Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinoma
Background: The anti-neoplastic activity of metformin is a subject of current debate. Preclinical data have suggested that metformin enhances PD-L1 anti-tumor effects in various cancer entities by decreasing insulin levels and inducing energetic stress. However, its impact on PD-L1 expression remain...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 September 2024
|
| In: |
Journal of Clinical Medicine
Year: 2024, Jahrgang: 13, Heft: 18, Pages: 1-10 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm13185632 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm13185632 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/13/18/5632 
|
| Verfasserangaben: | Andreas Mamilos, Lina Winter, Alexander Lein, Steffen Spoerl, Nils Ludwig, Tobias Ettl, Julian Künzel, Torsten Reichert, Gerrit Spanier and Christoph Brochhausen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1907016236 | ||
| 003 | DE-627 | ||
| 005 | 20241205183303.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241028s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/jcm13185632 |2 doi | |
| 035 | |a (DE-627)1907016236 | ||
| 035 | |a (DE-599)KXP1907016236 | ||
| 035 | |a (OCoLC)1475324370 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mamilos, Andreas |d 1986- |e VerfasserIn |0 (DE-588)1161492232 |0 (DE-627)1024791718 |0 (DE-576)506582620 |4 aut | |
| 245 | 1 | 0 | |a Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinoma |c Andreas Mamilos, Lina Winter, Alexander Lein, Steffen Spoerl, Nils Ludwig, Tobias Ettl, Julian Künzel, Torsten Reichert, Gerrit Spanier and Christoph Brochhausen |
| 264 | 1 | |c 23 September 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.10.2024 | ||
| 520 | |a Background: The anti-neoplastic activity of metformin is a subject of current debate. Preclinical data have suggested that metformin enhances PD-L1 anti-tumor effects in various cancer entities by decreasing insulin levels and inducing energetic stress. However, its impact on PD-L1 expression remains unclear in a clinical setting. Therefore, we aim to investigate the impact of metformin treatment in type 2 diabetes mellitus (DM) patients on PD-L1 expression in patients with oral squamous cell carcinoma (OSCC). Methods: We performed a retrospective analysis of patients with DM and OSCC treated at our tertiary referral center over a period of 12 years. The tumor proportion score (TPS), immune cell score (IC), and combined positive score (CPS) were used to quantify PD-L1 expression. PD-L1 expression of patients receiving metformin was compared to a control group without metformin prescription. Results: A total of 68 patients diagnosed with OSCC and DM were analyzed, with 24 receiving and 44 not receiving metformin therapy. No statistically significant differences were identified between the metformin and non-metformin groups for any of the scores (TPS: p = 0.818; IC: p = 0.748; CPS: p = 0.387). Conclusions: In contrast to previous studies, we could not find significant differences in PD-L1 expression between patients with and without metformin intake. Further research needs to shed light on the exact mechanism of metformin in different tumor entities. A comprehensive understanding of metformin’s role in cancer therapy could provide valuable insights for potential use of metformin as an adjuvant treatment to immune checkpoint therapy. | ||
| 650 | 4 | |a diabetes | |
| 650 | 4 | |a immunohistochemistry | |
| 650 | 4 | |a metformin | |
| 650 | 4 | |a oral squamous cell carcinoma | |
| 650 | 4 | |a OSCC | |
| 650 | 4 | |a PD-L1 | |
| 700 | 1 | |a Winter, Lina |e VerfasserIn |0 (DE-588)1324478454 |0 (DE-627)1884337805 |4 aut | |
| 700 | 1 | |a Lein, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spoerl, Steffen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ludwig, Nils |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ettl, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Künzel, Julian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reichert, Torsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spanier, Gerrit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brochhausen, Christoph |d 1969- |e VerfasserIn |0 (DE-588)123220963 |0 (DE-627)082421226 |0 (DE-576)293610843 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Clinical Medicine |d Basel : MDPI, 2012 |g 13(2024), 18, Artikel-ID 5632, Seite 1-10 |h Online-Ressource |w (DE-627)718632478 |w (DE-600)2662592-1 |w (DE-576)365782718 |x 2077-0383 |7 nnas |a Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinoma |
| 773 | 1 | 8 | |g volume:13 |g year:2024 |g number:18 |g elocationid:5632 |g pages:1-10 |g extent:10 |a Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.3390/jcm13185632 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2077-0383/13/18/5632 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241028 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 123220963 |a Brochhausen, Christoph |m 123220963:Brochhausen, Christoph |d 60000 |d 63400 |e 60000PB123220963 |e 63400PB123220963 |k 0/60000/ |k 1/60000/63400/ |p 10 |y j | ||
| 998 | |g 1324478454 |a Winter, Lina |m 1324478454:Winter, Lina |d 60000 |d 63400 |e 60000PW1324478454 |e 63400PW1324478454 |k 0/60000/ |k 1/60000/63400/ |p 2 | ||
| 999 | |a KXP-PPN1907016236 |e 4603563574 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"10 S."}],"relHost":[{"title":[{"title":"Journal of Clinical Medicine","title_sort":"Journal of Clinical Medicine","subtitle":"open access journal"}],"pubHistory":["1.2012 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedDisp":"2012-","publisher":"MDPI","publisherPlace":"Basel","dateIssuedKey":"2012"}],"note":["Gesehen am 12.06.20"],"id":{"eki":["718632478"],"issn":["2077-0383"],"zdb":["2662592-1"]},"recId":"718632478","physDesc":[{"extent":"Online-Ressource"}],"disp":"Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinomaJournal of Clinical Medicine","part":{"text":"13(2024), 18, Artikel-ID 5632, Seite 1-10","issue":"18","year":"2024","extent":"10","pages":"1-10","volume":"13"},"language":["eng"]}],"name":{"displayForm":["Andreas Mamilos, Lina Winter, Alexander Lein, Steffen Spoerl, Nils Ludwig, Tobias Ettl, Julian Künzel, Torsten Reichert, Gerrit Spanier and Christoph Brochhausen"]},"recId":"1907016236","id":{"eki":["1907016236"],"doi":["10.3390/jcm13185632"]},"note":["Gesehen am 28.10.2024"],"origin":[{"dateIssuedDisp":"23 September 2024","dateIssuedKey":"2024"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","family":"Mamilos","given":"Andreas","display":"Mamilos, Andreas"},{"display":"Winter, Lina","family":"Winter","given":"Lina","role":"aut"},{"role":"aut","given":"Alexander","family":"Lein","display":"Lein, Alexander"},{"role":"aut","display":"Spoerl, Steffen","family":"Spoerl","given":"Steffen"},{"family":"Ludwig","given":"Nils","display":"Ludwig, Nils","role":"aut"},{"display":"Ettl, Tobias","family":"Ettl","given":"Tobias","role":"aut"},{"given":"Julian","family":"Künzel","display":"Künzel, Julian","role":"aut"},{"role":"aut","family":"Reichert","given":"Torsten","display":"Reichert, Torsten"},{"role":"aut","family":"Spanier","given":"Gerrit","display":"Spanier, Gerrit"},{"role":"aut","display":"Brochhausen, Christoph","family":"Brochhausen","given":"Christoph"}],"title":[{"title_sort":"Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinoma","title":"Metformin treatment is not associated with altered PD-L1 expression in diabetic patients with oral squamous cell carcinoma"}]} | ||
| SRT | |a MAMILOSANDMETFORMINT2320 | ||