Radiotherapy for recurrent medulloblastoma in children and adolescents: survival after re-irradiation and first-time irradiation
Background: Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects. Methods: For pre-irradiated patients, patients with re-irradiation (RT2) wer...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 May 2024
|
| In: |
Cancers
Year: 2024, Volume: 16, Issue: 11, Pages: 1-13 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16111955 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16111955 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/11/1955 
|
| Author Notes: | Jonas E. Adolph, Gudrun Fleischhack, Sebastian Tschirner, Lydia Rink, Christine Dittes, Ruth Mikasch, Philipp Dammann, Martin Mynarek, Denise Obrecht-Sturm, Stefan Rutkowski, Brigitte Bison, Monika Warmuth-Metz, Torsten Pietsch, Stefan M. Pfister, Kristian W. Pajtler, Till Milde, Rolf-Dieter Kortmann, Stefan Dietzsch, Beate Timmermann and Stephan Tippelt on behalf of the German GPOH HIT-Network |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1910093009 | ||
| 003 | DE-627 | ||
| 005 | 20250716213404.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 241202s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers16111955 |2 doi | |
| 035 | |a (DE-627)1910093009 | ||
| 035 | |a (DE-599)KXP1910093009 | ||
| 035 | |a (OCoLC)1528014367 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Adolph, Jonas E. |d 1995- |e VerfasserIn |0 (DE-588)1246458195 |0 (DE-627)1779059914 |4 aut | |
| 245 | 1 | 0 | |a Radiotherapy for recurrent medulloblastoma in children and adolescents |b survival after re-irradiation and first-time irradiation |c Jonas E. Adolph, Gudrun Fleischhack, Sebastian Tschirner, Lydia Rink, Christine Dittes, Ruth Mikasch, Philipp Dammann, Martin Mynarek, Denise Obrecht-Sturm, Stefan Rutkowski, Brigitte Bison, Monika Warmuth-Metz, Torsten Pietsch, Stefan M. Pfister, Kristian W. Pajtler, Till Milde, Rolf-Dieter Kortmann, Stefan Dietzsch, Beate Timmermann and Stephan Tippelt on behalf of the German GPOH HIT-Network |
| 264 | 1 | |c 22 May 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.12.2024 | ||
| 520 | |a Background: Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects. Methods: For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2. Results: A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7-28.7) vs. 12.0 (CI: 8.1-21.0) months] and OS [31.5 (CI: 27.6-64.8) vs. 20.0 (CI: 14.0-36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8% (CI: 1.4-45.3) vs. 0%]. RT2 improved survival most without (re)-resection [PFS: 17.5 (CI: 9.7-41.5) vs. 8.0 (CI: 6.6-12.2)/OS: 31.5 (CI: 27.6-NA) vs. 13.3 (CI: 8.1-20.1) months]. In the RT-naïve patients, CSI at recurrence improved their median PFS [25.0 (CI: 16.8-60.6) vs. 6.6 (CI: 1.5-NA) months] and OS [40.2 (CI: 18.7-NA) vs. 12.4 (CI: 4.4-NA) months]. Conclusions: RT2 could improve the median survival in a matched cohort but offered little benefit regarding long-term survival. In RT-naïve patients, CSI greatly improved their median and long-term survival. | ||
| 650 | 4 | |a medulloblastoma | |
| 650 | 4 | |a radiotherapy | |
| 650 | 4 | |a re-irradiation | |
| 650 | 4 | |a recurrence | |
| 650 | 4 | |a resection | |
| 700 | 1 | |a Fleischhack, Gudrun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tschirner, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rink, Lydia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dittes, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mikasch, Ruth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dammann, Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mynarek, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Obrecht-Sturm, Denise |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rutkowski, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Bison, Brigitte |d 1964- |e VerfasserIn |0 (DE-588)120166445 |0 (DE-627)696438410 |0 (DE-576)292074913 |4 aut | |
| 700 | 1 | |a Warmuth-Metz, Monika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pietsch, Torsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pfister, Stefan |d 1974- |e VerfasserIn |0 (DE-588)123850215 |0 (DE-627)706450930 |0 (DE-576)293908400 |4 aut | |
| 700 | 1 | |a Pajtler, Kristian Wilfried |d 1980- |e VerfasserIn |0 (DE-588)1012877264 |0 (DE-627)662768558 |0 (DE-576)346086256 |4 aut | |
| 700 | 1 | |a Milde, Till |d 1973- |e VerfasserIn |0 (DE-588)1038311837 |0 (DE-627)75711234X |0 (DE-576)39229334X |4 aut | |
| 700 | 1 | |a Kortmann, Rolf-Dieter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dietzsch, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Timmermann, Beate |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tippelt, Stephan |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 16(2024), 11, Artikel-ID 1955, Seite 1-13 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Radiotherapy for recurrent medulloblastoma in children and adolescents survival after re-irradiation and first-time irradiation |
