CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models
Relapse after anti-CD19 chimeric antigen receptor (CD19-CAR) occurs in a substantial proportion of patients with lymphoid malignancies. We assessed the potential benefits of co-administering CD20-targeting bispecific antibodies (CD20-BsAbs) with CD19-CAR T cells with the aim of enhancing immunothera...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 15, 2024
|
| In: |
Blood
Year: 2024, Jahrgang: 144, Heft: 7, Pages: 784-789 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood.2023022682 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2023022682
|
| Verfasserangaben: | Berit J. Brinkmann, Alessia Floerchinger, Christina Schniederjohann, Tobias Roider, Mariana Coelho, Norman Mack, Peter-Martin Bruch, Nora Liebers, Sarah Dötsch, Dirk H. Busch, Michael Schmitt, Frank Neumann, Philipp M. Roessner, Martina Seiffert, Sascha Dietrich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1906731713 | ||
| 003 | DE-627 | ||
| 005 | 20241220171136.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241024s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood.2023022682 |2 doi | |
| 035 | |a (DE-627)1906731713 | ||
| 035 | |a (DE-599)KXP1906731713 | ||
| 035 | |a (OCoLC)1475316841 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Brinkmann, Berit J. |d 1993- |e VerfasserIn |0 (DE-588)124968384X |0 (DE-627)1786214849 |4 aut | |
| 245 | 1 | 0 | |a CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models |c Berit J. Brinkmann, Alessia Floerchinger, Christina Schniederjohann, Tobias Roider, Mariana Coelho, Norman Mack, Peter-Martin Bruch, Nora Liebers, Sarah Dötsch, Dirk H. Busch, Michael Schmitt, Frank Neumann, Philipp M. Roessner, Martina Seiffert, Sascha Dietrich |
| 264 | 1 | |c August 15, 2024 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.10.2024 | ||
| 520 | |a Relapse after anti-CD19 chimeric antigen receptor (CD19-CAR) occurs in a substantial proportion of patients with lymphoid malignancies. We assessed the potential benefits of co-administering CD20-targeting bispecific antibodies (CD20-BsAbs) with CD19-CAR T cells with the aim of enhancing immunotherapeutic efficacy. Addition of CD20-BsAbs to cocultures of CD19-CARs and primary samples of B-cell malignancies, comprising malignant B cells and endogenous T cells, significantly improved killing of malignant cells and enhanced the expansion of both endogenous T cells and CD19-CAR T cells. In an immunocompetent mouse model of chronic lymphocytic leukemia, relapse after initial treatment response frequently occurred after CD19-CAR T-cell monotherapy. Additional treatment with CD20-BsAbs significantly enhanced the treatment response and led to improved eradication of malignant cells. Higher efficacy was accompanied by improved T-cell expansion with CD20-BsAb administration and led to longer survival with 80% of the mice being cured with no detectable malignant cell population within 8 weeks of therapy initiation. Collectively, our in vitro and in vivo data demonstrate enhanced therapeutic efficacy of CD19-CAR T cells when combined with CD20-BsAbs in B-cell malignancies. Activation and proliferation of both infused CAR T cells and endogenous T cells may contribute to improved disease control. | ||
| 700 | 1 | |a Floerchinger, Alessia |e VerfasserIn |0 (DE-588)1184301948 |0 (DE-627)1663459789 |4 aut | |
| 700 | 1 | |a Schniederjohann, Christina |e VerfasserIn |0 (DE-588)1345914792 |0 (DE-627)1906732507 |4 aut | |
| 700 | 1 | |a Roider, Tobias |d 1988- |e VerfasserIn |0 (DE-588)112919017X |0 (DE-627)883826232 |0 (DE-576)486252264 |4 aut | |
| 700 | 1 | |a Coelho, Mariana |d 1996- |e VerfasserIn |0 (DE-588)1301057509 |0 (DE-627)1858829372 |4 aut | |
| 700 | 1 | |a Mack, Norman |e VerfasserIn |0 (DE-588)1275458068 |0 (DE-627)1826932518 |4 aut | |
| 700 | 1 | |a Bruch, Peter-Martin |d 1993- |e VerfasserIn |0 (DE-588)1203140363 |0 (DE-627)168794198X |4 aut | |
| 700 | 1 | |a Liebers, Nora |d 1989- |e VerfasserIn |0 (DE-588)1123162875 |0 (DE-627)879999578 |0 (DE-576)481643850 |4 aut | |
| 700 | 1 | |a Dötsch, Sarah |e VerfasserIn |4 aut | |
| 700 | 1 | |a Busch, Dirk H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitt, Michael |d 1966- |e VerfasserIn |0 (DE-588)133177173 |0 (DE-627)538000600 |0 (DE-576)299672921 |4 aut | |
| 700 | 1 | |a Neumann, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rößner, Philipp M. |d 1991- |e VerfasserIn |0 (DE-588)1201434629 |0 (DE-627)1685140483 |4 aut | |
| 700 | 1 | |a Seiffert, Martina |d 1965- |e VerfasserIn |0 (DE-588)115760326 |0 (DE-627)691570736 |0 (DE-576)171620747 |4 aut | |
