Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021
Background: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2024
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| In: |
Contact dermatitis
Year: 2024, Volume: 90, Issue: 5, Pages: 470-478 |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/cod.14493 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/cod.14493 Verlag, kostenfrei, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.1111%2Fcod.14493&DestApp=DOI&SrcAppSID=EUW1ED0C50D8Hb6hoez360dlMJ5wL&SrcJTitle=CONTACT+DERMATITIS&DestDOIRegistrantName=Wiley+%28Blackwell+Publishing%29 
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| Author Notes: | Johannes Geier, Steffen Schubert, Juliane Rieker-Schwienbacher, Richard Brans, Elke Weisshaar, Birger Kraenke, Knut Brockow, Franziska Ruёff, Andreas Recke, Wolfgang Uter for the IVDK |
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| 245 | 1 | 0 | |a Declining frequency of sensitization to fragrance mixes I and II |b IVDK-data of the years 2012-2021 |c Johannes Geier, Steffen Schubert, Juliane Rieker-Schwienbacher, Richard Brans, Elke Weisshaar, Birger Kraenke, Knut Brockow, Franziska Ruёff, Andreas Recke, Wolfgang Uter for the IVDK |
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| 520 | |a Background: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are patch tested as screening mixtures in the baseline series.Objective: To describe the time trends of reaction frequencies to both FMs as well as to their components in FM-positive patients.Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2012-2021.Results: Positive reactions to FM I (FM II) declined from 9.1% (4.7%) in 2012 to 4.6% (3.0%) in 2021. Full breakdown tests were performed in 24% (FM I) and 31% (FM II), respectively, of the mix-positive patients. From this data, frequencies of sensitization to the 14 single fragrances of FM I and FM II were calculated. For the majority, a decline was noted from 2012/2013 to 2020/2021, for oakmoss absolute 1.9%-0.8% and for HICC 1.8%-0.9%.Conclusion: EU Commission Regulation 2017/1410 was an effective measure. However, our data have some limitations, possibly causing underestimation of sensitization frequencies to fragrances. | ||
| 650 | 4 | |a ALLERGY | |
| 650 | 4 | |a atranol | |
| 650 | 4 | |a BASE-LINE SERIES | |
| 650 | 4 | |a chloroatranol | |
| 650 | 4 | |a clinical epidemiology | |
| 650 | 4 | |a CONSTITUENTS | |
| 650 | 4 | |a contact allergy | |
| 650 | 4 | |a Evernia prunastri | |
| 650 | 4 | |a fragrance mix I | |
| 650 | 4 | |a fragrance mix II | |
| 650 | 4 | |a hydroxyisohexyl 3-cyclohexene carboxaldehyde | |
| 650 | 4 | |a patch testing | |
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