Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis
CD4+ T-cell depletion in AIDS patients involves induction of apoptosis in human immunodeficiency virus (HIV)-infected and noninfected T cells. The HIV type 1 (HIV-1)-transactivating protein Tat enhances apoptosis and activation-induced cell death (AICD) of human T cells. This effect is mediated by t...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 1, 1996
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| In: |
Journal of virology
Year: 1996, Volume: 70, Issue: 9, Pages: 6502-6507 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/jvi.70.9.6502-6507.1996 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/jvi.70.9.6502-6507.1996 Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/10.1128/jvi.70.9.6502-6507.1996 
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| Author Notes: | Andreas Ehret, Michael O. Westendorp, Ingrid Herr, Klaus-Michael Debatin, Jonathan L. Heeney, Rainer Frank, Peter H. Krammer |
MARC
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| 245 | 1 | 0 | |a Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis |c Andreas Ehret, Michael O. Westendorp, Ingrid Herr, Klaus-Michael Debatin, Jonathan L. Heeney, Rainer Frank, Peter H. Krammer |
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| 520 | |a CD4+ T-cell depletion in AIDS patients involves induction of apoptosis in human immunodeficiency virus (HIV)-infected and noninfected T cells. The HIV type 1 (HIV-1)-transactivating protein Tat enhances apoptosis and activation-induced cell death (AICD) of human T cells. This effect is mediated by the CD95 (APO-1/Fas) receptor-CD95 ligand (CD95L) system and may be linked to the induction of oxidative stress by Tat. Here we show that HIV-1 Tat-induced oxidative stress is necessary for sensitized AICD in T cells caused by CD95L expression. Tat-enhanced apoptosis and CD95L expression in T cells are inhibited by neutralizing anti-Tat antibodies, antioxidants, and the Tat inhibitor Ro24-7429. Chimpanzees infected with HIV-1 show viral replication resembling early infection in humans but do not show T-cell depletion or progression towards AIDS. The cause for this discrepancy is unknown. Here we show that unlike Tat-treated T cells in humans, Tat-treated chimpanzee T cells do not show downregulation of manganese superoxide dismutase or signs of oxidative stress. Chimpanzee T cells are also resistant to Tat-enhanced apoptosis, AICD, and CD95L upregulation. | ||
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