Pulmonary function in patients with ANCA-associated vasculitis
Background and aim: Although pulmonary manifestations occur frequently in ANCA-associated vasculitis (AAV), empirical evidence of their impact on pulmonary function is scarce. This study analyzed pulmonary function test (PFT) data from a large cohort of patients with AVV. Results were correlated wit...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
Jun 28, 2024
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| In: |
Sarcoidosis, vasculitis and diffuse lung diseases
Year: 2024, Jahrgang: 41, Heft: 2 |
| DOI: | 10.36141/svdld.v41i2.15577 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.36141/svdld.v41i2.15577 Verlag, kostenfrei, Volltext: https://mattioli1885journals.com 
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| Verfasserangaben: | Johannes Dieterich, Bernhard Hellmich, Juliane Mahrhold, You-Shan Feng, Abdallah El Rai, Felix Nessyt, Ulrich Specks, Jürgen Hetzel, Christian Löffler |
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| 245 | 1 | 0 | |a Pulmonary function in patients with ANCA-associated vasculitis |c Johannes Dieterich, Bernhard Hellmich, Juliane Mahrhold, You-Shan Feng, Abdallah El Rai, Felix Nessyt, Ulrich Specks, Jürgen Hetzel, Christian Löffler |
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| 520 | |a Background and aim: Although pulmonary manifestations occur frequently in ANCA-associated vasculitis (AAV), empirical evidence of their impact on pulmonary function is scarce. This study analyzed pulmonary function test (PFT) data from a large cohort of patients with AVV. Results were correlated with findings from diagnostic imaging and disease activity. Methods: Data from AAV patients with PFTs performed between 2008 and 2018 were extracted retrospectively from the database of a tertiary vasculitis center. Demographic and disease characteristics, imaging data and follow-up results were assessed and compared to PFT results. Results: The final analysis encompassed 147 patients. The mean time between first PFT and follow-up was 7.0 ± 11.0 months. In Granulomatosis with Polyangiitis (GPA), forced expiratory vital capacity (FVCex, p<0.001), residual volume (RV, p<0.001) and the diffusion capacity of carbon oxide (TLCO, p=0.003) were significantly reduced compared to the reference value of 100% predicted. There was no significant difference between patients with or without pulmonary manifestations. In Microscopic Polyangiitis (MPA), reductions of FVCex (p<0.001), TLC (p=0.005), and TLCO (p=0.003) were observed. In Eosinophilic Granulomatosis with Polyangiitis (EGPA), total airway resistance (RAWtot, p=0.024) and RV (p=0.009) were significantly elevated and TLCO was reduced (p=0.014). Interstitial lung disease (ILD) is associated with a decline of FVCex (-15.7%, p=0.0028), TLC (-26.5%, p<0.001), RV (-38.9%, p=0.023) and TLCO (-29.1%, p=0.007). Significant differences were neither detected between first PFT and follow-up examination, nor between patients with active versus inactive disease. Conclusions: AAV patients presented with characteristic alterations in PFTs according to their respective pulmonary and/or airway manifestations. These results did not change over time and were independent from vasculitis activity. | ||
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| 700 | 1 | |a Mahrhold, Juliane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Feng, You-Shan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rai, Abdallah El |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nessyt, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Specks, Ulrich |e VerfasserIn |4 aut | |
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