NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia
NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced mitophagy dependent on its active site phosphohistidine but not the NDPK function. Mice carrying a knock-in mutation in the Nme3...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 March 2024
|
| In: |
Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-20 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-46385-7 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-46385-7 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-46385-7 
|
| Verfasserangaben: | Chih-Wei Chen, Chi Su, Chang-Yu Huang, Xuan-Rong Huang, Xiaojing Cuili, Tung Chao, Chun-Hsiang Fan, Cheng-Wei Ting, Yi-Wei Tsai, Kai-Chien Yang, Ti-Yen Yeh, Sung-Tsang Hsieh, Yi-Ju Chen, Yuxi Feng, Tony Hunter & Zee-Fen Chang |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1909611662 | ||
| 003 | DE-627 | ||
| 005 | 20241205223115.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241127s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-024-46385-7 |2 doi | |
| 035 | |a (DE-627)1909611662 | ||
| 035 | |a (DE-599)KXP1909611662 | ||
| 035 | |a (OCoLC)1475648322 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Chen, Chih-Wei |d 1984- |e VerfasserIn |0 (DE-588)1151353582 |0 (DE-627)1011592835 |0 (DE-576)497695774 |4 aut | |
| 245 | 1 | 0 | |a NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia |c Chih-Wei Chen, Chi Su, Chang-Yu Huang, Xuan-Rong Huang, Xiaojing Cuili, Tung Chao, Chun-Hsiang Fan, Cheng-Wei Ting, Yi-Wei Tsai, Kai-Chien Yang, Ti-Yen Yeh, Sung-Tsang Hsieh, Yi-Ju Chen, Yuxi Feng, Tony Hunter & Zee-Fen Chang |
| 246 | 3 | 3 | |a NMEthree is a gatekeeper for DRPone-dependent mitophagy in hypoxia |
| 264 | 1 | |c 13 March 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 20 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.11.2024 | ||
| 520 | |a NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced mitophagy dependent on its active site phosphohistidine but not the NDPK function. Mice carrying a knock-in mutation in the Nme3 gene disrupting NME3 active site histidine phosphorylation are vulnerable to ischemia/reperfusion-induced infarction and develop abnormalities in cerebellar function. Our mechanistic analysis reveals that hypoxia-induced phosphatidic acid (PA) on mitochondria is essential for mitophagy and the interaction of DRP1 with NME3. The PA binding function of MOM-localized NME3 is required for hypoxia-induced mitophagy. Further investigation demonstrates that the interaction with active NME3 prevents DRP1 susceptibility to MUL1-mediated ubiquitination, thereby allowing a sufficient amount of active DRP1 to mediate mitophagy. Furthermore, MUL1 overexpression suppresses hypoxia-induced mitophagy, which is reversed by co-expression of ubiquitin-resistant DRP1 mutant or histidine phosphorylatable NME3. Thus, the site-specific interaction with active NME3 provides DRP1 a microenvironment for stabilization to proceed the segregation process in mitophagy. | ||
| 650 | 4 | |a Mechanisms of disease | |
| 650 | 4 | |a Mitophagy | |
| 650 | 4 | |a Phosphorylation | |
| 700 | 1 | |a Su, Chi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Huang, Chang-Yu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Huang, Xuan-Rong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cuili, Xiaojing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chao, Tung |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fan, Chun-Hsiang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ting, Cheng-Wei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tsai, Yi-Wei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yang, Kai-Chien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yeh, Ti-Yen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hsieh, Sung-Tsang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Yi-Ju |e VerfasserIn |4 aut | |
