Deficiency of Stabilin-1 in the context of hepatic melanoma metastasis
Background: This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models. Methods: In Stabilin-1−/− mice (Stab1 KO), liver colonization of B16F10 luc2 and Wt31 melanoma was investigated. The numbers, morphology, and vascularization of hepatic metastases and t...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 January 2024
|
| In: |
Cancers
Year: 2024, Jahrgang: 16, Heft: 2, Pages: 1-14 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16020441 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16020441 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/2/441 
|
| Verfasserangaben: | Sebastian A. Wohlfeil, Ana Olsavszky, Anna Lena Irkens, Verena Häfele, Bianca Dietsch, Niklas Straub, Sergij Goerdt and Cyrill Géraud |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1905844298 | ||
| 003 | DE-627 | ||
| 005 | 20241205181334.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241016s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers16020441 |2 doi | |
| 035 | |a (DE-627)1905844298 | ||
| 035 | |a (DE-599)KXP1905844298 | ||
| 035 | |a (OCoLC)1475315566 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wohlfeil, Sebastian A. |e VerfasserIn |0 (DE-588)1109821379 |0 (DE-627)864416334 |0 (DE-576)475626575 |4 aut | |
| 245 | 1 | 0 | |a Deficiency of Stabilin-1 in the context of hepatic melanoma metastasis |c Sebastian A. Wohlfeil, Ana Olsavszky, Anna Lena Irkens, Verena Häfele, Bianca Dietsch, Niklas Straub, Sergij Goerdt and Cyrill Géraud |
| 264 | 1 | |c 19 January 2024 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.10.2024 | ||
| 520 | |a Background: This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models. Methods: In Stabilin-1−/− mice (Stab1 KO), liver colonization of B16F10 luc2 and Wt31 melanoma was investigated. The numbers, morphology, and vascularization of hepatic metastases and the hepatic microenvironment were analyzed by immunofluorescence. Results: While hepatic metastasis of B16F10 luc2 or Wt31 melanoma was unaltered between Stab1 KO and wildtype (Ctrl) mice, metastases of B16F10 luc2 tended to be smaller in Stab1 KO. The endothelial differentiation of both types of liver metastases was similar in Stab1 KO and Ctrl. No differences in initial tumor cell adhesion and retention to the liver vasculature were detected in the B16F10 luc2 model. Analysis of the immune microenvironment revealed a trend towards higher levels of CD45+Gr-1+ cells in Stab1 KO as compared to Ctrl in the B16F10 luc2 model. Interestingly, significantly higher levels of POSTN were found in the matrix of hepatic metastases of Wt31, while liver metastases of B16F10 luc2 showed a trend towards increased deposition of RELN. Conclusions: Hepatic melanoma metastases show resistance to Stabilin-1 targeting approaches. This suggests that anti-Stab1 therapies should be considered with respect to the tumor entity or target organs. | ||
| 650 | 4 | |a cutaneous melanoma | |
| 650 | 4 | |a liver metastasis | |
| 650 | 4 | |a melanoma metastasis | |
| 650 | 4 | |a melanoma therapy | |
| 650 | 4 | |a Stablin-1 | |
| 700 | 1 | |a Olsavszky, Ana |d 1997- |e VerfasserIn |0 (DE-588)1221991515 |0 (DE-627)174041893X |4 aut | |
| 700 | 1 | |a Irkens, Anna Lena |d 1995- |e VerfasserIn |0 (DE-588)125132990X |0 (DE-627)1788859987 |4 aut | |
| 700 | 1 | |a Häfele, Verena |d 1990- |e VerfasserIn |0 (DE-588)1251325890 |0 (DE-627)1788804449 |4 aut | |
| 700 | 1 | |a Dietsch, Bianca |d 1986- |e VerfasserIn |0 (DE-588)1251327389 |0 (DE-627)1788807359 |4 aut | |
| 700 | 1 | |a Straub, Niklas |d 1997- |e VerfasserIn |0 (DE-588)1345109113 |0 (DE-627)1905871376 |4 aut | |
| 700 | 1 | |a Goerdt, Sergij |d 1959- |e VerfasserIn |0 (DE-588)1027602177 |0 (DE-627)729460010 |0 (DE-576)373451512 |4 aut | |
