rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells
  name:
    name part: Lairikyengbam, Divya
    name part: 1995-
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Wetterauer, Bernhard
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Schmiech, Michael
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Jahraus, Beate
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Kirchgessner, Henning
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Link, Pille
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Berschneider, Karina M.
    name part: 1992-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Beier, Verena
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Niesler, Beate
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Balta, Emre
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Samstag, Yvonne
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2024
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: Illustrationen
    extent: 20
  abstract: Introduction Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory milieu by secreting proinflammatory cytokines. Chamomilla recutita L. (chamomile) has been suggested for use in several inflammatory diseases, implying a capability to modulate T cells. Here, we have characterized and compared the effects of differently prepared chamomile extracts and characteristic pure compounds on the T cell redox milieu as well as on the migration, activation, proliferation, and cytokine production of primary human T cells. Methods Phytochemical analysis of the extracts was carried out by LC-MS/MS. Primary human T cells from peripheral blood (PBTs) were pretreated with aqueous or hydroethanolic chamomile extracts or pure compounds. Subsequently, the effects on intracellular ROS levels, SDF-1α induced T cell migration, T cell activation, proliferation, and cytokine production after TCR/CD3 and CD28 costimulation were determined. Gene expression profiling was performed using nCounter analysis, followed by ingenuity pathway analysis, and validation at protein levels. Results The tested chamomile extracts and pure compounds differentially affected intracellular ROS levels, migration, and activation of T cells. Three out of five differently prepared extracts and two out of three pure compounds diminished T cell proliferation. In line with these findings, LC-MS/MS analysis revealed high heterogeneity of phytochemicals among the different extracts. nCounter based gene expression profiling identified several genes related to T cell functions associated with activation and differentiation to be downregulated. Most prominently, apigenin significantly reduced granzyme B induction and cytotoxic T cell activity. Conclusion Our results demonstrate an anti-inflammatory effect …
  note: Divya Lairikyengbam, Bernhard Wetterauer, Michael Schmiech, Beate Jahraus, Henning Kirchgessner, Pille Wetterauer, Karina Berschneider, Verena Beier, Beate Niesler, Emre Balta and Yvonne Samstag
  note: Gesehen am 18.11.2024
  subject:
    topic: A-Bisabolol
  subject:
    topic: Apigenin
  subject:
    topic: Chamazulene
  subject:
    topic: Chamomilla recutita L. extracts
  subject:
    topic: Immunomodulation
  subject:
    topic: Inflammation
  subject:
    topic: LC-MS/MS Abbreviations CT: Chamomile aqueous total fermented extract
  subject:
    topic: Primary human T cells
  classification: 33
  related item:
    title info:
      title: Frontiers in immunology
    name:
      name part: Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells
    origin info:
      publisher: Lausanne : Frontiers Media, 2010
    physical description:
      extent: Online-Ressource
    identifier: 1664-3224
    identifier: (DE-627)657998354
    identifier: (DE-600)2606827-8
    identifier: (DE-576)343624834
    part:
      text: 15(2024) vom: 24. Apr., Artikel-ID 1388962, Seite 1-20
  related item:
    name:
      name part: Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells
    part:
      text: volume:15
    part:
      text: year:2024
    part:
      text: day:24
    part:
      text: month:04
    part:
      text: elocationid:1388962
    part:
      text: pages:1-20
    part:
      text: extent:20
  identifier: https://doi.org/10.3389/fimmu.2024.1388962
  identifier: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1388962/full
  record info:
    record content source: DE-627
    record creation date: 241118
    record change date: 20241205221005.0
    record identifier: 1908851058
    language of cataloging:
      language term: ger