Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite
In cystic fibrosis (CF), Pseudomonas aeruginosa infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely un...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
9 March 2024
|
| In: |
Microbiological research
Year: 2024, Jahrgang: 283, Pages: 127680-1-127680-11 |
| ISSN: | 1618-0623 |
| DOI: | 10.1016/j.micres.2024.127680 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.micres.2024.127680 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0944501324000818 
|
| Verfasserangaben: | Andrew Tony-Odigie, Alexander H. Dalpke, Sébastien Boutin, Buqing Yi |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1907028471 | ||
| 003 | DE-627 | ||
| 005 | 20241205183328.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241028s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.micres.2024.127680 |2 doi | |
| 035 | |a (DE-627)1907028471 | ||
| 035 | |a (DE-599)KXP1907028471 | ||
| 035 | |a (OCoLC)1475317168 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tony-Odigie, Andrew |e VerfasserIn |0 (DE-588)125363176X |0 (DE-627)1795984503 |4 aut | |
| 245 | 1 | 0 | |a Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite |c Andrew Tony-Odigie, Alexander H. Dalpke, Sébastien Boutin, Buqing Yi |
| 264 | 1 | |c 9 March 2024 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.10.2024 | ||
| 520 | |a In cystic fibrosis (CF), Pseudomonas aeruginosa infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely unknown. In this study, we aimed to identify airway commensal bacteria that may inhibit the growth of P. aeruginosa. Through a screening study with more than 80 CF commensal strains across 21 species, more than 30 commensal strains from various species have been identified to be able to inhibit the growth of P. aeruginosa. The underlying mechanisms were investigated via genomic, metabolic and functional analysis, revealing that the inhibitory commensals may affect the growth of P. aeruginosa by releasing a large amount of acetic acid. The data provide information about the distinct roles of airway commensals and provide insights into novel strategies for controlling airway infections. | ||
| 650 | 4 | |a Airway microbiome | |
| 650 | 4 | |a Commensal-Pathogen interaction | |
| 650 | 4 | |a Cystic fibrosis | |
| 650 | 4 | |a Growth inhibition | |
| 650 | 4 | |a Infection control | |
| 650 | 4 | |a Respiratory infection | |
| 700 | 1 | |a Dalpke, Alexander |d 1971- |e VerfasserIn |0 (DE-588)123821878 |0 (DE-627)706438523 |0 (DE-576)293894272 |4 aut | |
| 700 | 1 | |a Boutin, Sébastien |e VerfasserIn |0 (DE-588)112876217X |0 (DE-627)883204479 |0 (DE-576)486061353 |4 aut | |
| 700 | 1 | |a Yi, Buqing |d 1977- |e VerfasserIn |0 (DE-588)139815015 |0 (DE-627)613785274 |0 (DE-576)312537794 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Microbiological research |d Jena : Urban & Fischer, 1994 |g 283(2024), Artikel-ID 127680, Seite 127680-1-127680-11 |h Online-Ressource |w (DE-627)331504820 |w (DE-600)2051526-1 |w (DE-576)094481032 |x 1618-0623 |7 nnas |a Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite |
| 773 | 1 | 8 | |g volume:283 |g year:2024 |g elocationid:127680 |g pages:127680-1-127680-11 |g extent:11 |a Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.micres.2024.127680 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0944501324000818 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241028 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 112876217X |a Boutin, Sébastien |m 112876217X:Boutin, Sébastien |d 50000 |e 50000PB112876217X |k 0/50000/ |p 3 | ||
| 998 | |g 123821878 |a Dalpke, Alexander |m 123821878:Dalpke, Alexander |d 910000 |d 911700 |e 910000PD123821878 |e 911700PD123821878 |k 0/910000/ |k 1/910000/911700/ |p 2 | ||
| 998 | |g 125363176X |a Tony-Odigie, Andrew |m 125363176X:Tony-Odigie, Andrew |d 910000 |d 911700 |e 910000PT125363176X |e 911700PT125363176X |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1907028471 |e 4603604661 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1907028471"],"doi":["10.1016/j.micres.2024.127680"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 16.05.23"],"origin":[{"dateIssuedDisp":"1994-","dateIssuedKey":"1994","publisher":"Urban & Fischer","publisherPlace":"Jena"}],"id":{"eki":["331504820"],"issn":["1618-0623"],"zdb":["2051526-1"]},"recId":"331504820","title":[{"title":"Microbiological research","subtitle":"formerly Zentralblatt für Mikrobiologie","title_sort":"Microbiological research"}],"disp":"Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metaboliteMicrobiological research","part":{"extent":"11","year":"2024","volume":"283","pages":"127680-1-127680-11","text":"283(2024), Artikel-ID 127680, Seite 127680-1-127680-11"},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["149.1994 - 169.2014; Vol. 170.2015 -"]}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"9 March 2024"}],"note":["Gesehen am 28.10.2024"],"person":[{"family":"Tony-Odigie","roleDisplay":"VerfasserIn","given":"Andrew","display":"Tony-Odigie, Andrew","role":"aut"},{"display":"Dalpke, Alexander","role":"aut","given":"Alexander","roleDisplay":"VerfasserIn","family":"Dalpke"},{"family":"Boutin","roleDisplay":"VerfasserIn","given":"Sébastien","role":"aut","display":"Boutin, Sébastien"},{"display":"Yi, Buqing","role":"aut","given":"Buqing","family":"Yi","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"11 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Andrew Tony-Odigie, Alexander H. Dalpke, Sébastien Boutin, Buqing Yi"]},"title":[{"title_sort":"Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite","title":"Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite"}],"recId":"1907028471"} | ||
| SRT | |a TONYODIGIEAIRWAYCOMM9202 | ||