| 773 | 1 | 8 | |g volume:16 |g year:2024 |g number:11 |g elocationid:1955 |g pages:1-13 |g extent:13 |a Radiotherapy for recurrent medulloblastoma in children and adolescents survival after re-irradiation and first-time irradiation |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers16111955 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/16/11/1955 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20241202 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1038311837 |a Milde, Till |m 1038311837:Milde, Till |d 910000 |d 910500 |d 50000 |e 910000PM1038311837 |e 910500PM1038311837 |e 50000PM1038311837 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 16 | ||
| 998 | |g 1012877264 |a Pajtler, Kristian Wilfried |m 1012877264:Pajtler, Kristian Wilfried |d 910000 |d 910500 |d 50000 |e 910000PP1012877264 |e 910500PP1012877264 |e 50000PP1012877264 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 15 | ||
| 998 | |g 123850215 |a Pfister, Stefan |m 123850215:Pfister, Stefan |d 910000 |d 910500 |e 910000PP123850215 |e 910500PP123850215 |k 0/910000/ |k 1/910000/910500/ |p 14 | ||
| 999 | |a KXP-PPN1910093009 |e 4629488812 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"origin":[{"publisher":"MDPI","dateIssuedDisp":"2009-","dateIssuedKey":"2009","publisherPlace":"Basel"}],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"disp":"Radiotherapy for recurrent medulloblastoma in children and adolescents survival after re-irradiation and first-time irradiationCancers","type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"issn":["2072-6694"],"eki":["614095670"],"zdb":["2527080-1"]},"recId":"614095670","language":["eng"],"note":["Gesehen am 27.05.2020"],"pubHistory":["1.2009 -"],"part":{"year":"2024","pages":"1-13","issue":"11","extent":"13","text":"16(2024), 11, Artikel-ID 1955, Seite 1-13","volume":"16"},"title":[{"title_sort":"Cancers","title":"Cancers"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"noteIll":"Illustrationen","extent":"13 S."}],"title":[{"title":"Radiotherapy for recurrent medulloblastoma in children and adolescents","title_sort":"Radiotherapy for recurrent medulloblastoma in children and adolescents","subtitle":"survival after re-irradiation and first-time irradiation"}],"id":{"doi":["10.3390/cancers16111955"],"eki":["1910093009"]},"recId":"1910093009","type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Jonas E. Adolph, Gudrun Fleischhack, Sebastian Tschirner, Lydia Rink, Christine Dittes, Ruth Mikasch, Philipp Dammann, Martin Mynarek, Denise Obrecht-Sturm, Stefan Rutkowski, Brigitte Bison, Monika Warmuth-Metz, Torsten Pietsch, Stefan M. Pfister, Kristian W. Pajtler, Till Milde, Rolf-Dieter Kortmann, Stefan Dietzsch, Beate Timmermann and Stephan Tippelt on behalf of the German GPOH HIT-Network"]},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"22 May 2024"}],"note":["Gesehen am 02.12.2024"],"language":["eng"],"person":[{"given":"Jonas E.","family":"Adolph","role":"aut","display":"Adolph, Jonas E."},{"family":"Fleischhack","role":"aut","display":"Fleischhack, Gudrun","given":"Gudrun"},{"given":"Sebastian","family":"Tschirner","role":"aut","display":"Tschirner, Sebastian"},{"display":"Rink, Lydia","family":"Rink","role":"aut","given":"Lydia"},{"given":"Christine","display":"Dittes, Christine","role":"aut","family":"Dittes"},{"given":"Ruth","display":"Mikasch, Ruth","family":"Mikasch","role":"aut"},{"given":"Philipp","role":"aut","family":"Dammann","display":"Dammann, Philipp"},{"given":"Martin","display":"Mynarek, Martin","family":"Mynarek","role":"aut"},{"family":"Obrecht-Sturm","role":"aut","display":"Obrecht-Sturm, Denise","given":"Denise"},{"display":"Rutkowski, Stefan","family":"Rutkowski","role":"aut","given":"Stefan"},{"given":"Brigitte","family":"Bison","role":"aut","display":"Bison, Brigitte"},{"family":"Warmuth-Metz","role":"aut","display":"Warmuth-Metz, Monika","given":"Monika"},{"given":"Torsten","family":"Pietsch","role":"aut","display":"Pietsch, Torsten"},{"family":"Pfister","role":"aut","display":"Pfister, Stefan","given":"Stefan"},{"role":"aut","family":"Pajtler","display":"Pajtler, Kristian Wilfried","given":"Kristian Wilfried"},{"display":"Milde, Till","family":"Milde","role":"aut","given":"Till"},{"display":"Kortmann, Rolf-Dieter","family":"Kortmann","role":"aut","given":"Rolf-Dieter"},{"display":"Dietzsch, Stefan","role":"aut","family":"Dietzsch","given":"Stefan"},{"family":"Timmermann","role":"aut","display":"Timmermann, Beate","given":"Beate"},{"display":"Tippelt, Stephan","role":"aut","family":"Tippelt","given":"Stephan"}]} | ||
| SRT | |a ADOLPHJONARADIOTHERA2220 | ||