Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling
Pathological cardiac remodeling predisposes individuals to developing heart failure. Here, we investigated two co-regulated long non-coding RNAs (lncRNAs), termed Gadlor1 and Gadlor2, which are upregulated in failing hearts of patients and mice. Cardiac overexpression of Gadlor1 and Gadlor2 aggravat...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 September 2024
|
| In: |
Molecular therapy. Nucleic Acids
Year: 2024, Jahrgang: 35, Heft: 3, Pages: 1-22 |
| ISSN: | 2162-2531 |
| DOI: | 10.1016/j.omtn.2024.102306 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.omtn.2024.102306 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2162253124001938 
|
| Verfasserangaben: | Merve Keles, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Koch, Stefanie Uhlig, Santosh Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, Abel Martin-Garrido, Johann Bauersachs, Derk Frank, Norbert Frey, Karen Bieback, Julio Cordero, Gergana Dobreva, Thomas Wieland, and Joerg Heineke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1907199829 | ||
| 003 | DE-627 | ||
| 005 | 20241205183803.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241030s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.omtn.2024.102306 |2 doi | |
| 035 | |a (DE-627)1907199829 | ||
| 035 | |a (DE-599)KXP1907199829 | ||
| 035 | |a (OCoLC)1475637012 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Keles, Merve |d 1993- |e VerfasserIn |0 (DE-588)1282082817 |0 (DE-627)1837680647 |4 aut | |
| 245 | 1 | 0 | |a Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling |c Merve Keles, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Koch, Stefanie Uhlig, Santosh Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, Abel Martin-Garrido, Johann Bauersachs, Derk Frank, Norbert Frey, Karen Bieback, Julio Cordero, Gergana Dobreva, Thomas Wieland, and Joerg Heineke |
| 264 | 1 | |c 10 September 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 22 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 15. August 2024, Artikelversion: 30 August 2024 | ||
| 500 | |a Gesehen am 30.10.2024 | ||
| 520 | |a Pathological cardiac remodeling predisposes individuals to developing heart failure. Here, we investigated two co-regulated long non-coding RNAs (lncRNAs), termed Gadlor1 and Gadlor2, which are upregulated in failing hearts of patients and mice. Cardiac overexpression of Gadlor1 and Gadlor2 aggravated myocardial dysfunction and enhanced hypertrophic and fibrotic remodeling in mice exposed to pressure overload. Compound Gadlor1/2 knockout (KO) mice showed markedly reduced myocardial hypertrophy, fibrosis, and dysfunction, while exhibiting increased angiogenesis during short and prolonged periods of pressure overload. Paradoxically, Gadlor1/2 KO mice suffered from sudden death during prolonged overload, possibly due to cardiac arrhythmia. Gadlor1 and Gadlor2, which are mainly expressed in endothelial cells (ECs) in the heart, where they inhibit pro-angiogenic gene expression, are strongly secreted within extracellular vesicles (EVs). These EVs transfer Gadlor lncRNAs to cardiomyocytes, where they bind and activate calmodulin-dependent kinase II, and impact pro-hypertrophic gene expression and calcium homeostasis. Therefore, we reveal a crucial lncRNA-based mechanism of EC-cardiomyocyte crosstalk during heart failure, which could be specifically modified in the future for therapeutic purposes. | ||
