The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality
Objectives: The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 19, 2024
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| In: |
Clinical chemistry and laboratory medicine
Year: 2024, Pages: 1-12 |
| ISSN: | 1437-4331 |
| DOI: | 10.1515/cclm-2024-0391 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1515/cclm-2024-0391 Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/cclm-2024-0391/html 
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| Verfasserangaben: | Markus Herrmann, Martin H. Keppel, Sieglinde Zelzer, Nerea Alonso, Etienne Cavalier, Marcus Kleber, Dietmar Enko, Hubert Scharnagl, Stefan Pilz and Winfried März |
MARC
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| 245 | 1 | 4 | |a The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality |c Markus Herrmann, Martin H. Keppel, Sieglinde Zelzer, Nerea Alonso, Etienne Cavalier, Marcus Kleber, Dietmar Enko, Hubert Scharnagl, Stefan Pilz and Winfried März |
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| 520 | |a Objectives: The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH) 2 D] permits a functional assessment of vitamin D metabolism. The present study compared the associations of functional vitamin D deficiency and low vitamin D reservoirs with CVD mortality and CVD burden. Methods: 25(OH)D, 24,25(OH) 2 D, the degree of coronary obstruction on angiography, high-sensitive cardiac troponin T (hs-cTnT), N-terminal brain natriuretic peptide (NT-proBNP), and 10-year CVD mortality were obtained from 2,456 participants of the LURIC (Ludwigshafen Risk and Cardiovascular Health) study. Results: Neither low 25(OH)D concentrations nor functional vitamin D deficiency were associated with the number of atherosclerotic coronary arteries or the degree of coronary obstruction. Over a median follow-up of 9.9 years, 454 participants died (23.6%) due to CVD. CVD mortality was doubled in individuals with 25(OH)D concentrations below the widely used cut-off for deficiency of <50nmol/L [20ng/mL] (21.6 vs. 11.5%). In individuals with and without functional vitamin D deficiency, CVD mortality was 25.0 and 16.7%, respectively. NT-proBNP and heart failure prevalence were also higher in vitamin D deficient individuals. Conclusions: Vitamin D deficient individuals have markedly higher CVD mortality, but only marginally higher hs-cTnT concentrations. A higher prevalence of heart failure and higher NT-proBNP concentrations suggest a link between vitamin D deficiency and cardiac function. The traditional and metabolic assessment of vitamin D status showed comparable associations for the different parameters of cardiac health. | ||
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| 700 | 1 | |a Zelzer, Sieglinde |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alonso, Nerea |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Enko, Dietmar |e VerfasserIn |4 aut | |
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