A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics: comment

Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Meyer, Miriam (VerfasserIn) , Mahr, Andrea (VerfasserIn) , Brewer, Joanna (VerfasserIn) , Daniel, Volker (VerfasserIn) , Dell‘Aringa, Justine (VerfasserIn) , Goldstone, Tony (VerfasserIn) , Hersey, Sarah (VerfasserIn) , Johnston, Ian (VerfasserIn) , Larson, Pamela (VerfasserIn) , Loveridge, Michael (VerfasserIn) , MacBeath, Gavin (VerfasserIn) , Moyer, Mark (VerfasserIn) , Nagorsen, Dirk (VerfasserIn) , Papa, Sophie (VerfasserIn) , Peiser, Leanne (VerfasserIn) , Ranade, Koustubh (VerfasserIn) , Rizzi, Ruben (VerfasserIn) , Roers, Axel (VerfasserIn) , Schendel, Dolores (VerfasserIn) , Sivakumar, Pallavur (VerfasserIn) , Tran, Eric (VerfasserIn) , Türeci, Özlem (VerfasserIn) , Weigand, Luise (VerfasserIn) , Wennborg, Anders (VerfasserIn) , Williams, Dennis (VerfasserIn) , Yee, Cassian (VerfasserIn) , Britten, Cedrik Michael (VerfasserIn)
Dokumenttyp: Article (Journal) Editorial
Sprache:Englisch
Veröffentlicht: 29 November 2023
In: Nature reviews. Drug discovery
Year: 2024, Jahrgang: 23, Heft: 1, Pages: 1-2
ISSN:1474-1784
DOI:10.1038/d41573-023-00189-4
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/d41573-023-00189-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/d41573-023-00189-4
Volltext
Verfasserangaben:Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur Sivakumar, Eric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee & Cedrik M. Britten