| 650 | 4 | |a calcium/calmodulin-dependent protein kinase type II | |
| 650 | 4 | |a cardiac angiogenesis | |
| 650 | 4 | |a extracellular vesicles | |
| 650 | 4 | |a heart failure | |
| 650 | 4 | |a hypertrophy | |
| 650 | 4 | |a MT:Non-coding RNAs | |
| 700 | 1 | |a Grein, Steve |d 1993- |e VerfasserIn |0 (DE-588)1254654364 |0 (DE-627)1797324519 |4 aut | |
| 700 | 1 | |a Froese, Natali |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wirth, Dagmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trogisch, Felix |d 1988- |e VerfasserIn |0 (DE-588)1153485788 |0 (DE-627)1014907896 |0 (DE-576)500255210 |4 aut | |
| 700 | 1 | |a Wardman, Rhys |e VerfasserIn |0 (DE-588)131132464X |0 (DE-627)1871299470 |4 aut | |
| 700 | 1 | |a Hemanna, Shruthi |d 1989- |e VerfasserIn |0 (DE-588)1193206871 |0 (DE-627)1671865901 |4 aut | |
| 700 | 1 | |a Weinzierl, Nina |d 1971- |e VerfasserIn |0 (DE-588)116616084X |0 (DE-627)1030096899 |0 (DE-576)510648843 |4 aut | |
| 700 | 1 | |a Reiners-Koch, Philipp-Sebastian |d 1982- |e VerfasserIn |0 (DE-588)1017371660 |0 (DE-627)676385745 |0 (DE-576)353602825 |4 aut | |
| 700 | 1 | |a Uhlig, Stefanie |d 1987- |e VerfasserIn |0 (DE-588)1163402206 |0 (DE-627)1027768164 |0 (DE-576)507962729 |4 aut | |
| 700 | 1 | |a Lomada, Santosh K. |d 1988- |e VerfasserIn |0 (DE-588)1222202697 |0 (DE-627)1741214750 |4 aut | |
| 700 | 1 | |a Dittrich, Gesine M. |e VerfasserIn |0 (DE-588)1292710799 |0 (DE-627)1848976550 |4 aut | |
| 700 | 1 | |a Szaroszyk, Malgorzata |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haustein, Ricarda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hegermann, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martin Garrido, Abel |d 1978- |e VerfasserIn |0 (DE-588)1292809418 |0 (DE-627)1849791023 |4 aut | |
| 700 | 1 | |a Bauersachs, Johann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Frank, Derk |d 1976- |e VerfasserIn |0 (DE-588)129342904 |0 (DE-627)394257413 |0 (DE-576)297610252 |4 aut | |
| 700 | 1 | |a Frey, Norbert |e VerfasserIn |0 (DE-588)141244976 |0 (DE-627)625824075 |0 (DE-576)322969514 |4 aut | |
| 700 | 1 | |a Bieback, Karen |d 1972- |e VerfasserIn |0 (DE-588)124509991 |0 (DE-627)376254653 |0 (DE-576)294206604 |4 aut | |
| 700 | 1 | |a Cordero, Julio |d 1979- |e VerfasserIn |0 (DE-588)1160051755 |0 (DE-627)102314736X |0 (DE-576)505467429 |4 aut | |
| 700 | 1 | |a Dobreva, Gergana |d 1977- |e VerfasserIn |0 (DE-588)128752343 |0 (DE-627)379128888 |0 (DE-576)297314491 |4 aut | |
| 700 | 1 | |a Wieland, Thomas |d 1960-2025 |e VerfasserIn |0 (DE-588)1033445908 |0 (DE-627)741233215 |0 (DE-576)381043339 |4 aut | |
| 700 | 1 | |a Heineke, Jörg |d 1974- |e VerfasserIn |0 (DE-588)122672321 |0 (DE-627)082082715 |0 (DE-576)293374805 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular therapy. Nucleic Acids |d New York, NY : Nature Publ. Group, 2012 |g 35(2024), 3, Artikel-ID 102306, Seite 1-22 |h Online-Ressource |w (DE-627)718632702 |w (DE-600)2662631-7 |w (DE-576)365782785 |x 2162-2531 |7 nnas |a Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling |
| 773 | 1 | 8 | |g volume:35 |g year:2024 |g number:3 |g elocationid:102306 |g pages:1-22 |g extent:22 |a Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.omtn.2024.102306 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2162253124001938 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241030 | ||
