Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scores
Background: Endovascular thrombectomy (EVT) reduces disability in patients with acute ischemic stroke (AIS); however, its efficacy in patients aged >80 years remains unclear. Objectives: This study aimed to assess the impact of premorbid modified Rankin Scale (pmRS) scores and age on patients wit...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 July 2024
|
| In: |
Frontiers in neurology
Year: 2024, Volume: 15, Pages: 1-19 |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2024.1418415 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fneur.2024.1418415 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1418415/full 
|
| Author Notes: | Franziska M. Ippen, Katharina Schregel, Matthias Ungerer, Manuel Feisst, Peter A. Ringleb and Christoph K. Gumbinger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1908887397 | ||
| 003 | DE-627 | ||
| 005 | 20241212100843.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241118s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fneur.2024.1418415 |2 doi | |
| 035 | |a (DE-627)1908887397 | ||
| 035 | |a (DE-599)KXP1908887397 | ||
| 035 | |a (OCoLC)1475647619 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ippen, Franziska M. |d 1988- |e VerfasserIn |0 (DE-588)1093609540 |0 (DE-627)853809771 |0 (DE-576)462741524 |4 aut | |
| 245 | 1 | 0 | |a Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scores |c Franziska M. Ippen, Katharina Schregel, Matthias Ungerer, Manuel Feisst, Peter A. Ringleb and Christoph K. Gumbinger |
| 264 | 1 | |c 03 July 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.11.2024 | ||
| 520 | |a Background: Endovascular thrombectomy (EVT) reduces disability in patients with acute ischemic stroke (AIS); however, its efficacy in patients aged >80 years remains unclear. Objectives: This study aimed to assess the impact of premorbid modified Rankin Scale (pmRS) scores and age on patients with AIS undergoing EVT and the effect of EVT on functional outcome and mortality.Methods: We conducted a retrospective cohort study and screened the Heidelberg Recanalization Registry (HeiReKa) database for patients with AIS between 1999 and 2021. Outcomes were stratified by age (<80, 80-89, and ≥90 years) and pmRS score (0-2 vs. 3-5). Adjusted odds ratios for outcomes and mortality at 3 months after treatment were examined. Results: Finally, 2,591 patients were included [including those aged ≥90 years (n = 158)]. Poor functional outcomes were associated with advanced age, vascular risk factors, stroke severity, and vessel status. Conversely, lower prestroke disability and younger age were associated with better outcomes and reduced mortality. A pmRS of 3-5 was associated with an increased risk of mortality and worse functional outcomes regardless of age. Notably, patients aged ≥90 years with a pmRS of 0-2 had significantly better outcomes than those aged <80 years with a pmRS of 3-5. Conclusion: Both age and pmRS are important in assessing the benefits of EVT. However, prestroke functional status might be more crucial than biological age in determining outcomes following EVT. | ||
| 650 | 4 | |a Acute ischemic stroke | |
| 650 | 4 | |a elderly patients | |
| 650 | 4 | |a Endovascular thrombectomy | |
| 650 | 4 | |a Outcome | |
| 650 | 4 | |a premorbid Rankin scale score | |
| 700 | 1 | |a Schregel, Katharina |e VerfasserIn |0 (DE-588)1215056605 |0 (DE-627)1726087360 |4 aut | |
| 700 | 1 | |a Ungerer, Matthias |e VerfasserIn |0 (DE-588)1075607981 |0 (DE-627)833532189 |0 (DE-576)444398759 |4 aut | |
| 700 | 1 | |a Feißt, Manuel |d 1989- |e VerfasserIn |0 (DE-588)1158520948 |0 (DE-627)1020533544 |0 (DE-576)504012312 |4 aut | |
| 700 | 1 | |a Ringleb, Peter A. |e VerfasserIn |0 (DE-588)1032676175 |0 (DE-627)73863364X |0 (DE-576)172917743 |4 aut | |
| 700 | 1 | |a Gumbinger, Christoph |e VerfasserIn |0 (DE-588)138155178 |0 (DE-627)696381117 |0 (DE-576)306183927 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in neurology |d Lausanne : Frontiers Research Foundation, 2008 |g 15(2024) vom: 3., Artikel-ID 1418415, Seite 1-19 |h Online-Ressource |w (DE-627)631498753 |w (DE-600)2564214-5 |w (DE-576)326550933 |x 1664-2295 |7 nnas |a Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scores |
| 773 | 1 | 8 | |g volume:15 |g year:2024 |g day:3 |g elocationid:1418415 |g pages:1-19 |g extent:10 |a Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scores |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fneur.2024.1418415 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1418415/full |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241118 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 138155178 |a Gumbinger, Christoph |m 138155178:Gumbinger, Christoph |d 910000 |d 911100 |d 50000 |e 910000PG138155178 |e 911100PG138155178 |e 50000PG138155178 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 6 |y j | ||
