High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer
Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (B...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2024
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| In: |
Archives of gynecology and obstetrics
Year: 2024, Jahrgang: 309, Heft: 6, Pages: 2789-2798 |
| ISSN: | 1432-0711 |
| DOI: | 10.1007/s00404-024-07434-0 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00404-024-07434-0 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00404-024-07434-0 
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| Verfasserangaben: | Andy Göbel, Tilman D. Rachner, Oliver Hoffmann, Daniel Martin Klotz, Sabine Kasimir-Bauer, Rainer Kimmig, Lorenz C. Hofbauer, Ann-Kathrin Bittner |
| Zusammenfassung: | Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (BC), high intratumoral LRG-1 protein expression levels are associated with reduced survival. In this study, we assessed serum levels of LRG-1 in patients with early BC and investigated its correlation with the presence of disseminated tumor cells (DTCs) in the bone marrow and survival outcomes. |
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| Beschreibung: | Online veröffentlicht am 28. Februar 2024 Gesehen am 04.11.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1432-0711 |
| DOI: | 10.1007/s00404-024-07434-0 |