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Emerge of colorectal cancer in Lynch syndrome despite colonoscopy surveillance: a challenge of hide and seek

Even with colonoscopy surveillance, Lynch syndromes (LS) carriers still develop colorectal cancer (CRC). The cumulative incidence of CRCs under colonoscopy surveillance varies depending on the affected mismatch repair (MMR) gene. However, the precise mechanisms driving these epidemiological patterns...

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Hauptverfasser: Helderman, Noah (VerfasserIn) , van Leerdam, Monique E. (VerfasserIn) , Kloor, Matthias (VerfasserIn) , Ahadova, Aysel (VerfasserIn) , Nielsen, Maartje (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 March 2024
In: Critical reviews in oncology, hematology
Year: 2024, Jahrgang: 197, Pages: 104331-1-104331-11
ISSN:1879-0461
DOI:10.1016/j.critrevonc.2024.104331
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.critrevonc.2024.104331
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S104084282400074X
Volltext
Verfasserangaben:Noah C. Helderman, Monique E. van Leerdam, Matthias Kloor, Aysel Ahadova, Maartje Nielsen
Beschreibung
Zusammenfassung:Even with colonoscopy surveillance, Lynch syndromes (LS) carriers still develop colorectal cancer (CRC). The cumulative incidence of CRCs under colonoscopy surveillance varies depending on the affected mismatch repair (MMR) gene. However, the precise mechanisms driving these epidemiological patterns remain incompletely understood. In recent years, several potential mechanisms explaining the occurrence of CRCs during colonoscopy surveillance have been proposed in individuals with and without LS. These encompass biological factors like concealed/accelerated carcinogenesis through a bypassed adenoma stage and accelerated progression from adenomas. Alongside these, various colonoscopy-related factors may contribute to formation of CRCs under colonoscopy surveillance, like missed yet detectable (pre)cancerous lesions, detected yet incompletely removed (pre)cancerous lesions, and colonoscopy-induced carcinogenesis due to tumor cell reimplantation. In this comprehensive literature update, we reviewed these potential factors and evaluated their relevance to each MMR group in an attempt to raise further awareness and stimulate research regarding this conflicting phenomenon.
Beschreibung:Gesehen am 11.11.2024
Beschreibung:Online Resource
ISSN:1879-0461
DOI:10.1016/j.critrevonc.2024.104331

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