Poissonian cellular potts models reveal nonequilibrium kinetics of cell sorting
Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical timescale through Poissonian kinetics and by applying princ...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 June 2024
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| In: |
Physical review letters
Year: 2024, Volume: 132, Issue: 24, Pages: 1-7 |
| ISSN: | 1079-7114 |
| DOI: | 10.1103/PhysRevLett.132.248401 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1103/PhysRevLett.132.248401 Verlag, kostenfrei, Volltext: https://link.aps.org/doi/10.1103/PhysRevLett.132.248401 
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| Author Notes: | R. Belousov, S. Savino, P. Moghe, T. Hiiragi, L. Rondoni, and A. Erzberger |
| Summary: | Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical timescale through Poissonian kinetics and by applying principles of stochastic thermodynamics to separate thermal and relaxation effects from athermal noise and nonconservative forces. Our method accurately describes cell-sorting dynamics in mouse-embryo development and identifies the distinct contributions of nonequilibrium processes, e.g., cell growth and active fluctuations. |
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| Item Description: | Gesehen am 26.11.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1079-7114 |
| DOI: | 10.1103/PhysRevLett.132.248401 |