Cover Image

Network-based approach for drug repurposing against mpox

The current outbreak of mpox presents a significant threat to the global community. However, the lack of mpox-specific drugs necessitates the identification of additional candidates for clinical trials. In this study, a network medicine framework was used to investigate poxviruses-human interactions...

Full description

Saved in:
Bibliographic Details
Main Authors: Tang, Kang (Author) , Sun, Qianru (Author) , Zeng, Jinfeng (Author) , Tang, Jing (Author) , Cheng, Peiwen (Author) , Qiu, Zekai (Author) , Long, Haoyu (Author) , Chen, Yilin (Author) , Zhang, Chi (Author) , Wei, Jie (Author) , Qiu, Xiaoping (Author) , Jiang, Guozhi (Author) , Fang, Qianglin (Author) , Sun, Litao (Author) , Sun, Caijun (Author) , Du, Xiangjun (Author)
Format: Article (Journal)
Language:English
Published: 17 May 2024
In: International journal of biological macromolecules
Year: 2024, Volume: 270, Issue: 2, Pages: 1-10
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2024.132468
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijbiomac.2024.132468
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0141813024032732
Get full text
Author Notes:Kang Tang, Qianru Sun, Jinfeng Zeng, Jing Tang, Peiwen Cheng, Zekai Qiu, Haoyu Long, Yilin Chen, Chi Zhang, Jie Wei, Xiaoping Qiu, Guozhi Jiang, Qianglin Fang, Litao Sun, Caijun Sun, Xiangjun Du

