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Cardiac ageing: from hallmarks to therapeutic opportunities

Cardiac ageing is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular, and functional changes associated with cardiac ageing and heart failure with preserve...

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Hauptverfasser: Hastings, Margaret H. (Verfasst von) , Zhou, Qiulian (Verfasst von) , Wu, Chao (Verfasst von) , Shabani, Parisa (Verfasst von) , Huang, Shengyuan (Verfasst von) , Yu, Xuejing (Verfasst von) , Singh, Anand P (Verfasst von) , Guseh, J Sawalla (Verfasst von) , Li, Haobo (Verfasst von) , Lerchenmüller, Carolin (Verfasst von) , Rosenzweig, Anthony (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 June 2024
In: Cardiovascular research
Year: 2024, Pages: 1-15
ISSN:1755-3245
DOI:10.1093/cvr/cvae124
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1093/cvr/cvae124
Verlag, kostenfrei, Volltext: https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae124/7699121
Volltext
Verfasserangaben:Margaret H Hastings, Qiulian Zhou, Chao Wu, Parisa Shabani, Shengyuan Huang, Xuejing Yu, Anand P Singh, J Sawalla Guseh, Haobo Li, Carolin Lerchenmüller and Anthony Rosenzweig
Beschreibung
Zusammenfassung:Cardiac ageing is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular, and functional changes associated with cardiac ageing and heart failure with preserved ejection fraction (HFpEF). Key molecular mediators are considered within the framework of the established hallmarks of ageing, with particular attention to promising therapeutic candidates. We further delineate the differential impacts of ageing on cardiac structure and function in men and women, addressing hormonal and chromosomal influences. The protective and mitigating effects of exercise in cardiac ageing and HFpEF in particular are discussed, as an inspiration for the identification of pathways that mitigate biological ageing. We also emphasize how much remains to be learned and the importance of these efforts in enhancing the cardiac health of ageing populations worldwide.
Beschreibung:Gesehen am 04.11.2024
Beschreibung:Online Resource
ISSN:1755-3245
DOI:10.1093/cvr/cvae124

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