Lore Lapeire, Filomena Mazzeo, Emanuela Palmerini, Peter Reichardt, Silvia Stacchiotti, Howard H. Bailey, Melissa A. Burgess, Gregory M. Cote, Lara E. Davis, Hari Deshpande, Hans Gelderblom, Giovanni Grignani, Elizabeth Loggers, Tony Philip, Joseph G. Pressey, Shivaani Kummar, and Bernd Kasper |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1905689276 | ||
| 003 | DE-627 | ||
| 005 | 20241205181109.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241015s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1056/NEJMoa2210140 |2 doi | |
| 035 | |a (DE-627)1905689276 | ||
| 035 | |a (DE-599)KXP1905689276 | ||
| 035 | |a (OCoLC)1475315589 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gounder, Mrinal M. |e VerfasserIn |0 (DE-588)127281971X |0 (DE-627)1822518873 |4 aut | |
| 245 | 1 | 0 | |a Nirogacestat, a γ-secretase inhibitor for desmoid tumors |c Mrinal Gounder, Ravin Ratan, Thierry Alcindor, Patrick Schöffski, Winette T. van der Graaf, Breelyn A. Wilky, Richard F. Riedel, Allison Lim, L. Mary Smith, Stephanie Moody, Steven Attia, Sant Chawla, Gina D’Amato, Noah Federman, Priscilla Merriam, Brian A. Van Tine, Bruno Vincenzi, Charlotte Benson, Nam Quoc Bui, Rashmi Chugh, Gabriel Tinoco, John Charlson, Palma Dileo, Lee Hartner, Lore Lapeire, Filomena Mazzeo, Emanuela Palmerini, Peter Reichardt, Silvia Stacchiotti, Howard H. Bailey, Melissa A. Burgess, Gregory M. Cote, Lara E. Davis, Hari Deshpande, Hans Gelderblom, Giovanni Grignani, Elizabeth Loggers, Tony Philip, Joseph G. Pressey, Shivaani Kummar, and Bernd Kasper |
| 246 | 3 | 3 | |a Nirogacestat, a gamma-secretase inhibitor for desmoid tumors |
| 264 | 1 | |c March 09, 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlich: 8. März 2023 | ||
| 500 | |a Gesehen am 15.10.2024 | ||
| 520 | |a In a randomized, placebo-controlled trial, oral nirogacestat twice daily led to 41% of patients having a tumor response, and 2-year progression-free survival was 76%. Most adverse events were low grade. | ||
| 700 | 1 | |a Ratan, Ravin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alcindor, Thierry |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schöffski, Patrick |e VerfasserIn |4 aut | |
| 700 | 1 | |a Graaf, Winette T. van der |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wilky, Breelyn A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Riedel, Richard F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lim, Allison |e VerfasserIn |4 aut | |
| 700 | 1 | |a Smith, L. Mary |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moody, Stephanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Attia, Steven |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chawla, Sant |e VerfasserIn |4 aut | |
| 700 | 1 | |a D’Amato, Gina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Federman, Noah |e VerfasserIn |4 aut | |
| 700 | 1 | |a Merriam, Priscilla |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tine, Brian A. Van |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vincenzi, Bruno |e VerfasserIn |4 aut | |
| 700 | 1 | |a Benson, Charlotte |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bui, Nam Quoc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chugh, Rashmi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tinoco, Gabriel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Charlson, John |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dileo, Palma |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hartner, Lee |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lapeire, Lore |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mazzeo, Filomena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Palmerini, Emanuela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reichardt, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stacchiotti, Silvia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bailey, Howard