| 700 | 1 | |a Géraud, Cyrill |d 1982- |e VerfasserIn |0 (DE-588)137867808 |0 (DE-627)696132583 |0 (DE-576)304908932 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 16(2024), 2, Artikel-ID 441, Seite 1-14 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Deficiency of Stabilin-1 in the context of hepatic melanoma metastasis |
| 773 | 1 | 8 | |g volume:16 |g year:2024 |g number:2 |g elocationid:441 |g pages:1-14 |g extent:14 |a Deficiency of Stabilin-1 in the context of hepatic melanoma metastasis |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers16020441 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/16/2/441 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241016 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 137867808 |a Géraud, Cyrill |m 137867808:Géraud, Cyrill |d 60000 |d 61900 |e 60000PG137867808 |e 61900PG137867808 |k 0/60000/ |k 1/60000/61900/ |p 8 |y j | ||
| 998 | |g 1027602177 |a Goerdt, Sergij |m 1027602177:Goerdt, Sergij |d 60000 |d 61900 |e 60000PG1027602177 |e 61900PG1027602177 |k 0/60000/ |k 1/60000/61900/ |p 7 | ||
| 998 | |g 1345109113 |a Straub, Niklas |m 1345109113:Straub, Niklas |d 60000 |e 60000PS1345109113 |k 0/60000/ |p 6 | ||
| 998 | |g 1251327389 |a Dietsch, Bianca |m 1251327389:Dietsch, Bianca |d 60000 |d 61900 |e 60000PD1251327389 |e 61900PD1251327389 |k 0/60000/ |k 1/60000/61900/ |p 5 | ||
| 998 | |g 1251325890 |a Häfele, Verena |m 1251325890:Häfele, Verena |d 140000 |e 140000PH1251325890 |k 0/140000/ |p 4 | ||
| 998 | |g 125132990X |a Irkens, Anna Lena |m 125132990X:Irkens, Anna Lena |d 60000 |e 60000PI125132990X |k 0/60000/ |p 3 | ||
| 998 | |g 1221991515 |a Olsavszky, Ana |m 1221991515:Olsavszky, Ana |d 60000 |e 60000PO1221991515 |k 0/60000/ |p 2 | ||
| 998 | |g 1109821379 |a Wohlfeil, Sebastian A. |m 1109821379:Wohlfeil, Sebastian A. |d 60000 |d 61900 |e 60000PW1109821379 |e 61900PW1109821379 |k 0/60000/ |k 1/60000/61900/ |p 1 |x j | ||
| 999 | |a KXP-PPN1905844298 |e 4596319952 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"19 January 2024"}],"relHost":[{"disp":"Deficiency of Stabilin-1 in the context of hepatic melanoma metastasisCancers","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"text":"16(2024), 2, Artikel-ID 441, Seite 1-14","extent":"14","pages":"1-14","issue":"2","volume":"16","year":"2024"},"language":["eng"],"note":["Gesehen am 27.05.2020"],"pubHistory":["1.2009 -"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2527080-1"],"issn":["2072-6694"],"eki":["614095670"]},"title":[{"title":"Cancers","title_sort":"Cancers"}],"origin":[{"dateIssuedKey":"2009","publisherPlace":"Basel","publisher":"MDPI","dateIssuedDisp":"2009-"}],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"recId":"614095670"}],"physDesc":[{"extent":"14 S."}],"id":{"eki":["1905844298"],"doi":["10.3390/cancers16020441"]},"title":[{"title":"Deficiency of Stabilin-1 in the context of hepatic melanoma metastasis","title_sort":"Deficiency of Stabilin-1 in the context of hepatic melanoma metastasis"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 16.10.2024"],"recId":"1905844298","person":[{"display":"Wohlfeil, Sebastian A.","given":"Sebastian A.","family":"Wohlfeil","role":"aut"},{"family":"Olsavszky","role":"aut","given":"Ana","display":"Olsavszky, Ana"},{"given":"Anna Lena","display":"Irkens, Anna Lena","role":"aut","family":"Irkens"},{"given":"Verena","display":"Häfele, Verena","family":"Häfele","role":"aut"},{"family":"Dietsch","role":"aut","display":"Dietsch, Bianca","given":"Bianca"},{"display":"Straub, Niklas","given":"Niklas","role":"aut","family":"Straub"},{"given":"Sergij","display":"Goerdt, Sergij","role":"aut","family":"Goerdt"},{"role":"aut","family":"Géraud","given":"Cyrill","display":"Géraud, Cyrill"}],"name":{"displayForm":["Sebastian A. Wohlfeil, Ana Olsavszky, Anna Lena Irkens, Verena Häfele, Bianca Dietsch, Niklas Straub, Sergij Goerdt and Cyrill Géraud"]},"language":["eng"]} | ||
| SRT | |a WOHLFEILSEDEFICIENCY1920 | ||