Cardiac ageing: from hallmarks to therapeutic opportunities
Cardiac ageing is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular, and functional changes associated with cardiac ageing and heart failure with preserve...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 June 2024
|
| In: |
Cardiovascular research
Year: 2024, Pages: 1-15 |
| ISSN: | 1755-3245 |
| DOI: | 10.1093/cvr/cvae124 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1093/cvr/cvae124 Verlag, kostenfrei, Volltext: https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae124/7699121 
|
| Verfasserangaben: | Margaret H Hastings, Qiulian Zhou, Chao Wu, Parisa Shabani, Shengyuan Huang, Xuejing Yu, Anand P Singh, J Sawalla Guseh, Haobo Li, Carolin Lerchenmüller and Anthony Rosenzweig |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1907498788 | ||
| 003 | DE-627 | ||
| 005 | 20241205184253.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241104s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/cvr/cvae124 |2 doi | |
| 035 | |a (DE-627)1907498788 | ||
| 035 | |a (DE-599)KXP1907498788 | ||
| 035 | |a (OCoLC)1475637289 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hastings, Margaret H. |e VerfasserIn |0 (DE-588)1347179208 |0 (DE-627)1907499652 |4 aut | |
| 245 | 1 | 0 | |a Cardiac ageing |b from hallmarks to therapeutic opportunities |c Margaret H Hastings, Qiulian Zhou, Chao Wu, Parisa Shabani, Shengyuan Huang, Xuejing Yu, Anand P Singh, J Sawalla Guseh, Haobo Li, Carolin Lerchenmüller and Anthony Rosenzweig |
| 264 | 1 | |c 26 June 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.11.2024 | ||
| 520 | |a Cardiac ageing is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular, and functional changes associated with cardiac ageing and heart failure with preserved ejection fraction (HFpEF). Key molecular mediators are considered within the framework of the established hallmarks of ageing, with particular attention to promising therapeutic candidates. We further delineate the differential impacts of ageing on cardiac structure and function in men and women, addressing hormonal and chromosomal influences. The protective and mitigating effects of exercise in cardiac ageing and HFpEF in particular are discussed, as an inspiration for the identification of pathways that mitigate biological ageing. We also emphasize how much remains to be learned and the importance of these efforts in enhancing the cardiac health of ageing populations worldwide. | ||
| 700 | 1 | |a Zhou, Qiulian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wu, Chao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shabani, Parisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Huang, Shengyuan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yu, Xuejing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Singh, Anand P |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guseh, J Sawalla |e VerfasserIn |4 aut | |
| 700 | 1 | |a Li, Haobo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lerchenmüller, Carolin |d 1983- |e VerfasserIn |0 (DE-588)1034967509 |0 (DE-627)746579918 |0 (DE-576)382589661 |4 aut | |
| 700 | 1 | |a Rosenzweig, Anthony |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cardiovascular research |d Oxford : Oxford University Press, 1967 |g (2024), Artikel-ID cvae124, Seite 1-15 |h Online-Ressource |w (DE-627)306654393 |w (DE-600)1499917-1 |w (DE-576)081984685 |x 1755-3245 |7 nnas |a Cardiac ageing from hallmarks to therapeutic opportunities |
| 773 | 1 | 8 | |g year:2024 |g elocationid:cvae124 |g pages:1-15 |g extent:15 |a Cardiac ageing from hallmarks to therapeutic opportunities |
| 856 | 4 | 0 | |u https://doi.org/10.1093/cvr/cvae124 |x Resolving-System |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae124/7699121 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241104 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1034967509 |a Lerchenmüller, Carolin |m 1034967509:Lerchenmüller, Carolin |d 50000 |e 50000PL1034967509 |k 0/50000/ |p 10 | ||
| 999 | |a KXP-PPN1907498788 |e 4609868520 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"15 S.","noteIll":"Illustrationen"}],"relHost":[{"id":{"eki":["306654393"],"zdb":["1499917-1"],"issn":["1755-3245"]},"origin":[{"publisherPlace":"Oxford ; Amsterdam [u.a.]","dateIssuedDisp":"1967-","publisher":"Oxford University Press ; Elsevier Science","dateIssuedKey":"1967"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cardiovascular research","title":"Cardiovascular research"}],"part":{"extent":"15","text":"(2024), Artikel-ID cvae124, Seite 1-15","pages":"1-15","year":"2024"},"pubHistory":["1.1967 -"],"language":["eng"],"recId":"306654393","note":["Gesehen am 01.12.2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Cardiac ageing from hallmarks to therapeutic opportunitiesCardiovascular research"}],"name":{"displayForm":["Margaret H Hastings, Qiulian Zhou, Chao Wu, Parisa Shabani, Shengyuan Huang, Xuejing Yu, Anand P Singh, J Sawalla Guseh, Haobo Li, Carolin Lerchenmüller and Anthony Rosenzweig"]},"origin":[{"dateIssuedDisp":"26 June 2024","dateIssuedKey":"2024"}],"id":{"eki":["1907498788"],"doi":["10.1093/cvr/cvae124"]},"note":["Gesehen am 04.11.2024"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1907498788","person":[{"family":"Hastings","given":"Margaret H.","roleDisplay":"VerfasserIn","display":"Hastings, Margaret H.","role":"aut"},{"family":"Zhou","given":"Qiulian","display":"Zhou, Qiulian","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Chao","family":"Wu","role":"aut","display":"Wu, Chao","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Shabani, Parisa","role":"aut","family":"Shabani","given":"Parisa"},{"role":"aut","display":"Huang, Shengyuan","roleDisplay":"VerfasserIn","given":"Shengyuan","family":"Huang"},{"role":"aut","display":"Yu, Xuejing","roleDisplay":"VerfasserIn","given":"Xuejing","family":"Yu"},{"given":"Anand P","family":"Singh","role":"aut","roleDisplay":"VerfasserIn","display":"Singh, Anand P"},{"display":"Guseh, J Sawalla","roleDisplay":"VerfasserIn","role":"aut","family":"Guseh","given":"J Sawalla"},{"roleDisplay":"VerfasserIn","display":"Li, Haobo","role":"aut","family":"Li","given":"Haobo"},{"role":"aut","display":"Lerchenmüller, Carolin","roleDisplay":"VerfasserIn","given":"Carolin","family":"Lerchenmüller"},{"given":"Anthony","family":"Rosenzweig","role":"aut","display":"Rosenzweig, Anthony","roleDisplay":"VerfasserIn"}],"title":[{"subtitle":"from hallmarks to therapeutic opportunities","title":"Cardiac ageing","title_sort":"Cardiac ageing"}]} | ||
| SRT | |a HASTINGSMACARDIACAGE2620 | ||