H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Burgess, Melissa A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cote, Gregory M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Davis, Lara E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Deshpande, Hari |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gelderblom, Hans |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grignani, Giovanni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Loggers, Elizabeth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Philip, Tony |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pressey, Joseph G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kummar, Shivaani |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kasper, Bernd |d 1974- |e VerfasserIn |0 (DE-588)12274764X |0 (DE-627)082130736 |0 (DE-576)29340447X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The New England journal of medicine |d Waltham, Mass. : MMS, 1928 |g 388(2023), 10, Seite 898-912 |h Online-Ressource |w (DE-627)266889484 |w (DE-600)1468837-2 |w (DE-576)075962454 |x 1533-4406 |7 nnas |a Nirogacestat, a γ-secretase inhibitor for desmoid tumors |
| 773 | 1 | 8 | |g volume:388 |g year:2023 |g number:10 |g pages:898-912 |g extent:15 |a Nirogacestat, a γ-secretase inhibitor for desmoid tumors |
| 856 | 4 | 0 | |u https://doi.org/10.1056/NEJMoa2210140 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nejm.org/doi/full/10.1056/NEJMoa2210140 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241015 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 12274764X |a Kasper, Bernd |m 12274764X:Kasper, Bernd |d 60000 |e 60000PK12274764X |k 0/60000/ |p 41 |y j | ||
| 999 | |a KXP-PPN1905689276 |e 4595267630 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title":"Nirogacestat, a γ-secretase inhibitor for desmoid tumors","title_sort":"Nirogacestat, a γ-secretase inhibitor for desmoid tumors"}],"name":{"displayForm":["Mrinal Gounder, Ravin Ratan, Thierry Alcindor, Patrick Schöffski, Winette T. van der Graaf, Breelyn A. Wilky, Richard F. Riedel, Allison Lim, L. Mary Smith, Stephanie Moody, Steven Attia, Sant Chawla, Gina D’Amato, Noah Federman, Priscilla Merriam, Brian A. Van Tine, Bruno Vincenzi, Charlotte Benson, Nam Quoc Bui, Rashmi Chugh, Gabriel Tinoco, John Charlson, Palma Dileo, Lee Hartner, Lore Lapeire, Filomena Mazzeo, Emanuela Palmerini, Peter Reichardt, Silvia Stacchiotti, Howard H. Bailey, Melissa A. Burgess, Gregory M. Cote, Lara E. Davis, Hari Deshpande, Hans Gelderblom, Giovanni Grignani, Elizabeth Loggers, Tony Philip, Joseph G. Pressey, Shivaani Kummar, and Bernd Kasper"]},"person":[{"family":"Gounder","role":"aut","given":"Mrinal M.","display":"Gounder, Mrinal M."},{"family":"Ratan","role":"aut","given":"Ravin","display":"Ratan, Ravin"},{"family":"Alcindor","display":"Alcindor, Thierry","given":"Thierry","role":"aut"},{"role":"aut","given":"Patrick","display":"Schöffski, Patrick","family":"Schöffski"},{"family":"Graaf","given":"Winette T. van der","role":"aut","display":"Graaf, Winette T. van der"},{"family":"Wilky","display":"Wilky, Breelyn A.","given":"Breelyn A.","role":"aut"},{"family":"Riedel","display":"Riedel, Richard F.","given":"Richard F.","role":"aut"},{"family":"Lim","role":"aut","given":"Allison","display":"Lim, Allison"},{"family":"Smith","display":"Smith, L. Mary","given":"L. Mary","role":"aut"},{"display":"Moody, Stephanie","role":"aut","given":"Stephanie","family":"Moody"},{"family":"Attia","display":"Attia, Steven","given":"Steven","role":"aut"},{"family":"Chawla","display":"Chawla, Sant","given":"Sant","role":"aut"},{"family":"D’Amato","given":"Gina","role":"aut","display":"D’Amato, Gina"},{"display":"Federman, Noah","given":"Noah","role":"aut","family":"Federman"},{"family":"Merriam","role":"aut","given":"Priscilla","display":"Merriam, Priscilla"},{"family":"Tine","role":"aut","given":"Brian