| 998 | |g 1032676175 |a Ringleb, Peter A. |m 1032676175:Ringleb, Peter A. |d 910000 |d 911100 |e 910000PR1032676175 |e 911100PR1032676175 |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1158520948 |a Feißt, Manuel |m 1158520948:Feißt, Manuel |d 910000 |d 911800 |e 910000PF1158520948 |e 911800PF1158520948 |k 0/910000/ |k 1/910000/911800/ |p 4 | ||
| 998 | |g 1075607981 |a Ungerer, Matthias |m 1075607981:Ungerer, Matthias |d 910000 |d 911100 |e 910000PU1075607981 |e 911100PU1075607981 |k 0/910000/ |k 1/910000/911100/ |p 3 | ||
| 998 | |g 1215056605 |a Schregel, Katharina |m 1215056605:Schregel, Katharina |d 910000 |d 911100 |e 910000PS1215056605 |e 911100PS1215056605 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 1093609540 |a Ippen, Franziska M. |m 1093609540:Ippen, Franziska M. |d 910000 |d 911100 |e 910000PI1093609540 |e 911100PI1093609540 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1908887397 |e 4616126097 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Franziska M. Ippen, Katharina Schregel, Matthias Ungerer, Manuel Feisst, Peter A. Ringleb and Christoph K. Gumbinger"]},"note":["Gesehen am 18.11.2024"],"recId":"1908887397","person":[{"given":"Franziska M.","family":"Ippen","display":"Ippen, Franziska M.","role":"aut"},{"role":"aut","given":"Katharina","display":"Schregel, Katharina","family":"Schregel"},{"given":"Matthias","family":"Ungerer","display":"Ungerer, Matthias","role":"aut"},{"given":"Manuel","family":"Feißt","display":"Feißt, Manuel","role":"aut"},{"given":"Peter A.","family":"Ringleb","display":"Ringleb, Peter A.","role":"aut"},{"family":"Gumbinger","display":"Gumbinger, Christoph","given":"Christoph","role":"aut"}],"physDesc":[{"extent":"10 S.","noteIll":"Illustrationen"}],"title":[{"title_sort":"Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scores","title":"Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scores"}],"relHost":[{"name":{"displayForm":["Frontiers Research Foundation"]},"pubHistory":["2008 -"],"recId":"631498753","note":["Gesehen am 18.08.20","Specialty sections: Autonomic Neuroscience; Brain Imaging Methods; Dementia; Endovascular and Interventional Neurology; Epilepsy; Headache Medicine and Facial Pain; Movement Disorders; Multiple Sclerosis and Neuroimmunology; Neurocritical and Neurohospitalist; Care; Neurodegeneration; Neurogenomics; Neurology Education; Neuromuscular Diseases; Neuro-Oncology; Neuro-Ophthalmology; Neuro-Otology; Neuropediatrics; Neuropharmacology; Neuroprosthetics; Neurotrauma; Sleep and Chronobiology; Spinal Cord Medicine; Sports Neurology; Stroke; Teleneurology"],"disp":"Outcomes in elderly patients undergoing endovascular thrombectomy in association with premorbid Rankin Scale scoresFrontiers in neurology","title":[{"title":"Frontiers in neurology","title_sort":"Frontiers in neurology"}],"physDesc":[{"extent":"Online-Ressource"}],"titleAlt":[{"title":"Autonomic Neuroscience"},{"title":"Brain Imaging Methods"},{"title":"Dementia"},{"title":"Endovascular and Interventional Neurology"},{"title":"Epilepsy"},{"title":"Headache Medicine and Facial Pain"},{"title":"Movement Disorders"},{"title":"Multiple Sclerosis and Neuroimmunology"},{"title":"Neurocritical and Neurohospitalist Care"},{"title":"Neurodegeneration"},{"title":"Neurogenomics"},{"title":"Neurology Education"},{"title":"Neuromuscular Diseases"},{"title":"Neuro-Oncology"},{"title":"Neuro-Ophthalmology"},{"title":"Neuro-Otology"},{"title":"Neuropediatrics"},{"title":"Neuropharmacology"},{"title":"Neuroprosthetics"},{"title":"Neurotrauma"},{"title":"Sleep and Chronobiology"},{"title":"Spinal Cord Medicine"},{"title":"Sports Neurology"},{"title":"Stroke"},{"title":"Teleneurology"}],"part":{"pages":"1-19","text":"15(2024) vom: 3., Artikel-ID 1418415, Seite 1-19","volume":"15","year":"2024","extent":"10"},"origin":[{"publisherPlace":"Lausanne","dateIssuedDisp":"2008-","publisher":"Frontiers Research Foundation","dateIssuedKey":"2008"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2564214-5"],"issn":["1664-2295"],"eki":["631498753"]},"language":["eng"]}],"origin":[{"dateIssuedDisp":"03 July 2024","dateIssuedKey":"2024"}],"language":["eng"],"id":{"eki":["1908887397"],"doi":["10.3389/fneur.2024.1418415"]},"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a IPPENFRANZOUTCOMESIN0320 | ||