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The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality

Objectives: The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH...

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Hauptverfasser: Herrmann, Markus (VerfasserIn) , Keppel, Martin H. (VerfasserIn) , Zelzer, Sieglinde (VerfasserIn) , Alonso, Nerea (VerfasserIn) , Cavalier, Etienne (VerfasserIn) , Kleber, Marcus E. (VerfasserIn) , Enko, Dietmar (VerfasserIn) , Scharnagl, Hubert (VerfasserIn) , Pilz, Stefan (VerfasserIn) , März, Winfried (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 19, 2024
In: Clinical chemistry and laboratory medicine
Year: 2024, Pages: 1-12
ISSN:1437-4331
DOI:10.1515/cclm-2024-0391
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1515/cclm-2024-0391
Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/cclm-2024-0391/html
Volltext
Verfasserangaben:Markus Herrmann, Martin H. Keppel, Sieglinde Zelzer, Nerea Alonso, Etienne Cavalier, Marcus Kleber, Dietmar Enko, Hubert Scharnagl, Stefan Pilz and Winfried März
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Zusammenfassung:Objectives: The role of vitamin D deficiency in cardiovascular disease (CVD) is controversial. Inherent biological and analytical limitations compromise the specificity of widely used 25-hydroxyvitamin D [25(OH)D] cut-offs. Simultaneous determination of 25(OH)D and 24,25-dihydroxyvitamin D [24,25(OH) 2 D] permits a functional assessment of vitamin D metabolism. The present study compared the associations of functional vitamin D deficiency and low vitamin D reservoirs with CVD mortality and CVD burden. Methods: 25(OH)D, 24,25(OH) 2 D, the degree of coronary obstruction on angiography, high-sensitive cardiac troponin T (hs-cTnT), N-terminal brain natriuretic peptide (NT-proBNP), and 10-year CVD mortality were obtained from 2,456 participants of the LURIC (Ludwigshafen Risk and Cardiovascular Health) study. Results: Neither low 25(OH)D concentrations nor functional vitamin D deficiency were associated with the number of atherosclerotic coronary arteries or the degree of coronary obstruction. Over a median follow-up of 9.9 years, 454 participants died (23.6%) due to CVD. CVD mortality was doubled in individuals with 25(OH)D concentrations below the widely used cut-off for deficiency of <50nmol/L [20ng/mL] (21.6 vs. 11.5%). In individuals with and without functional vitamin D deficiency, CVD mortality was 25.0 and 16.7%, respectively. NT-proBNP and heart failure prevalence were also higher in vitamin D deficient individuals. Conclusions: Vitamin D deficient individuals have markedly higher CVD mortality, but only marginally higher hs-cTnT concentrations. A higher prevalence of heart failure and higher NT-proBNP concentrations suggest a link between vitamin D deficiency and cardiac function. The traditional and metabolic assessment of vitamin D status showed comparable associations for the different parameters of cardiac health.
Beschreibung:Gesehen am 25.11.2024
Beschreibung:Online Resource
ISSN:1437-4331
DOI:10.1515/cclm-2024-0391

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