A. Van","display":"Tine, Brian A. Van"},{"family":"Vincenzi","display":"Vincenzi, Bruno","given":"Bruno","role":"aut"},{"role":"aut","given":"Charlotte","display":"Benson, Charlotte","family":"Benson"},{"display":"Bui, Nam Quoc","role":"aut","given":"Nam Quoc","family":"Bui"},{"family":"Chugh","display":"Chugh, Rashmi","given":"Rashmi","role":"aut"},{"family":"Tinoco","display":"Tinoco, Gabriel","given":"Gabriel","role":"aut"},{"family":"Charlson","display":"Charlson, John","role":"aut","given":"John"},{"family":"Dileo","display":"Dileo, Palma","given":"Palma","role":"aut"},{"display":"Hartner, Lee","given":"Lee","role":"aut","family":"Hartner"},{"display":"Lapeire, Lore","role":"aut","given":"Lore","family":"Lapeire"},{"family":"Mazzeo","given":"Filomena","role":"aut","display":"Mazzeo, Filomena"},{"family":"Palmerini","display":"Palmerini, Emanuela","given":"Emanuela","role":"aut"},{"family":"Reichardt","display":"Reichardt, Peter","given":"Peter","role":"aut"},{"display":"Stacchiotti, Silvia","role":"aut","given":"Silvia","family":"Stacchiotti"},{"family":"Bailey","role":"aut","given":"Howard H.","display":"Bailey, Howard H."},{"given":"Melissa A.","role":"aut","display":"Burgess, Melissa A.","family":"Burgess"},{"role":"aut","given":"Gregory M.","display":"Cote, Gregory M.","family":"Cote"},{"family":"Davis","given":"Lara E.","role":"aut","display":"Davis, Lara E."},{"family":"Deshpande","display":"Deshpande, Hari","role":"aut","given":"Hari"},{"family":"Gelderblom","display":"Gelderblom, Hans","role":"aut","given":"Hans"},{"display":"Grignani, Giovanni","role":"aut","given":"Giovanni","family":"Grignani"},{"family":"Loggers","role":"aut","given":"Elizabeth","display":"Loggers, Elizabeth"},{"family":"Philip","given":"Tony","role":"aut","display":"Philip, Tony"},{"family":"Pressey","display":"Pressey, Joseph G.","role":"aut","given":"Joseph G."},{"given":"Shivaani","role":"aut","display":"Kummar, Shivaani","family":"Kummar"},{"role":"aut","given":"Bernd","display":"Kasper, Bernd","family":"Kasper"}],"origin":[{"dateIssuedDisp":"March 09, 2023","dateIssuedKey":"2023"}],"recId":"1905689276","titleAlt":[{"title":"Nirogacestat, a gamma-secretase inhibitor for desmoid tumors"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online veröffentlich: 8. März 2023","Gesehen am 15.10.2024"],"relHost":[{"titleAlt":[{"title":"NEJM"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"266889484","origin":[{"dateIssuedDisp":"1928-","publisher":"MMS ; MMS","dateIssuedKey":"1928","publisherPlace":"Waltham, Mass. ; Boston, Mass."}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Nirogacestat, a γ-secretase inhibitor for desmoid tumorsThe New England journal of medicine","id":{"eki":["266889484"],"issn":["1533-4406"],"zdb":["1468837-2"]},"corporate":[{"display":"Massachusetts Medical Society","role":"isb"}],"note":["Gesehen am 04.08.25"],"name":{"displayForm":["Massachusetts Medical Society"]},"pubHistory":["198.1928 -"],"title":[{"subtitle":"NEJM","title":"The New England journal of medicine","title_sort":"New England journal of medicine"}],"part":{"text":"388(2023), 10, Seite 898-912","year":"2023","volume":"388","pages":"898-912","extent":"15","issue":"10"},"language":["eng"]}],"id":{"eki":["1905689276"],"doi":["10.1056/NEJMoa2210140"]},"physDesc":[{"noteIll":"Illustrationen","extent":"15 S."}]} | ||
| SRT | |a GOUNDERMRINIROGACEST0920 | ||