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Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy

Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant-type hemispheric glioma (IHG) but also in other pHGG and are associat...

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Main Authors: Zuckermann, Marc (Author) , He, Chen (Author) , Andrews, Jared (Author) , Bagchi, Aditi (Author) , Sloan-Henry, Roketa (Author) , Bianski, Brandon (Author) , Xie, Jia (Author) , Wang, Yingzhe (Author) , Twarog, Nathaniel (Author) , Onar-Thomas, Arzu (Author) , Ernst, Kati (Author) , Yang, Lei (Author) , Li, Yong (Author) , Zhu, Xiaoyan (Author) , Ocasio, Jennifer K. (Author) , Budd, Kaitlin M. (Author) , Dalton, James (Author) , Li, Xiaoyu (Author) , Chepyala, Divyabharathi (Author) , Zhang, Junyuan (Author) , Xu, Ke (Author) , Hover, Laura (Author) , Roach, Jordan T. (Author) , Chan, Kenneth Chun-Ho (Author) , Hofmann, Nina (Author) , McKinnon, Peter J. (Author) , Pfister, Stefan (Author) , Shelat, Anang A. (Author) , Rankovic, Zoran (Author) , Freeman, Burgess B. (Author) , Chiang, Jason (Author) , Jones, David T. W. (Author) , Tinkle, Christopher L. (Author) , Baker, Suzanne J. (Author)
Format: Article (Journal)
Language:English
Published: 07 June 2024
In: Molecular cancer
Year: 2024, Volume: 23, Pages: 1-19
ISSN:1476-4598
DOI:10.1186/s12943-024-02027-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12943-024-02027-6
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Author Notes:Marc Zuckermann, Chen He, Jared Andrews, Aditi Bagchi, Roketa Sloan-Henry, Brandon Bianski, Jia Xie, Yingzhe Wang, Nathaniel Twarog, Arzu Onar-Thomas, Kati J. Ernst, Lei Yang, Yong Li, Xiaoyan Zhu, Jennifer K. Ocasio, Kaitlin M. Budd, James Dalton, Xiaoyu Li, Divyabharathi Chepyala, Junyuan Zhang, Ke Xu, Laura Hover, Jordan T. Roach, Kenneth Chun-Ho Chan, Nina Hofmann, Peter J. McKinnon, Stefan M. Pfister, Anang A. Shelat, Zoran Rankovic, Burgess B. Freeman, Jason Chiang, David T.W. Jones, Christopher L. Tinkle and Suzanne J. Baker
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Summary:Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant-type hemispheric glioma (IHG) but also in other pHGG and are associated with devastating morbidity and mortality.
Item Description:Gesehen am 04.11.2024
Physical Description:Online Resource
ISSN:1476-4598
DOI:10.1186/s12943-024-02027-6

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