Gold catalysis in quinoline synthesis
Quinolines are biologically and pharmaceutically important N-heterocyclic aromatic compounds, which have broad applications in medicinal chemistry. Thus, their efficient synthesis has attracted extensive attention, and a broad range of synthetic strategies have been established. Of note, gold-cataly...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 Jun 2024
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Chemical communications
Year: 2024, Jahrgang: 60, Heft: 55, Pages: 6999-7016 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/D4CC01915F |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/D4CC01915F Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc01915f 
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| Verfasserangaben: | Ximei Zhao, Guanghui Wang and A. Stephen K. Hashmi |
| Zusammenfassung: | Quinolines are biologically and pharmaceutically important N-heterocyclic aromatic compounds, which have broad applications in medicinal chemistry. Thus, their efficient synthesis has attracted extensive attention, and a broad range of synthetic strategies have been established. Of note, gold-catalyzed methodologies for the synthesis of quinolines have greatly advanced this field. Various gold-catalyzed intermolecular annulation reactions, such as annulations of aniline derivatives with carbonyl compounds or alkynes, annulations of anthranils with alkynes, and annulations based on A3-coupling reactions, as well as intramolecular cyclization reactions of azide-tethered alkynes, 1,2-diphenylethynes, and 2-ethynyl N-aryl indoles, have been developed. This review provides an overview of this exciting research area. Typical achievements in reaction methodologies and plausible reaction mechanisms are summarized. |
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| Beschreibung: | Gesehen am 19.11.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/D4CC01915F |