| 992 | |a 20241030 | ||
| 993 | |a Article | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 994 | |a 2024 | ||
| 998 | |g 122672321 |a Heineke, Jörg |m 122672321:Heineke, Jörg |d 60000 |d 65000 |e 60000PH122672321 |e 65000PH122672321 |k 0/60000/ |k 1/60000/65000/ |p 24 |y j | ||
| 998 | |g 1033445908 |a Wieland, Thomas |m 1033445908:Wieland, Thomas |d 60000 |d 65000 |e 60000PW1033445908 |e 65000PW1033445908 |k 0/60000/ |k 1/60000/65000/ |p 23 | ||
| 998 | |g 128752343 |a Dobreva, Gergana |m 128752343:Dobreva, Gergana |d 60000 |d 65000 |e 60000PD128752343 |e 65000PD128752343 |k 0/60000/ |k 1/60000/65000/ |p 22 | ||
| 998 | |g 1160051755 |a Cordero, Julio |m 1160051755:Cordero, Julio |d 60000 |d 65000 |e 60000PC1160051755 |e 65000PC1160051755 |k 0/60000/ |k 1/60000/65000/ |p 21 | ||
| 998 | |g 124509991 |a Bieback, Karen |m 124509991:Bieback, Karen |d 60000 |d 63500 |d 60000 |e 60000PB124509991 |e 63500PB124509991 |e 60000PB124509991 |k 0/60000/ |k 1/60000/63500/ |k 0/60000/ |p 20 | ||
| 998 | |g 141244976 |a Frey, Norbert |m 141244976:Frey, Norbert |d 910000 |d 910100 |e 910000PF141244976 |e 910100PF141244976 |k 0/910000/ |k 1/910000/910100/ |p 19 | ||
| 998 | |g 129342904 |a Frank, Derk |m 129342904:Frank, Derk |d 50000 |e 50000PF129342904 |k 0/50000/ |p 18 | ||
| 998 | |g 1292809418 |a Martin Garrido, Abel |m 1292809418:Martin Garrido, Abel |d 60000 |d 65000 |e 60000PM1292809418 |e 65000PM1292809418 |k 0/60000/ |k 1/60000/65000/ |p 16 | ||
| 998 | |g 1292710799 |a Dittrich, Gesine M. |m 1292710799:Dittrich, Gesine M. |p 12 | ||
| 998 | |g 1222202697 |a Lomada, Santosh K. |m 1222202697:Lomada, Santosh K. |d 60000 |d 65000 |e 60000PL1222202697 |e 65000PL1222202697 |k 0/60000/ |k 1/60000/65000/ |p 11 | ||
| 998 | |g 1163402206 |a Uhlig, Stefanie |m 1163402206:Uhlig, Stefanie |d 60000 |d 63500 |e 60000PU1163402206 |e 63500PU1163402206 |k 0/60000/ |k 1/60000/63500/ |p 10 | ||
| 998 | |g 1017371660 |a Reiners-Koch, Philipp-Sebastian |m 1017371660:Reiners-Koch, Philipp-Sebastian |d 60000 |d 61900 |d 60000 |e 60000PR1017371660 |e 61900PR1017371660 |e 60000PR1017371660 |k 0/60000/ |k 1/60000/61900/ |k 0/60000/ |p 9 | ||
| 998 | |g 116616084X |a Weinzierl, Nina |m 116616084X:Weinzierl, Nina |d 60000 |d 65000 |e 60000PW116616084X |e 65000PW116616084X |k 0/60000/ |k 1/60000/65000/ |p 8 | ||
| 998 | |g 1193206871 |a Hemanna, Shruthi |m 1193206871:Hemanna, Shruthi |d 60000 |d 65000 |e 60000PH1193206871 |e 65000PH1193206871 |k 0/60000/ |k 1/60000/65000/ |p 7 | ||
| 998 | |g 131132464X |a Wardman, Rhys |m 131132464X:Wardman, Rhys |d 60000 |d 65000 |e 60000PW131132464X |e 65000PW131132464X |k 0/60000/ |k 1/60000/65000/ |p 6 | ||
| 998 | |g 1153485788 |a Trogisch, Felix |m 1153485788:Trogisch, Felix |d 60000 |d 65000 |e 60000PT1153485788 |e 65000PT1153485788 |k 0/60000/ |k 1/60000/65000/ |p 5 | ||
| 998 | |g 1254654364 |a Grein, Steve |m 1254654364:Grein, Steve |p 2 | ||
| 998 | |g 1282082817 |a Keles, Merve |m 1282082817:Keles, Merve |p 1 |x j | ||
| 999 | |a KXP-PPN1907199829 |e 4608462148 | ||
