Functional status and quality of life in older patients with advanced esophageal squamous cell cancer receiving second-line nivolumab ± ipilimumab therapy: a post hoc analysis of the phase 2, multicenter RAMONA study
Introduction - The phase 2 RAMONA study demonstrated that second-line nivolumab ± ipilimumab immunotherapy was feasible and effective in older patients with advanced esophageal squamous cell cancer (ESCC). Here, we presented results from functional status (FS) and quality-of-life (QoL) analyses. - M...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2024
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| In: |
Journal of geriatric oncology
Year: 2024, Volume: 15, Issue: 7, Pages: 1-8 |
| ISSN: | 1879-4076 |
| DOI: | 10.1016/j.jgo.2024.101838 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jgo.2024.101838 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S187940682400136X 
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| Author Notes: | Moying Li, Nadja M. Meindl-Beinker, Martin Maenz, Johannes Betge, Nadine Schulte, Tianzuo Zhan, Ralf-Dieter Hofheinz, Arndt Vogel, Stefan Angermeier, Claus Bolling, Maike de Wit, Ralf Jakobs, Meinolf Karthaus, Gertraud Stocker, Peter Thuss-Patience, Tobias Leidig, Hans Bauer, Matthias P. Ebert, Nicolai Haertel |
MARC
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| 245 | 1 | 0 | |a Functional status and quality of life in older patients with advanced esophageal squamous cell cancer receiving second-line nivolumab ± ipilimumab therapy |b a post hoc analysis of the phase 2, multicenter RAMONA study |c Moying Li, Nadja M. Meindl-Beinker, Martin Maenz, Johannes Betge, Nadine Schulte, Tianzuo Zhan, Ralf-Dieter Hofheinz, Arndt Vogel, Stefan Angermeier, Claus Bolling, Maike de Wit, Ralf Jakobs, Meinolf Karthaus, Gertraud Stocker, Peter Thuss-Patience, Tobias Leidig, Hans Bauer, Matthias P. Ebert, Nicolai Haertel |
| 246 | 3 | 3 | |a Functional status and quality of life in older patients with advanced esophageal squamous cell cancer receiving second-line nivolumab plus-minus ipilimumab therapy |
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| 520 | |a Introduction - The phase 2 RAMONA study demonstrated that second-line nivolumab ± ipilimumab immunotherapy was feasible and effective in older patients with advanced esophageal squamous cell cancer (ESCC). Here, we presented results from functional status (FS) and quality-of-life (QoL) analyses. - Materials and Methods - Patients aged ≥65 years with advanced ESCC and disease progression following first-line therapy were enrolled for study treatment with nivolumab ± ipilimumab. Geriatric assessments (GA) consisting of G8 and GoGo/SlowGo evaluation, and quality of life (QoL) assessments with EORTC QLQ-C30 questionnaires were conducted at baseline and during the treatment. A post hoc analysis was performed to compare therapy efficacy, toxicity, and QoL between age groups (≥70 years vs. <70 years) and functionality groups (G8 > 14 vs. ≤14 and GoGo vs. SlowGo). - Results - In 66 treated patients with a median age of 70.5 years, older patients had non-inferior overall survival and tumor response compared to younger patients, with no increased treatment-related adverse events. Fitter patients (G8 > 14, GoGo) had a clinically, yet not statistically significant, survival advantage than less fit patients (G8 ≤ 14, SlowGo) patients. Moreover, FS by G8 and GoGo/SlowGo significantly correlated with QoL. Overall, QoL was impaired at baseline but remained stable in all scales over the course of immunotherapy. - Discussion - The administration of nivolumab ± ipilimumab second-line immunotherapy in older patients with ESCC did not show age-dependent effects and maintained QoL. GA could identify functional deficits and limitations of QoL and should be implemented in the context of immunotherapy. ClinicalTrials.gov: NCT03416244. | ||
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| 650 | 4 | |a Geriatric assessment | |
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| 650 | 4 | |a Quality of life | |
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