MARC

LEADER 00000caa a2200000 c 4500
001 1907623299
003 DE-627
005 20241205184534.0
007 cr uuu---uuuuu
008 241105s2024 xx |||||o 00| ||eng c
024 7 |a 10.1038/d41573-023-00189-4  |2 doi 
035 |a (DE-627)1907623299 
035 |a (DE-599)KXP1907623299 
035 |a (OCoLC)1475637356 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Meyer, Miriam  |e VerfasserIn  |0 (DE-588)1347313656  |0 (DE-627)1907624309  |4 aut 
245 1 2 |a A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics  |b comment  |c Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur Sivakumar, Eric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee & Cedrik M. Britten 
264 1 |c 29 November 2023 
300 |a 2 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 05.11.2024 
520 |a Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics. 
650 4 |a Biomedicine 
650 4 |a Biotechnology 
650 4 |a Cancer Research 
650 4 |a general 
650 4 |a Medicinal Chemistry 
650 4 |a Molecular Medicine 
650 4 |a Pharmacology/Toxicology 
700 1 |a Mahr, Andrea  |e VerfasserIn  |4 aut 
700 1 |a Brewer, Joanna  |e VerfasserIn  |4 aut 
700 1 |a Daniel, Volker  |e VerfasserIn  |0 (DE-588)1058939513  |0 (DE-627)79784418X  |0 (DE-576)166309168  |4 aut 
700 1 |a Dell‘Aringa, Justine  |e VerfasserIn  |4 aut 
700 1 |a Goldstone, Tony  |e VerfasserIn  |4 aut 
700 1 |a Hersey, Sarah  |e VerfasserIn  |4 aut 
700 1 |a Johnston, Ian  |e VerfasserIn  |4 aut 
700 1 |a Larson, Pamela  |e VerfasserIn  |4 aut 
700 1 |a Loveridge, Michael  |e VerfasserIn  |4 aut 
700 1 |a MacBeath, Gavin  |e VerfasserIn  |4 aut 
700 1 |a Moyer, Mark  |e VerfasserIn  |4 aut 
700 1 |a Nagorsen, Dirk  |e VerfasserIn  |4 aut 
700 1 |a Papa, Sophie  |e VerfasserIn  |4 aut 
700 1 |a Peiser, Leanne  |e VerfasserIn  |4 aut 
700 1 |a Ranade, Koustubh  |e VerfasserIn  |4 aut 
700 1 |a Rizzi, Ruben  |e VerfasserIn  |4 aut 
700 1 |a Roers, Axel  |e VerfasserIn  |0 (DE-588)1266471456  |0 (DE-627)1815283327  |4 aut 
700 1 |a Schendel, Dolores  |e VerfasserIn  |4 aut 
700 1 |a Sivakumar, Pallavur  |e VerfasserIn  |4 aut 
700 1 |a Tran, Eric  |e VerfasserIn  |4 aut 
700 1 |a Türeci, Özlem  |e VerfasserIn  |4 aut 
700 1 |a Weigand, Luise  |e VerfasserIn  |4 aut 
700 1 |a Wennborg, Anders  |e VerfasserIn  |4 aut 
700 1 |a Williams, Dennis  |e VerfasserIn  |4 aut 
700 1 |a Yee, Cassian  |e VerfasserIn  |4 aut 
700 1 |a Britten, Cedrik Michael  |e VerfasserIn  |0 (DE-588)1054233179  |0 (DE-627)79123617X  |0 (DE-576)410086495  |4 aut 
773 0 8 |i Enthalten in  |t Nature reviews. Drug discovery  |d London : Nature Publ. Group, 2002  |g 23(2024), 1, Seite 1-2  |h Online-Ressource  |w (DE-627)336452497  |w (DE-600)2061062-2  |w (DE-576)100800629  |x 1474-1784  |7 nnas  |a A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics comment 
773 1 8 |g volume:23  |g year:2024  |g number:1  |g pages:1-2  |g extent:2  |a A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics comment 
856 4 0 |u https://doi.org/10.1038/d41573-023-00189-4  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/d41573-023-00189-4  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20241105 
993 |a Editorial 
994 |a 2024 
998 |g 1266471456  |a Roers, Axel  |m 1266471456:Roers, Axel  |d 910000  |d 911600  |d 50000  |e 910000PR1266471456  |e 911600PR1266471456  |e 50000PR1266471456  |k 0/910000/  |k 1/910000/911600/  |k 0/50000/  |p 18 
998 |g 1058939513  |a Daniel, Volker  |m 1058939513:Daniel, Volker  |d 50000  |e 50000PD1058939513  |k 0/50000/  |p 4 
999 |a KXP-PPN1907623299  |e 4610214040 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"2 S."}],"title":[{"subtitle":"comment","title":"A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics","title_sort":"call to adapt the regulation of HLA testing for T cell receptor-based therapeutics"}],"person":[{"family":"Meyer","given":"Miriam","role":"aut","display":"Meyer, Miriam"},{"display":"Mahr, Andrea","family":"Mahr","given":"Andrea","role":"aut"},{"family":"Brewer","role":"aut","given":"Joanna","display":"Brewer, Joanna"},{"display":"Daniel, Volker","family":"Daniel","given":"Volker","role":"aut"},{"display":"Dell‘Aringa, Justine","family":"Dell‘Aringa","given":"Justine","role":"aut"},{"display":"Goldstone, Tony","family":"Goldstone","role":"aut","given":"Tony"},{"display":"Hersey, Sarah","role":"aut","given":"Sarah","family":"Hersey"},{"display":"Johnston, Ian","family":"Johnston","given":"Ian","role":"aut"},{"family":"Larson","given":"Pamela","role":"aut","display":"Larson, Pamela"},{"given":"Michael","role":"aut","family":"Loveridge","display":"Loveridge, Michael"},{"display":"MacBeath, Gavin","role":"aut","given":"Gavin","family":"MacBeath"},{"display":"Moyer, Mark","family":"Moyer","role":"aut","given":"Mark"},{"role":"aut","given":"Dirk","family":"Nagorsen","display":"Nagorsen, Dirk"},{"family":"Papa","role":"aut","given":"Sophie","display":"Papa, Sophie"},{"display":"Peiser, Leanne","family":"Peiser","role":"aut","given":"Leanne"},{"display":"Ranade, Koustubh","family":"Ranade","role":"aut","given":"Koustubh"},{"family":"Rizzi","role":"aut","given":"Ruben","display":"Rizzi, Ruben"},{"role":"aut","given":"Axel","family":"Roers","display":"Roers, Axel"},{"display":"Schendel, Dolores","role":"aut","given":"Dolores","family":"Schendel"},{"display":"Sivakumar, Pallavur","given":"Pallavur","role":"aut","family":"Sivakumar"},{"role":"aut","given":"Eric","family":"Tran","display":"Tran, Eric"},{"family":"Türeci","given":"Özlem","role":"aut","display":"Türeci, Özlem"},{"family":"Weigand","role":"aut","given":"Luise","display":"Weigand, Luise"},{"role":"aut","given":"Anders","family":"Wennborg","display":"Wennborg, Anders"},{"display":"Williams, Dennis","given":"Dennis","role":"aut","family":"Williams"},{"display":"Yee, Cassian","family":"Yee","given":"Cassian","role":"aut"},{"family":"Britten","given":"Cedrik Michael","role":"aut","display":"Britten, Cedrik Michael"}],"recId":"1907623299","name":{"displayForm":["Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur Sivakumar, Eric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee & Cedrik M. Britten"]},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"29 November 2023"}],"id":{"doi":["10.1038/d41573-023-00189-4"],"eki":["1907623299"]},"note":["Gesehen am 05.11.2024"],"relHost":[{"title":[{"partname":"Drug discovery","title":"Nature reviews","title_sort":"Nature reviews"}],"titleAlt":[{"title":"Nature reviews / Drug discovery"},{"title":"Drug discovery"}],"note":["Gesehen am 11.01.2019"],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2002 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisher":"Nature Publ. Group","dateIssuedKey":"2002","dateIssuedDisp":"2002-","publisherPlace":"London"}],"id":{"issn":["1474-1784"],"zdb":["2061062-2"],"eki":["336452497"]},"part":{"issue":"1","year":"2024","volume":"23","pages":"1-2","extent":"2","text":"23(2024), 1, Seite 1-2"},"recId":"336452497","disp":"A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics commentNature reviews. Drug discovery"}]} 
SRT |a MEYERMIRIACALLTOADAP2920