MARC

LEADER 00000caa a2200000 c 4500
001 1908141220
003 DE-627
005 20241205185424.0
007 cr uuu---uuuuu
008 241111s2024 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.ijbiomac.2024.132468  |2 doi 
035 |a (DE-627)1908141220 
035 |a (DE-599)KXP1908141220 
035 |a (OCoLC)1475637898 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Tang, Kang  |e VerfasserIn  |0 (DE-588)1347897941  |0 (DE-627)1908142375  |4 aut 
245 1 0 |a Network-based approach for drug repurposing against mpox  |c Kang Tang, Qianru Sun, Jinfeng Zeng, Jing Tang, Peiwen Cheng, Zekai Qiu, Haoyu Long, Yilin Chen, Chi Zhang, Jie Wei, Xiaoping Qiu, Guozhi Jiang, Qianglin Fang, Litao Sun, Caijun Sun, Xiangjun Du 
264 1 |c 17 May 2024 
300 |b Illustrationen 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online verfügbar: 17 Mai 2024, Artikelversion: 18 Mai 2024 
500 |a Gesehen am 11.11.2024 
520 |a The current outbreak of mpox presents a significant threat to the global community. However, the lack of mpox-specific drugs necessitates the identification of additional candidates for clinical trials. In this study, a network medicine framework was used to investigate poxviruses-human interactions to identify potential drugs effective against the mpox virus (MPXV). The results indicated that poxviruses preferentially target hubs on the human interactome, and that these virally-targeted proteins (VTPs) tend to aggregate together within specific modules. Comorbidity analysis revealed that mpox is closely related to immune system diseases. Based on predicted drug-target interactions, 268 drugs were identified using the network proximity approach, among which 23 drugs displaying the least side-effects and significant proximity to MPXV were selected as the final candidates. Lastly, specific drugs were explored based on VTPs, differentially expressed proteins, and intermediate nodes, corresponding to different categories. These findings provide novel insights that can contribute to a deeper understanding of the pathogenesis of MPXV and development of ready-to-use treatment strategies based on drug repurposing. 
650 4 |a Comorbidity 
650 4 |a Drug repurposing 
650 4 |a Mpox 
650 4 |a Virushost interaction 
700 1 |a Sun, Qianru  |e VerfasserIn  |4 aut 
700 1 |a Zeng, Jinfeng  |e VerfasserIn  |4 aut 
700 1 |a Tang, Jing  |e VerfasserIn  |4 aut 
700 1 |a Cheng, Peiwen  |e VerfasserIn  |4 aut 
700 1 |a Qiu, Zekai  |e VerfasserIn  |0 (DE-588)1347898492  |0 (DE-627)1908143495  |4 aut 
700 1 |a Long, Haoyu  |e VerfasserIn  |4 aut 
700 1 |a Chen, Yilin  |e VerfasserIn  |4 aut 
700 1 |a Zhang, Chi  |e VerfasserIn  |4 aut 
700 1 |a Wei, Jie  |e VerfasserIn  |4 aut 
700 1 |a Qiu, Xiaoping  |e VerfasserIn  |4 aut 
700 1 |a Jiang, Guozhi  |e VerfasserIn  |4 aut 
700 1 |a Fang, Qianglin  |e VerfasserIn  |4 aut 
700 1 |a Sun, Litao  |e VerfasserIn  |4 aut 
700 1 |a Sun, Caijun  |e VerfasserIn  |4 aut 
700 1 |a Du, Xiangjun  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t International journal of biological macromolecules  |d New York, NY [u.a.] : Elsevier, 1979  |g 270(2024), 2 vom: Juni, Artikel-ID 132468, Seite 1-10  |h Online-Ressource  |w (DE-627)30089502X  |w (DE-600)1483284-7  |w (DE-576)259270814  |x 1879-0003  |7 nnas  |a Network-based approach for drug repurposing against mpox 
773 1 8 |g volume:270  |g year:2024  |g number:2  |g month:06  |g elocationid:132468  |g pages:1-10  |g extent:10  |a Network-based approach for drug repurposing against mpox 
856 4 0 |u https://doi.org/10.1016/j.ijbiomac.2024.132468  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0141813024032732  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20241111 
993 |a Article 
994 |a 2024 
998 |g 1347898492  |a Qiu, Zekai  |m 1347898492:Qiu, Zekai  |d 50000  |e 50000PQ1347898492  |k 0/50000/  |p 6 
999 |a KXP-PPN1908141220  |e 4612965272 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Kang Tang, Qianru Sun, Jinfeng Zeng, Jing Tang, Peiwen Cheng, Zekai Qiu, Haoyu Long, Yilin Chen, Chi Zhang, Jie Wei, Xiaoping Qiu, Guozhi Jiang, Qianglin Fang, Litao Sun, Caijun Sun, Xiangjun Du"]},"id":{"eki":["1908141220"],"doi":["10.1016/j.ijbiomac.2024.132468"]},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"17 May 2024"}],"relHost":[{"pubHistory":["1.1979 -"],"part":{"text":"270(2024), 2 vom: Juni, Artikel-ID 132468, Seite 1-10","volume":"270","extent":"10","year":"2024","pages":"1-10","issue":"2"},"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.10.10"],"disp":"Network-based approach for drug repurposing against mpoxInternational journal of biological macromolecules","language":["eng"],"recId":"30089502X","title":[{"subtitle":"structure, function and interactions","title":"International journal of biological macromolecules","title_sort":"International journal of biological macromolecules"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1979","publisher":"Elsevier","dateIssuedDisp":"1979-","publisherPlace":"New York, NY [u.a.]"}],"id":{"issn":["1879-0003"],"zdb":["1483284-7"],"eki":["30089502X"]}}],"physDesc":[{"extent":"10 S.","noteIll":"Illustrationen"}],"person":[{"given":"Kang","family":"Tang","role":"aut","roleDisplay":"VerfasserIn","display":"Tang, Kang"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Sun, Qianru","given":"Qianru","family":"Sun"},{"role":"aut","display":"Zeng, Jinfeng","roleDisplay":"VerfasserIn","given":"Jinfeng","family":"Zeng"},{"family":"Tang","given":"Jing","display":"Tang, Jing","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Cheng, Peiwen","roleDisplay":"VerfasserIn","given":"Peiwen","family":"Cheng"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Qiu, Zekai","given":"Zekai","family":"Qiu"},{"family":"Long","given":"Haoyu","display":"Long, Haoyu","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Chen, Yilin","roleDisplay":"VerfasserIn","role":"aut","family":"Chen","given":"Yilin"},{"given":"Chi","family":"Zhang","role":"aut","display":"Zhang, Chi","roleDisplay":"VerfasserIn"},{"given":"Jie","family":"Wei","role":"aut","roleDisplay":"VerfasserIn","display":"Wei, Jie"},{"given":"Xiaoping","family":"Qiu","role":"aut","display":"Qiu, Xiaoping","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Jiang, Guozhi","roleDisplay":"VerfasserIn","given":"Guozhi","family":"Jiang"},{"role":"aut","display":"Fang, Qianglin","roleDisplay":"VerfasserIn","given":"Qianglin","family":"Fang"},{"given":"Litao","family":"Sun","role":"aut","roleDisplay":"VerfasserIn","display":"Sun, Litao"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Sun, Caijun","given":"Caijun","family":"Sun"},{"family":"Du","given":"Xiangjun","display":"Du, Xiangjun","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"Network-based approach for drug repurposing against mpox","title_sort":"Network-based approach for drug repurposing against mpox"}],"language":["eng"],"recId":"1908141220","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online verfügbar: 17 Mai 2024, Artikelversion: 18 Mai 2024","Gesehen am 11.11.2024"]} 
SRT |a TANGKANGSUNETWORKBAS1720 

Similar Items