Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization1
Recently, the D13S25 locus, which is in close proximity to the retinoblastoma gene (RB-1) on chromosome band 13q14, was discussed to play a role in the pathogenesis of B-CLL. In the present study, we isolated two overlapping genomic DNA clones (termed c13S25) containing the D13S25 DNA segment and us...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 01 1995
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| In: |
Cancer research
Year: 1995, Volume: 55, Issue: 16, Pages: 3475-3477 |
| ISSN: | 1538-7445 |
| Online Access: |
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| Author Notes: | Stephan Stilgenbauer, Elke Leupolt, Sybille Ohl, Gunther Weiß, Martin Schröder, Konstanze Fischer, Martin Bentz, Peter Lichter, Hartmut Döhner |
MARC
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| 245 | 1 | 0 | |a Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization1 |c Stephan Stilgenbauer, Elke Leupolt, Sybille Ohl, Gunther Weiß, Martin Schröder, Konstanze Fischer, Martin Bentz, Peter Lichter, Hartmut Döhner |
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| 520 | |a Recently, the D13S25 locus, which is in close proximity to the retinoblastoma gene (RB-1) on chromosome band 13q14, was discussed to play a role in the pathogenesis of B-CLL. In the present study, we isolated two overlapping genomic DNA clones (termed c13S25) containing the D13S25 DNA segment and used them as probes to analyze 85 B-CLL cases by fluorescence in situ hybridization; of the 55 cases with two RB-1 copies, 13 exhibited hemizygous (n = 7) or homozygous (n = 6) deletion of D13S25. Of 29 cases with hemizygous deletion of RB-1, all but two also showed loss of D13S25 (hemizygous, n = 25; homozygous, n = 2). One case had a homozygous deletion of both loci. We conclude that deletion of D13S25 occurs in a substantial number of B-CLL without deletion of RB-1. However, in some cases there is deletion of RB-1 without loss of D13S25, suggesting that D13S25 is not the locus of the putative tumor suppressor gene. According to our data, such a gene is most likely located within the genomic region between D13S25 and RB-1. | ||
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