Detection of CBP rearrangements in acute myelogenous leukemia with t(8;16)
The CREB-binding protein (CBP) is a large nuclear protein that regulates many signal transduction pathways and is involved in chromatin-mediated transcription. The translocation t(8;16)(p11;p13.3) consistently disrupts two genes: the CBP gene on chromosome band 16p13.3 and the MOZ gene on chromosome...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 December 1997
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| In: |
Leukemia
Year: 1997, Volume: 11, Issue: 12, Pages: 2087-2096 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/sj.leu.2400882 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.leu.2400882 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/2400882 
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| Author Notes: | R.H. Giles, J. G. Dauwerse, C. Higgins, F. Petrij, J.W. Wessels, G.C. Beverstock, H. Döhner, M. Jotterand-Bellomo, J.H.F. Falkenburg, R.M. Slater, G.-J. B. van Ommen, A. Hagemeijer, B.A. van der Reijden, M.H. Breuning |
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| 245 | 1 | 0 | |a Detection of CBP rearrangements in acute myelogenous leukemia with t(8;16) |c R.H. Giles, J. G. Dauwerse, C. Higgins, F. Petrij, J.W. Wessels, G.C. Beverstock, H. Döhner, M. Jotterand-Bellomo, J.H.F. Falkenburg, R.M. Slater, G.-J. B. van Ommen, A. Hagemeijer, B.A. van der Reijden, M.H. Breuning |
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| 520 | |a The CREB-binding protein (CBP) is a large nuclear protein that regulates many signal transduction pathways and is involved in chromatin-mediated transcription. The translocation t(8;16)(p11;p13.3) consistently disrupts two genes: the CBP gene on chromosome band 16p13.3 and the MOZ gene on chromosome band 8p11. Although a fusion of these two genes as a result of the translocation is expected, attempts at detecting the fusion transcript by reverse transcriptase polymerase chain reaction (RT-PCR) have proven difficult; to date, only one in-frame CBP/MOZ fusion transcript has been reported. We therefore sought other reliable means of detecting CBP rearrangements. We applied fluorescence in situ hybridization (FISH) and Southern blot analyses to a series of AML patients with a t(8;16) and detected DNA rearrangements of both the CBP and the MOZ loci in all cases tested. All six cases examined for CBP rearrangements have breakpoints within a 13 kb breakpoint cluster region at the 5′ end of the CBP gene. Additionally, we used a MOZ cDNA probe to construct a surrounding cosmid contig and detect DNA rearrangements in three t(8;16) cases, all of which display rearrangements within a 6 kb genomic fragment of the MOZ gene. We have thus developed a series of cosmid probes that consistently detect the disruption of the CBP gene in t(8;16) patients. These clones could potentially be used to screen other cancer-associated or congenital translocations involving chromosome band 16p13.3 as well. | ||
| 650 | 4 | |a Cancer Research | |
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| 650 | 4 | |a Intensive / Critical Care Medicine | |
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| 650 | 4 | |a Medicine/Public Health | |
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| 700 | 1 | |a Dauwerse, J. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Higgins, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Petrij, F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wessels, J. W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beverstock, G. C. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Hagemeijer, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a van der Reijden, B. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Breuning, M. H. |e VerfasserIn |4 aut | |
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