| 999 | |a KXP-PPN1907199829 |e 4608455710 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online verfügbar: 15. August 2024, Artikelversion: 30 August 2024","Gesehen am 30.10.2024"],"recId":"1907199829","language":["eng"],"origin":[{"dateIssuedDisp":"10 September 2024","dateIssuedKey":"2024"}],"name":{"displayForm":["Merve Keles, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Koch, Stefanie Uhlig, Santosh Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, Abel Martin-Garrido, Johann Bauersachs, Derk Frank, Norbert Frey, Karen Bieback, Julio Cordero, Gergana Dobreva, Thomas Wieland, and Joerg Heineke"]},"person":[{"display":"Keles, Merve","family":"Keles","given":"Merve","role":"aut"},{"given":"Steve","role":"aut","display":"Grein, Steve","family":"Grein"},{"role":"aut","given":"Natali","family":"Froese","display":"Froese, Natali"},{"role":"aut","given":"Dagmar","family":"Wirth","display":"Wirth, Dagmar"},{"display":"Trogisch, Felix","family":"Trogisch","given":"Felix","role":"aut"},{"family":"Wardman","display":"Wardman, Rhys","role":"aut","given":"Rhys"},{"family":"Hemanna","display":"Hemanna, Shruthi","role":"aut","given":"Shruthi"},{"family":"Weinzierl","display":"Weinzierl, Nina","role":"aut","given":"Nina"},{"given":"Philipp-Sebastian","role":"aut","display":"Reiners-Koch, Philipp-Sebastian","family":"Reiners-Koch"},{"given":"Stefanie","role":"aut","display":"Uhlig, Stefanie","family":"Uhlig"},{"display":"Lomada, Santosh K.","family":"Lomada","given":"Santosh K.","role":"aut"},{"given":"Gesine M.","role":"aut","display":"Dittrich, Gesine M.","family":"Dittrich"},{"role":"aut","given":"Malgorzata","family":"Szaroszyk","display":"Szaroszyk, Malgorzata"},{"given":"Ricarda","role":"aut","display":"Haustein, Ricarda","family":"Haustein"},{"display":"Hegermann, Jan","family":"Hegermann","given":"Jan","role":"aut"},{"display":"Martin Garrido, Abel","family":"Martin Garrido","given":"Abel","role":"aut"},{"display":"Bauersachs, Johann","family":"Bauersachs","given":"Johann","role":"aut"},{"display":"Frank, Derk","family":"Frank","given":"Derk","role":"aut"},{"role":"aut","given":"Norbert","family":"Frey","display":"Frey, Norbert"},{"role":"aut","given":"Karen","family":"Bieback","display":"Bieback, Karen"},{"given":"Julio","role":"aut","display":"Cordero, Julio","family":"Cordero"},{"role":"aut","given":"Gergana","family":"Dobreva","display":"Dobreva, Gergana"},{"role":"aut","given":"Thomas","family":"Wieland","display":"Wieland, Thomas"},{"family":"Heineke","display":"Heineke, Jörg","role":"aut","given":"Jörg"}],"id":{"eki":["1907199829"],"doi":["10.1016/j.omtn.2024.102306"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"noteIll":"Illustrationen","extent":"22 S."}],"relHost":[{"id":{"issn":["2162-2531"],"eki":["718632702"],"zdb":["2662631-7"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Molecular therapy","partname":"Nucleic Acids","title":"Molecular therapy"}],"physDesc":[{"extent":"Online-Ressource"}],"titleAlt":[{"title":"Molecular Therapy / Nucleic Acids"}],"disp":"Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodelingMolecular therapy. Nucleic Acids","part":{"issue":"3","pages":"1-22","volume":"35","year":"2024","text":"35(2024), 3, Artikel-ID 102306, Seite 1-22","extent":"22"},"pubHistory":["1.2012 -"],"name":{"displayForm":["American Society of Gene & Cell Therapy"]},"language":["eng"],"recId":"718632702","note":["Gesehen am 19. Januar 2017"],"origin":[{"dateIssuedDisp":"2012-","publisher":"Nature Publ. Group","dateIssuedKey":"2012","publisherPlace":"New York, NY"}]}],"title":[{"title_sort":"Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling","title":"Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling"}]} | ||
| SRT | |a KELESMERVEENDOTHELIA1020 | ||