Therapeutic cerebral fluid puncture in patients with idiopathic intracranial hypertension: no short-term effect on neurocognitive function
Background: Idiopathic intracranial hypertension (IIH) is typically characterized by headaches and vision loss. However, neurocognitive deficits are also described. Our study aimed to test the influence of therapeutic lumbar puncture on the latter. Methods: A total of 15 patients with IIH were teste...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 August 2024
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| In: |
Brain Sciences
Year: 2024, Volume: 14, Issue: 9, Pages: 1-10 |
| ISSN: | 2076-3425 |
| DOI: | 10.3390/brainsci14090877 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/brainsci14090877 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2076-3425/14/9/877 
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| Author Notes: | Cem Thunstedt, Dilan Aydemir, Julian Conrad, Elisabeth Wlasich, Sandra V. Loosli, Florian Schöberl, Andreas Straube and Ozan E. Eren |
MARC
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| 245 | 1 | 0 | |a Therapeutic cerebral fluid puncture in patients with idiopathic intracranial hypertension |b no short-term effect on neurocognitive function |c Cem Thunstedt, Dilan Aydemir, Julian Conrad, Elisabeth Wlasich, Sandra V. Loosli, Florian Schöberl, Andreas Straube and Ozan E. Eren |
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| 520 | |a Background: Idiopathic intracranial hypertension (IIH) is typically characterized by headaches and vision loss. However, neurocognitive deficits are also described. Our study aimed to test the influence of therapeutic lumbar puncture on the latter. Methods: A total of 15 patients with IIH were tested with a battery of neurocognitive tests at baseline and after therapeutic lumbar drainage. Hereby, Logical Memory of the Wechsler Memory Scale—Revised Edition (WMS-R), the California Verbal Learning Test Short Version (CVLT), alertness, selective attention, and word fluency were used. Changes in cognitive functioning in the course of CSF pressure lowering were analysed and compared with age, sex, and education-matched healthy controls. Results: Before intervention, scores of Logical Memory, the RWT, and the HADS-D were significantly lower in IIH patients compared to matched controls. After short-term normalization of CSF pressure, the RWT improved significantly. Additionally, significant positive correlations were found between headache intensity and subjective impairment, as well as between BMI and CSF opening pressure. Conclusions: Our findings confirm lower performance in terms of long-term verbal memory and word fluency compared to controls, as well as depressive symptoms in IIH patients. Significant improvement after short-term normalization of intracranial pressure by means of CSF drainage was seen only for word fluency. This indicates that short-term normalization of CSF pressure is not sufficient to normalize observed neurocognitive deficits. | ||
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| 650 | 4 | |a idiopathic intracranial hypertension (IIH) | |
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| 700 | 1 | |a Loosli, Sandra V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schöberl, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Straube, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eren, Ozan E. |e VerfasserIn |4 aut | |
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