| 700 | 1 | |a Dietrich, Sascha |d 1979- |e VerfasserIn |0 (DE-588)136406300 |0 (DE-627)694354635 |0 (DE-576)301003408 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 144(2024), 7, Seite 784-789 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models |
| 773 | 1 | 8 | |g volume:144 |g year:2024 |g number:7 |g pages:784-789 |g extent:6 |a CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models |
| 856 | 4 | 0 | |u https://doi.org/10.1182/blood.2023022682 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241024 | ||
| 994 | |a 2024 | ||
| 998 | |g 136406300 |a Dietrich, Sascha |m 136406300:Dietrich, Sascha |d 910000 |d 910100 |d 50000 |e 910000PD136406300 |e 910100PD136406300 |e 50000PD136406300 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 15 |y j | ||
| 998 | |g 115760326 |a Seiffert, Martina |m 115760326:Seiffert, Martina |p 14 | ||
| 998 | |g 1201434629 |a Rößner, Philipp M. |m 1201434629:Rößner, Philipp M. |d 50000 |e 50000PR1201434629 |k 0/50000/ |p 13 | ||
| 998 | |g 133177173 |a Schmitt, Michael |m 133177173:Schmitt, Michael |d 910000 |d 910100 |e 910000PS133177173 |e 910100PS133177173 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1123162875 |a Liebers, Nora |m 1123162875:Liebers, Nora |d 50000 |e 50000PL1123162875 |k 0/50000/ |p 8 | ||
| 998 | |g 1203140363 |a Bruch, Peter-Martin |m 1203140363:Bruch, Peter-Martin |d 50000 |e 50000PB1203140363 |k 0/50000/ |p 7 | ||
| 998 | |g 1275458068 |a Mack, Norman |m 1275458068:Mack, Norman |p 6 | ||
| 998 | |g 112919017X |a Roider, Tobias |m 112919017X:Roider, Tobias |d 910000 |d 910100 |e 910000PR112919017X |e 910100PR112919017X |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1345914792 |a Schniederjohann, Christina |m 1345914792:Schniederjohann, Christina |d 910000 |d 910100 |e 910000PS1345914792 |e 910100PS1345914792 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 999 | |a KXP-PPN1906731713 |e 4602065910 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 24.10.2024"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"role":"isb","display":"American Society of Hematology"}],"title":[{"title_sort":"Blood","subtitle":"journal of the American Society of Hematology","title":"Blood"}],"disp":"CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo modelsBlood","recId":"266886647","origin":[{"dateIssuedDisp":"1946-","publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946","publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif."}],"id":{"issn":["1528-0020"],"zdb":["1468538-3"],"eki":["266886647"]},"pubHistory":["1.1946 -"],"titleAlt":[{"title":"Blood online"}],"note":["Gesehen am 21.04.2023"],"part":{"issue":"7","year":"2024","pages":"784-789","volume":"144","extent":"6","text":"144(2024), 7, Seite 784-789"}}],"physDesc":[{"extent":"6 S."}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models","title":"CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models"}],"person":[{"family":"Brinkmann","given":"Berit J.","role":"aut","display":"Brinkmann, Berit J."},{"family":"Floerchinger","role":"aut","given":"Alessia","display":"Floerchinger, Alessia"},{"display":"Schniederjohann, Christina","family":"Schniederjohann","given":"Christina","role":"aut"},{"given":"Tobias","role":"aut","family":"Roider","display":"Roider, Tobias"},{"family":"Coelho","given":"Mariana","role":"aut","display":"Coelho, Mariana"},{"display":"Mack, Norman","family":"Mack","role":"aut","given":"Norman"},{"role":"aut","given":"Peter-Martin","family":"Bruch","display":"Bruch, Peter-Martin"},{"display":"Liebers, Nora","role":"aut","given":"Nora","family":"Liebers"},{"family":"Dötsch","given":"Sarah","role":"aut","display":"Dötsch, Sarah"},{"display":"Busch, Dirk H.","family":"Busch","role":"aut","given":"Dirk H."},{"family":"Schmitt","given":"Michael","role":"aut","display":"Schmitt, Michael"},{"display":"Neumann, Frank","given":"Frank","role":"aut","family":"Neumann"},{"display":"Rößner, Philipp M.","role":"aut","given":"Philipp M.","family":"Rößner"},{"display":"Seiffert, Martina","given":"Martina","role":"aut","family":"Seiffert"},{"display":"Dietrich, Sascha","role":"aut","given":"Sascha","family":"Dietrich"}],"recId":"1906731713","name":{"displayForm":["Berit J. Brinkmann, Alessia Floerchinger, Christina Schniederjohann, Tobias Roider, Mariana Coelho, Norman Mack, Peter-Martin Bruch, Nora Liebers, Sarah Dötsch, Dirk H. Busch, Michael Schmitt, Frank Neumann, Philipp M. Roessner, Martina Seiffert, Sascha Dietrich"]},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"August 15, 2024"}],"id":{"eki":["1906731713"],"doi":["10.1182/blood.2023022682"]}} | ||
| SRT | |a BRINKMANNBCD20BISPEC1520 | ||