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Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity

Chronic and aberrant nucleic acid sensing causes type I IFN-driven autoimmune diseases, designated type I interferonopathies. We found a significant reduction of regulatory T cells (Tregs) in patients with type I interferonopathies caused by mutations in ADAR1 or IFIH1 (encoding MDA5). We analyzed t...

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Main Authors: Luca, Domnica (Author) , Lee, Sumin (Author) , Hirota, Keiji (Author) , Okabe, Yasutaka (Author) , Uehori, Junji (Author) , Izawa, Kazushi (Author) , Lanz, Anna-Lisa (Author) , Schütte, Verena (Author) , Sivri, Burcu (Author) , Tsukamoto, Yuta (Author) , Hauck, Fabian (Author) , Behrendt, Rayk (Author) , Roers, Axel (Author) , Fujita, Takashi (Author) , Nishikomori, Ryuta (Author) , Lee-Kirsch, Min Ae (Author) , Kato, Hiroki (Author)
Format: Article (Journal)
Language:English
Published: 1 March 2024
In: Science advances
Year: 2024, Volume: 10, Issue: 9, Pages: 1-11
ISSN:2375-2548
DOI:10.1126/sciadv.adk0820
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.adk0820
Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.adk0820
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Author Notes:Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato
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Summary:Chronic and aberrant nucleic acid sensing causes type I IFN-driven autoimmune diseases, designated type I interferonopathies. We found a significant reduction of regulatory T cells (Tregs) in patients with type I interferonopathies caused by mutations in ADAR1 or IFIH1 (encoding MDA5). We analyzed the underlying mechanisms using murine models and found that Treg-specific deletion of Adar1 caused peripheral Treg loss and scurfy-like lethal autoimmune disorders. Similarly, knock-in mice with Treg-specific expression of an MDA5 gain-of-function mutant caused apoptosis of peripheral Tregs and severe autoimmunity. Moreover, the impact of ADAR1 deficiency on Tregs is multifaceted, involving both MDA5 and PKR sensing. Together, our results highlight the dysregulation of Treg homeostasis by intrinsic aberrant RNA sensing as a potential determinant for type I interferonopathies.
Item Description:Gesehen am 27.11.2024
Physical Description:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.adk0820

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