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Network-based approach for drug repurposing against mpox

The current outbreak of mpox presents a significant threat to the global community. However, the lack of mpox-specific drugs necessitates the identification of additional candidates for clinical trials. In this study, a network medicine framework was used to investigate poxviruses-human interactions...

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Hauptverfasser: Tang, Kang (VerfasserIn) , Sun, Qianru (VerfasserIn) , Zeng, Jinfeng (VerfasserIn) , Tang, Jing (VerfasserIn) , Cheng, Peiwen (VerfasserIn) , Qiu, Zekai (VerfasserIn) , Long, Haoyu (VerfasserIn) , Chen, Yilin (VerfasserIn) , Zhang, Chi (VerfasserIn) , Wei, Jie (VerfasserIn) , Qiu, Xiaoping (VerfasserIn) , Jiang, Guozhi (VerfasserIn) , Fang, Qianglin (VerfasserIn) , Sun, Litao (VerfasserIn) , Sun, Caijun (VerfasserIn) , Du, Xiangjun (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 May 2024
In: International journal of biological macromolecules
Year: 2024, Jahrgang: 270, Heft: 2, Pages: 1-10
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2024.132468
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijbiomac.2024.132468
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0141813024032732
Volltext
Verfasserangaben:Kang Tang, Qianru Sun, Jinfeng Zeng, Jing Tang, Peiwen Cheng, Zekai Qiu, Haoyu Long, Yilin Chen, Chi Zhang, Jie Wei, Xiaoping Qiu, Guozhi Jiang, Qianglin Fang, Litao Sun, Caijun Sun, Xiangjun Du
Beschreibung
Zusammenfassung:The current outbreak of mpox presents a significant threat to the global community. However, the lack of mpox-specific drugs necessitates the identification of additional candidates for clinical trials. In this study, a network medicine framework was used to investigate poxviruses-human interactions to identify potential drugs effective against the mpox virus (MPXV). The results indicated that poxviruses preferentially target hubs on the human interactome, and that these virally-targeted proteins (VTPs) tend to aggregate together within specific modules. Comorbidity analysis revealed that mpox is closely related to immune system diseases. Based on predicted drug-target interactions, 268 drugs were identified using the network proximity approach, among which 23 drugs displaying the least side-effects and significant proximity to MPXV were selected as the final candidates. Lastly, specific drugs were explored based on VTPs, differentially expressed proteins, and intermediate nodes, corresponding to different categories. These findings provide novel insights that can contribute to a deeper understanding of the pathogenesis of MPXV and development of ready-to-use treatment strategies based on drug repurposing.
Beschreibung:Online verfügbar: 17 Mai 2024, Artikelversion: 18 Mai 2024
Gesehen am 11.11.2024
Beschreibung:Online Resource
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2024.132468

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