| 700 | 1 | |a Feng, Yuxi |d 1963- |e VerfasserIn |0 (DE-588)12237357X |0 (DE-627)705883396 |0 (DE-576)293242720 |4 aut | |
| 700 | 1 | |a Hunter, Tony |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chang, Zee-Fen |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 15(2024), Artikel-ID 2264, Seite 1-20 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia |
| 773 | 1 | 8 | |g volume:15 |g year:2024 |g elocationid:2264 |g pages:1-20 |g extent:20 |a NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-024-46385-7 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-024-46385-7 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20241127 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 12237357X |a Feng, Yuxi |m 12237357X:Feng, Yuxi |d 60000 |d 65000 |e 60000PF12237357X |e 65000PF12237357X |k 0/60000/ |k 1/60000/65000/ |p 14 | ||
| 999 | |a KXP-PPN1909611662 |e 4622959038 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1038/s41467-024-46385-7"],"eki":["1909611662"]},"recId":"1909611662","name":{"displayForm":["Chih-Wei Chen, Chi Su, Chang-Yu Huang, Xuan-Rong Huang, Xiaojing Cuili, Tung Chao, Chun-Hsiang Fan, Cheng-Wei Ting, Yi-Wei Tsai, Kai-Chien Yang, Ti-Yen Yeh, Sung-Tsang Hsieh, Yi-Ju Chen, Yuxi Feng, Tony Hunter & Zee-Fen Chang"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"family":"Chen","roleDisplay":"VerfasserIn","given":"Chih-Wei","display":"Chen, Chih-Wei","role":"aut"},{"role":"aut","family":"Su","display":"Su, Chi","roleDisplay":"VerfasserIn","given":"Chi"},{"roleDisplay":"VerfasserIn","given":"Chang-Yu","display":"Huang, Chang-Yu","family":"Huang","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Xuan-Rong","display":"Huang, Xuan-Rong","family":"Huang"},{"display":"Cuili, Xiaojing","roleDisplay":"VerfasserIn","given":"Xiaojing","family":"Cuili","role":"aut"},{"role":"aut","family":"Chao","given":"Tung","roleDisplay":"VerfasserIn","display":"Chao, Tung"},{"roleDisplay":"VerfasserIn","display":"Fan, Chun-Hsiang","given":"Chun-Hsiang","family":"Fan","role":"aut"},{"family":"Ting","roleDisplay":"VerfasserIn","given":"Cheng-Wei","display":"Ting, Cheng-Wei","role":"aut"},{"family":"Tsai","roleDisplay":"VerfasserIn","given":"Yi-Wei","display":"Tsai, Yi-Wei","role":"aut"},{"role":"aut","family":"Yang","given":"Kai-Chien","roleDisplay":"VerfasserIn","display":"Yang, Kai-Chien"},{"given":"Ti-Yen","roleDisplay":"VerfasserIn","display":"Yeh, Ti-Yen","family":"Yeh","role":"aut"},{"family":"Hsieh","roleDisplay":"VerfasserIn","display":"Hsieh, Sung-Tsang","given":"Sung-Tsang","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Yi-Ju","display":"Chen, Yi-Ju","family":"Chen"},{"family":"Feng","display":"Feng, Yuxi","roleDisplay":"VerfasserIn","given":"Yuxi","role":"aut"},{"family":"Hunter","given":"Tony","roleDisplay":"VerfasserIn","display":"Hunter, Tony","role":"aut"},{"family":"Chang","roleDisplay":"VerfasserIn","given":"Zee-Fen","display":"Chang, Zee-Fen","role":"aut"}],"titleAlt":[{"title":"NMEthree is a gatekeeper for DRPone-dependent mitophagy in hypoxia"}],"title":[{"title":"NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia","title_sort":"NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia"}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"13 March 2024"}],"relHost":[{"pubHistory":["2010-"],"origin":[{"dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK","publisherPlace":"[London] ; [London]"}],"id":{"issn":["2041-1723"],"zdb":["2553671-0"],"eki":["626457688"]},"recId":"626457688","language":["eng"],"disp":"NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxiaNature Communications","title":[{"title":"Nature Communications","title_sort":"Nature Communications"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"15","extent":"20","text":"15(2024), Artikel-ID 2264, Seite 1-20","year":"2024","pages":"1-20"},"note":["Gesehen am 13.06.24"]}],"physDesc":[{"extent":"20 S.","noteIll":"Illustrationen"}],"note":["Gesehen am 27.11.2024"],"language":["eng"]} | ||
| SRT | |a CHENCHIHWENME3ISAGAT1320 | ||