A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics: comment
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
29 November 2023
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| In: |
Nature reviews. Drug discovery
Year: 2024, Jahrgang: 23, Heft: 1, Pages: 1-2 |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/d41573-023-00189-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/d41573-023-00189-4 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/d41573-023-00189-4 |
| Verfasserangaben: | Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur Sivakumar, Eric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee & Cedrik M. Britten |
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| 245 | 1 | 2 | |a A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics |b comment |c Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur Sivakumar, Eric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee & Cedrik M. Britten |
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| 520 | |a Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics. | ||
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